High-throughput small animal PET imaging in cancer research: Evaluation of the capability of the Inveon scanner to image four mice simultaneously

Nuclear Medicine Communications

Volumn 31, Issue 10, 2010, Pages 851-858

  Aide, Nicolas ^a,b   Desmonts, Cédric ^b   Briand, Mélanie ^a   Meryet Figuiere, Mathieu ^a   Poulain, Laurent ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b CAEN UNIVERSITY HOSPITAL   (France)

Author keywords

cancer research; nude mice; small animal PET; tumour xenograft

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER DIAGNOSIS; CANCER RESEARCH; CLINICAL EVALUATION; CONTROLLED STUDY; DEVICE; DIAGNOSTIC ACCURACY; EMBRYO; EMBRYONAL CARCINOMA; EX VIVO STUDY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PHANTOM; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MICE; NEOPLASMS; PHANTOMS, IMAGING; POSITRON-EMISSION TOMOGRAPHY; QUALITY CONTROL; REFERENCE STANDARDS; TIME FACTORS;

EID: 77957326584     PISSN: 01433636     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNM.0b013e32833dc61d     Document Type: Article

References (27)

1. Nanni C, Di Leo K, Tonelli R, Pettinato C, Rubello D, Spinelli A, et al. FDG small animal PET permits early detection of malignant cells in a xenograft murine model. Eur J Nucl Med Mol Imaging 2007; 34:755-762.
2. Aide N, Poulain L, Briand M, Dutoit S, Allouche S, Labiche A, et al. Early evaluation of the effects of chemotherapy with longitudinal FDG small-animal PET in human testicular cancer xenografts: early flare response does not reflect refractory disease. Eur J Nucl Med Mol Imaging 2009; 36:396-405.
3. Cullinane C, Dorow DS, Kansara M, Conus N, Binns D, Hicks RJ, et al. An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development. Cancer Res 2005; 65:9633-9636.
4. Dorow DS, Cullinane C, Conus N, Roselt P, Binns D, McCarthy TJ, et al. Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033. Eur J Nucl Med Mol Imaging 2006; 33:441-452.
5. Nanni C, Rubello D, Fanti S. Role of small animal PET for molecular imaging in pre-clinical studies. Eur J Nucl Med Mol Imaging 2007; 34:1819-1822.
6. Nanni C, Rubello D, Khan S, Al-Nahhas A, Fanti S. Role of small animal PET in stimulating the development of new radiopharmaceuticals in oncology. Nucl Med Commun 2007; 28:427-429.
7. Bao Q, Newport D, Chen M, Stout DB, Chatziioannou AF. Performance evaluation of the inveon dedicated PET preclinical tomograph based on the NEMA NU-4 standards. J Nucl Med 2009; 50:401-408.
8. Constantinescu CC, Mukherjee J. Performance evaluation of an Inveon PET preclinical scanner. Phys Med Biol 2009; 54:2885-2899.
9. Visser EP, Disselhorst JA, Brom M, Laverman P, Gotthardt M, Oyen WJ, et al. Spatial resolution and sensitivity of the Inveon small-animal PET scanner. J Nucl Med 2009; 50:139-147.
10. Brambilla M, Secco C, Dominietto M, Matheoud R, Sachetti G, Inglese E. Performance characteristics obtained for a new 3-dimensional lutetium oxyorthosilicate-based whole-body PET/CT scanner with the National Electrical Manufacturers Association NU 2-2001 standard. J Nucl Med 2005; 46:2083-2091.
11. Daube-Witherspoon ME, Karp JS, Casey M, DiFillipo FP, Hines H, Muehllehner G, et al. PET performance measurements using the NEMA NU-2001 standard. J Nucl Med 2002; 43:1308-1409.
12. Disselhorst JA, Brom M, Laverman P, Slump CH, Boerman OC, Oyen WJ, et al. Image-quality assessment for several positron emitters using the NEMA NU 4-2008 standards in the Siemens Inveon small-animal PET scanner. J Nucl Med 2001; 51:610-617.
13. Nanni C, Pettinato C, Ambrosini V, Spinelli A, Trespidi S, Rubello D, et al. Retro-orbital injection is an effective route for radiopharmaceutical administration in mice during small-animal PET studies. Nucl Med Commun 2007; 28:547-553.
14. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 8:307-310.
15. 18F-FDG microPET studies in mouse tumor xenografts. J Nucl Med 2007; 48:602-607.
16. Cheng TE,Yoder KK, Normandin MD, Risacher SL, Converse AK, Hampel JA, et al. A rat head holder for simultaneous scanning of two rats in small animal PET scanners: design, construction, feasibility testing and kinetic validation. J Neurosci Methods 2009; 176:24-33.
17. Aide N, Desmonts C, Beauregard JM, Beyer T, Kinross K, Roselt P, et al. High throughput static and dynamic small animal imaging using clinical PET/CT: potential preclinical applications. Eur J Nucl Med Mol Imaging 2010;37:991-1001.
18. Denoyer D, Greguric I, Roselt P, Neels OC, Aide N, Taylor SR, et al. High-contrast PET of melanoma using (18)F-MEL050, a selective probe for melanin with predominantly renal clearance. J Nucl Med 2010; 51:441-447.
19. Huisman MC, Reder S, Weber AW, Ziegler SI, Schwaiger M. Performance evaluation of the Philips MOSAIC small animal PETscanner. Eur J Nucl Med Mol Imaging 2007; 34:532-540.
20. Kim JS, Lee JS, Im KC, Kim SJ, Kim SY, Lee DS, et al. Performance measurement of the microPET focus 120 scanner. J Nucl Med 2007; 48:1527-1535.
21. Wang Y, Seidel J, Tsui BM, Vaquero JJ, Pomper MG. Performance evaluation of the GE Healthcare eXplore VISTA dual-ring small-animal PET scanner. J Nucl Med 2006; 47:1891-1900.
22. Panin VY, Kehren F, Michel C, Casey M. Fully 3-D PET reconstruction with system matrix derived from point source measurements. IEEE Trans Med Imaging 2006; 25:907-921.
23. Qi J, Leahy RM, Cherry SR, Chatziioannou AF, Farquhar T. High resolution 3D Bayesian image reconstruction using the microPET small animal scanner. Phys Med Biol 1997; 43:1001-1013.
24. Boellaard R, Krak NC, Hoekstra OS, Lammertsma AA. Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study. J Nucl Med 2004; 45:1519-1527.
25. Krak NC, Boellaard R, Hoekstra OS, Twisk JW, Hoekstra CJ, Lammertsma AA. Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial. Eur J Nucl Med Mol Imaging 2005; 32:294-301.
26. Westerterp M, Pruim J, Oyen W, Hoekstra O, Paans A, Visser E, et al. Quantification of FDG PET studies using standardised uptake values in multi-centre trials: effects of image reconstruction, resolution and ROI definition parameters. Eur J Nucl Med Mol Imaging 2007; 34:392-404.
27. Visser EP, Van Dalen JA, Laverman P, Newport D, Corstens FHM, Oyen WJG, et al. Evaluation of attenuation correction in the Inveon preclinical PET scanner using two opposite, rotating 57-Co sources. Eur J Nucl Med Mol Imaging 2007; 34:S227.