GABA attenuates amyloid toxicity by downregulating its endocytosis and improves cognitive impairment

Journal of Alzheimer's Disease

Volumn 31, Issue 3, 2012, Pages 635-649

  Sun, Xiaqin ^a   Meng, Xiaolu ^c   Zhang, Jie ^d   Li, Yonghui ^c   Wang, Liping ^d   Qin, Xiaoyan ^b   Sui, Nan ^c   Zhang, Yan ^a  

^a PEKING UNIVERSITY   (China)

^b MINZU UNIVERSITY OF CHINA   (China)

^c INSTITUTE OF PSYCHOLOGY   (China)

^d SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY   (China)

Author keywords

Amyloid ; cell death; cognitive impairment; endocytosis; GABA

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; HYDROGEN PEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENDOCYTOSIS; MALE; MAZE TEST; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; WILD TYPE;

EID: 84865611937     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120535     Document Type: Article

References (34)

1. Grill JD, Cummings JL (2010) Current therapeutic targets for the treatment of Alzheimer's disease. Expert Rev Neurother 10, 711-728.
2. Rossor MN, Garrett NJ, Johnson AL, Mountjoy CQ, Roth M, Iversen LL (1982) A post-mortem study of the cholinergic and GABA systems in senile dementia. Brain 105, 313-330. (Pubitemid 12002847)
3. Mountjoy CQ, Rossor MN, Iversen LL, Roth M (1984) Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. Brain 107 (Pt 2), 507-518. (Pubitemid 14108833)
4. Lowe SL, Francis PT, Procter AW, Palmer AM, Davison AN, Bowen DM (1988) Gamma-aminobutyric acid concentration in brain tissue at two stages of Alzheimer's disease. Brain 111 (Pt 4), 785-799.
5. Ellison DW, Beal MF, Mazurek MF, Bird ED, Martin JB (1986) A postmortem study of amino acid neurotransmitters in Alzheimer's disease. Ann Neurol 20, 616-621. (Pubitemid 17181764)
6. Chu DC, Penney JB Jr, Young AB (1987) Cortical GABAB and GABAA receptors in Alzheimer's disease: A quantitative autoradiographic study. Neurology 37, 1454-1459. (Pubitemid 17132324)
7. Froestl W, Gallagher M, Jenkins H, Madrid A, Melcher T, Teichman S, Mondadori CG, PearlmanR (2004) SGS742: The first GABA (B) receptor antagonist in clinical trials. Biochem Pharmacol 68, 1479-1487. (Pubitemid 39286451)
8. Sabbagh MN (2009) Drug development for Alzheimer's disease: Where are we now and where are we headed? Am J Geriatr Pharmacother 7, 167-185.
9. Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, Collinson N, Dawson GR, Castro JL, MacLeod AM (2004) Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers. J Med Chem 47, 2176-2179. (Pubitemid 38478841)
10. Aisen PS, Saumier D, Briand R, Laurin J, Gervais F, Tremblay P, Garceau D (2006) A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 67, 1757-1763. (Pubitemid 44900749)
11. Gajcy K, Lochynski S, Librowski T (2010) A role of GABA analogues in the treatment of neurological diseases. Curr Med Chem 17, 2338-2347.
12. Lue LF, Walker DG, Brachova L, Beach TG, Rogers J, Schmidt AM, Stern DM, Yan SD (2001) Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: Identification of a cellular activation mechanism. Exp Neurol 171, 29-45. (Pubitemid 32848443)
13. Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, SchmidtAM (1996)RAGEand amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 382, 685-691. (Pubitemid 26282167)
14. Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS (2004) RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J 23, 4096-4105. (Pubitemid 39472430)
15. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B (2003) RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 9, 907-913. (Pubitemid 36889934)
16. Yoshiike Y, Kimura T, Yamashita S, Furudate H, Mizoroki T, Murayama M, Takashima A (2008) GABA (A) receptormediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin. PLoS One 3, e3029.
17. Zhang Y, Goodyer C, LeBlanc A (2000) Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3,-6,-7, and-8. J Neurosci 20, 8384-8389.
18. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100. (Pubitemid 11012976)
19. Aravanis AM, Wang LP, Zhang F, Meltzer LA, Mogri MZ, Schneider MB, Deisseroth K (2007) An optical neural interface: In vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng 4, S143-S156.
20. Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth K (2007) Circuit-breakers: Optical technologies for probing neural signals and systems. Nat Rev Neurosci 8, 577-581. (Pubitemid 47096597)
21. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55-63. (Pubitemid 14203433)
22. Zhang F, Wang LP, Boyden ES, Deisseroth K (2006) Channelrhodopsin-2 and optical control of excitable cells. Nat Methods 3, 785-792. (Pubitemid 44445824)
23. Bro S, Flyvbjerg A, Binder CJ, Bang CA, Denner L, Olgaard K, Nielsen LB (2008) A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice. Atherosclerosis 201, 274-280.
24. Han SH, Kim YH, Mook-Jung I (2011)RAGE: The beneficial and deleterious effects by diverse mechanisms of actions. Mol Cells 31, 91-97.
25. Pistis M, Belelli D, Peters JA, Lambert JJ (1997) The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: A comparative study. Br J Pharmacol 122, 1707-1719. (Pubitemid 28000208)
26. Galichet A, Weibel M, Heizmann CW (2008) Calciumregulated intramembrane proteolysis of the RAGE receptor. Biochem Biophys Res Commun 370, 1-5.
27. Zhang Y, McLaughlin R, Goodyer C, LeBlancA (2002) Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156, 519-529. (Pubitemid 34839899)
28. Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, Van Groen T, Tanila H, Koistinaho J (2007) Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. J Neurosci 27, 3712-3721. (Pubitemid 46557689)
29. Hooijmans CR, Van der Zee CE, Dederen PJ, Brouwer KM, Reijmer YD, van Groen T, Broersen LM, Lutjohann D, Heerschap A, Kiliaan AJ (2009) DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol Dis 33, 482-498.
30. Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, Cao C, Arendash GW (2009) Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience 163, 55-72.
31. Chung E, Ji Y, Sun Y, Kascsak RJ, Kascsak RB, Mehta PD, Strittmatter SM, Wisniewski T (2010) Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci 11, 130.
32. Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, Linton MF, Fazio S, LaDu MJ, Li L (2010) Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. J Biol Chem 285, 36958-36968.
33. Donkin JJ, Stukas S, Hirsch-Reinshagen V, Namjoshi D, Wilkinson A, May S, Chan J, Fan J, Collins J, Wellington CL (2010) ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J Biol Chem 285, 34144-34154.
34. Kilb W (2011) Development of the GABAergic system from birth to adolescence. Neuroscientist, doi: 10.1177-1073858411422114.