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Volumn 102, Issue , 2012, Pages 28-37

The unfolded protein response is activated in connexin 50 mutant mouse lenses

Author keywords

BiP; Cataract; Connexin 50; UPR

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CONNEXIN 50; GAP JUNCTION PROTEIN; GLUCOSE REGULATED PROTEIN 78; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

EID: 84865597117     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2012.06.004     Document Type: Article
Times cited : (26)

References (53)
  • 3
    • 68949209955 scopus 로고    scopus 로고
    • The unfolded protein response in health and disease
    • Austin R.C. The unfolded protein response in health and disease. Antioxid. Redox Signal. 2009, 11:2279-2287.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 2279-2287
    • Austin, R.C.1
  • 4
    • 0029127167 scopus 로고
    • The fate of the Golgi apparatus and the endoplasmic reticulum during lens fiber cell differentiation
    • Bassnett S. The fate of the Golgi apparatus and the endoplasmic reticulum during lens fiber cell differentiation. Invest. Ophthalmol. Vis. Sci. 1995, 36:1793-1803.
    • (1995) Invest. Ophthalmol. Vis. Sci. , vol.36 , pp. 1793-1803
    • Bassnett, S.1
  • 5
    • 73449099306 scopus 로고    scopus 로고
    • The membrane proteome of the mouse lens fiber cell
    • Bassnett S., Wilmarth P.A., David L.L. The membrane proteome of the mouse lens fiber cell. Mol. Vis. 2009, 15:2448-2463.
    • (2009) Mol. Vis. , vol.15 , pp. 2448-2463
    • Bassnett, S.1    Wilmarth, P.A.2    David, L.L.3
  • 6
    • 39149129078 scopus 로고    scopus 로고
    • Maintaining transparency: a review of the developmental physiology and pathophysiology of two avascular tissues
    • Beebe D.C. Maintaining transparency: a review of the developmental physiology and pathophysiology of two avascular tissues. Semin. Cell Dev. Biol. 2008, 19:125-133.
    • (2008) Semin. Cell Dev. Biol. , vol.19 , pp. 125-133
    • Beebe, D.C.1
  • 9
    • 0036501610 scopus 로고    scopus 로고
    • A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice
    • Chang B., Wang X., Hawes N.L., Ojakian R., Davisson M.T., Lo W.K., Gong X. A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice. Hum. Mol. Genet. 2002, 11:507-513.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 507-513
    • Chang, B.1    Wang, X.2    Hawes, N.L.3    Ojakian, R.4    Davisson, M.T.5    Lo, W.K.6    Gong, X.7
  • 10
    • 62249111354 scopus 로고    scopus 로고
    • The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium
    • DeRosa A.M., Mese G., Li L., Sellitto C., Brink P.R., Gong X., White T.W. The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium. Exp. Cell Res. 2009, 315:1063-1075.
    • (2009) Exp. Cell Res. , vol.315 , pp. 1063-1075
    • DeRosa, A.M.1    Mese, G.2    Li, L.3    Sellitto, C.4    Brink, P.R.5    Gong, X.6    White, T.W.7
  • 11
    • 38349054558 scopus 로고    scopus 로고
    • The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins
    • DeRosa A.M., Xia C.H., Gong X., White T.W. The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins. J. Cell Sci. 2007, 120:4107-4116.
    • (2007) J. Cell Sci. , vol.120 , pp. 4107-4116
    • DeRosa, A.M.1    Xia, C.H.2    Gong, X.3    White, T.W.4
  • 12
    • 79959973892 scopus 로고    scopus 로고
    • The cell biology of the unfolded protein response
    • 41 e31-32
    • Diehl J.A., Fuchs S.Y., Koumenis C. The cell biology of the unfolded protein response. Gastroenterology 2011, 141:38-41. 41 e31-32.
    • (2011) Gastroenterology , vol.141 , pp. 38-41
    • Diehl, J.A.1    Fuchs, S.Y.2    Koumenis, C.3
  • 13
    • 61849183644 scopus 로고    scopus 로고
    • Regulation of lens volume: implications for lens transparency
    • Donaldson P.J., Chee K.S., Lim J.C., Webb K.F. Regulation of lens volume: implications for lens transparency. Exp. Eye Res. 2009, 88:144-150.
    • (2009) Exp. Eye Res. , vol.88 , pp. 144-150
    • Donaldson, P.J.1    Chee, K.S.2    Lim, J.C.3    Webb, K.F.4
  • 14
    • 0035991948 scopus 로고    scopus 로고
    • Gap junctions: structure and function (Review)
    • Evans W.H., Martin P.E. Gap junctions: structure and function (Review). Mol. Membr. Biol. 2002, 19:121-136.
    • (2002) Mol. Membr. Biol. , vol.19 , pp. 121-136
    • Evans, W.H.1    Martin, P.E.2
  • 15
    • 72149134488 scopus 로고    scopus 로고
    • Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract
    • Firtina Z., Danysh B.P., Bai X., Gould D.B., Kobayashi T., Duncan M.K. Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. J. Biol. Chem. 2009, 284:35872-35884.
    • (2009) J. Biol. Chem. , vol.284 , pp. 35872-35884
    • Firtina, Z.1    Danysh, B.P.2    Bai, X.3    Gould, D.B.4    Kobayashi, T.5    Duncan, M.K.6
  • 16
    • 79951671303 scopus 로고    scopus 로고
    • Unfolded Protein Response (UPR) is activated during normal lens development
    • Firtina Z., Duncan M.K. Unfolded Protein Response (UPR) is activated during normal lens development. Gene Expr. Patterns 2011, 11:135-143.
    • (2011) Gene Expr. Patterns , vol.11 , pp. 135-143
    • Firtina, Z.1    Duncan, M.K.2
  • 18
    • 77954418511 scopus 로고    scopus 로고
    • A novel mutation in the connexin 50 gene (GJA8) associated with autosomal dominant congenital nuclear cataract in a Chinese family
    • Gao X., Cheng J., Lu C., Li X., Li F., Liu C., Zhang M., Zhu S., Ma X. A novel mutation in the connexin 50 gene (GJA8) associated with autosomal dominant congenital nuclear cataract in a Chinese family. Curr. Eye Res. 2010, 35:597-604.
    • (2010) Curr. Eye Res. , vol.35 , pp. 597-604
    • Gao, X.1    Cheng, J.2    Lu, C.3    Li, X.4    Li, F.5    Liu, C.6    Zhang, M.7    Zhu, S.8    Ma, X.9
  • 20
    • 0030725582 scopus 로고    scopus 로고
    • The crystallins: genes, proteins and diseases
    • Graw J. The crystallins: genes, proteins and diseases. Biol. Chem. 1997, 378:1331-1348.
    • (1997) Biol. Chem. , vol.378 , pp. 1331-1348
    • Graw, J.1
  • 21
    • 0037351438 scopus 로고    scopus 로고
    • Developmental genetics in ophthalmology
    • Graw J., Loster J. Developmental genetics in ophthalmology. Ophthalmic Genet. 2003, 24:1-33.
    • (2003) Ophthalmic Genet. , vol.24 , pp. 1-33
    • Graw, J.1    Loster, J.2
  • 22
    • 39149086399 scopus 로고    scopus 로고
    • Congenital cataracts and their molecular genetics
    • Hejtmancik J.F. Congenital cataracts and their molecular genetics. Semin. Cell Dev. Biol. 2008, 19:134-149.
    • (2008) Semin. Cell Dev. Biol. , vol.19 , pp. 134-149
    • Hejtmancik, J.F.1
  • 23
    • 70350498837 scopus 로고    scopus 로고
    • Cataract blindness in the developing world: is there a solution?
    • Isaacs R., Ram J., Apple D. Cataract blindness in the developing world: is there a solution?. J. Agromedicine 2004, 9:207-220.
    • (2004) J. Agromedicine , vol.9 , pp. 207-220
    • Isaacs, R.1    Ram, J.2    Apple, D.3
  • 24
  • 25
    • 0024540254 scopus 로고
    • Structural and molecular biology of the eye lens membranes
    • Kistler J., Bullivant S. Structural and molecular biology of the eye lens membranes. Crit. Rev. Biochem. Mol. Biol. 1989, 24:151-181.
    • (1989) Crit. Rev. Biochem. Mol. Biol. , vol.24 , pp. 151-181
    • Kistler, J.1    Bullivant, S.2
  • 26
    • 0029558579 scopus 로고
    • The ultrastructure of epithelial and fiber cells in the crystalline lens
    • Kuszak J.R. The ultrastructure of epithelial and fiber cells in the crystalline lens. Int. Rev. Cytol. 1995, 163:305-350.
    • (1995) Int. Rev. Cytol. , vol.163 , pp. 305-350
    • Kuszak, J.R.1
  • 27
    • 34447527676 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: signaling the unfolded protein response
    • Lai E., Teodoro T., Volchuk A. Endoplasmic reticulum stress: signaling the unfolded protein response. Physiology (Bethesda) 2007, 22:193-201.
    • (2007) Physiology (Bethesda) , vol.22 , pp. 193-201
    • Lai, E.1    Teodoro, T.2    Volchuk, A.3
  • 28
    • 0037083755 scopus 로고    scopus 로고
    • IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
    • Lee K., Tirasophon W., Shen X., Michalak M., Prywes R., Okada T., Yoshida H., Mori K., Kaufman R.J. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002, 16:452-466.
    • (2002) Genes Dev. , vol.16 , pp. 452-466
    • Lee, K.1    Tirasophon, W.2    Shen, X.3    Michalak, M.4    Prywes, R.5    Okada, T.6    Yoshida, H.7    Mori, K.8    Kaufman, R.J.9
  • 29
    • 70349923427 scopus 로고    scopus 로고
    • Perceptual learning as a potential treatment for amblyopia: a mini-review
    • Levi D.M., Li R.W. Perceptual learning as a potential treatment for amblyopia: a mini-review. Vis. Res. 2009, 49:2535-2549.
    • (2009) Vis. Res. , vol.49 , pp. 2535-2549
    • Levi, D.M.1    Li, R.W.2
  • 30
    • 74949108062 scopus 로고    scopus 로고
    • Lens gap junctions in growth, differentiation, and homeostasis
    • Mathias R.T., White T.W., Gong X. Lens gap junctions in growth, differentiation, and homeostasis. Physiol. Rev. 2010, 90:179-206.
    • (2010) Physiol. Rev. , vol.90 , pp. 179-206
    • Mathias, R.T.1    White, T.W.2    Gong, X.3
  • 32
    • 1842482987 scopus 로고    scopus 로고
    • Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
    • Poschl E., Schlotzer-Schrehardt U., Brachvogel B., Saito K., Ninomiya Y., Mayer U. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development 2004, 131:1619-1628.
    • (2004) Development , vol.131 , pp. 1619-1628
    • Poschl, E.1    Schlotzer-Schrehardt, U.2    Brachvogel, B.3    Saito, K.4    Ninomiya, Y.5    Mayer, U.6
  • 33
    • 0242380316 scopus 로고    scopus 로고
    • Severe visual impairment and blindness in children in the UK
    • Rahi J.S., Cable N. Severe visual impairment and blindness in children in the UK. Lancet 2003, 362:1359-1365.
    • (2003) Lancet , vol.362 , pp. 1359-1365
    • Rahi, J.S.1    Cable, N.2
  • 34
    • 0033949940 scopus 로고    scopus 로고
    • Congenital and infantile cataract in the United Kingdom: underlying or associated factors. British Congenital Cataract Interest Group
    • Rahi J.S., Dezateux C. Congenital and infantile cataract in the United Kingdom: underlying or associated factors. British Congenital Cataract Interest Group. Invest. Ophthalmol. Vis. Sci. 2000, 41:2108-2114.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 2108-2114
    • Rahi, J.S.1    Dezateux, C.2
  • 35
    • 68149136657 scopus 로고    scopus 로고
    • Cellular responses to endoplasmic reticulum stress and apoptosis
    • Rasheva V.I., Domingos P.M. Cellular responses to endoplasmic reticulum stress and apoptosis. Apoptosis 2009, 14:996-1007.
    • (2009) Apoptosis , vol.14 , pp. 996-1007
    • Rasheva, V.I.1    Domingos, P.M.2
  • 36
    • 0035400353 scopus 로고    scopus 로고
    • An immunohistochemical method for the detection of proteins in the vertebrate lens
    • Reed N.A., Oh D.J., Czymmek K.J., Duncan M.K. An immunohistochemical method for the detection of proteins in the vertebrate lens. J. Immunol. Methods 2001, 253:243-252.
    • (2001) J. Immunol. Methods , vol.253 , pp. 243-252
    • Reed, N.A.1    Oh, D.J.2    Czymmek, K.J.3    Duncan, M.K.4
  • 37
    • 79956055937 scopus 로고    scopus 로고
    • Activation of unfolded protein response in transgenic mouse lenses
    • Reneker L.W., Chen H., Overbeek P.A. Activation of unfolded protein response in transgenic mouse lenses. Invest. Ophthalmol. Vis. Sci. 2011, 52:2100-2108.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 2100-2108
    • Reneker, L.W.1    Chen, H.2    Overbeek, P.A.3
  • 38
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8:519-529.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 39
    • 0036023359 scopus 로고    scopus 로고
    • Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation
    • Rong P., Wang X., Niesman I., Wu Y., Benedetti L.E., Dunia I., Levy E., Gong X. Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development 2002, 129:167-174.
    • (2002) Development , vol.129 , pp. 167-174
    • Rong, P.1    Wang, X.2    Niesman, I.3    Wu, Y.4    Benedetti, L.E.5    Dunia, I.6    Levy, E.7    Gong, X.8
  • 40
    • 28844469323 scopus 로고    scopus 로고
    • Cataracts: role of the unfolded protein response
    • Shinohara T., Ikesugi K., Mulhern M.L. Cataracts: role of the unfolded protein response. Med. Hypotheses 2006, 66:365-370.
    • (2006) Med. Hypotheses , vol.66 , pp. 365-370
    • Shinohara, T.1    Ikesugi, K.2    Mulhern, M.L.3
  • 41
    • 33748789479 scopus 로고    scopus 로고
    • Mediators of endoplasmic reticulum stress-induced apoptosis
    • Szegezdi E., Logue S.E., Gorman A.M., Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 2006, 7:880-885.
    • (2006) EMBO Rep. , vol.7 , pp. 880-885
    • Szegezdi, E.1    Logue, S.E.2    Gorman, A.M.3    Samali, A.4
  • 42
    • 79955557177 scopus 로고    scopus 로고
    • Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50
    • Tong J.J., Minogue P.J., Guo W., Chen T.L., Beyer E.C., Berthoud V.M., Ebihara L. Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. Am. J. Physiol. Cell Physiol. 2011, 300:C1055-C1064.
    • (2011) Am. J. Physiol. Cell Physiol. , vol.300
    • Tong, J.J.1    Minogue, P.J.2    Guo, W.3    Chen, T.L.4    Beyer, E.C.5    Berthoud, V.M.6    Ebihara, L.7
  • 44
    • 31344438651 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the making of a professional secretory cell
    • van Anken E., Braakman I. Endoplasmic reticulum stress and the making of a professional secretory cell. Crit. Rev. Biochem. Mol. Biol. 2005, 40:269-283.
    • (2005) Crit. Rev. Biochem. Mol. Biol. , vol.40 , pp. 269-283
    • van Anken, E.1    Braakman, I.2
  • 45
    • 33750410962 scopus 로고    scopus 로고
    • A novel mutation in GJA8 associated with autosomal dominant congenital cataract in a family of Indian origin
    • Vanita V., Hennies H.C., Singh D., Nurnberg P., Sperling K., Singh J.R. A novel mutation in GJA8 associated with autosomal dominant congenital cataract in a family of Indian origin. Mol. Vis. 2006, 12:1217-1222.
    • (2006) Mol. Vis. , vol.12 , pp. 1217-1222
    • Vanita, V.1    Hennies, H.C.2    Singh, D.3    Nurnberg, P.4    Sperling, K.5    Singh, J.R.6
  • 46
    • 39549088084 scopus 로고    scopus 로고
    • A novel mutation in GJA8 associated with jellyfish-like cataract in a family of Indian origin
    • Vanita V., Singh J.R., Singh D., Varon R., Sperling K. A novel mutation in GJA8 associated with jellyfish-like cataract in a family of Indian origin. Mol. Vis. 2008, 14:323-326.
    • (2008) Mol. Vis. , vol.14 , pp. 323-326
    • Vanita, V.1    Singh, J.R.2    Singh, D.3    Varon, R.4    Sperling, K.5
  • 47
    • 77649246610 scopus 로고    scopus 로고
    • A novel GJA8 mutation (p.I31T) causing autosomal dominant congenital cataract in a Chinese family
    • Wang K., Wang B., Wang J., Zhou S., Yun B., Suo P., Cheng J., Ma X., Zhu S. A novel GJA8 mutation (p.I31T) causing autosomal dominant congenital cataract in a Chinese family. Mol. Vis. 2009, 15:2813-2820.
    • (2009) Mol. Vis. , vol.15 , pp. 2813-2820
    • Wang, K.1    Wang, B.2    Wang, J.3    Zhou, S.4    Yun, B.5    Suo, P.6    Cheng, J.7    Ma, X.8    Zhu, S.9
  • 48
    • 77957802295 scopus 로고    scopus 로고
    • Activation of the unfolded protein response by a cataract-associated alphaA-crystallin mutation
    • Watson G.W., Andley U.P. Activation of the unfolded protein response by a cataract-associated alphaA-crystallin mutation. Biochem. Biophys. Res. Commun. 2010, 401:192-196.
    • (2010) Biochem. Biophys. Res. Commun. , vol.401 , pp. 192-196
    • Watson, G.W.1    Andley, U.P.2
  • 49
    • 0032476578 scopus 로고    scopus 로고
    • Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts
    • White T.W., Goodenough D.A., Paul D.L. Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J. Cell Biol. 1998, 143:815-825.
    • (1998) J. Cell Biol. , vol.143 , pp. 815-825
    • White, T.W.1    Goodenough, D.A.2    Paul, D.L.3
  • 50
    • 33745170655 scopus 로고    scopus 로고
    • Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells
    • Xia C.H., Cheng C., Huang Q., Cheung D., Li L., Dunia I., Benedetti L.E., Horwitz J., Gong X. Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells. Exp. Eye Res. 2006, 83:688-696.
    • (2006) Exp. Eye Res. , vol.83 , pp. 688-696
    • Xia, C.H.1    Cheng, C.2    Huang, Q.3    Cheung, D.4    Li, L.5    Dunia, I.6    Benedetti, L.E.7    Horwitz, J.8    Gong, X.9
  • 51
    • 33745208795 scopus 로고    scopus 로고
    • Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation
    • Xia C.H., Cheung D., DeRosa A.M., Chang B., Lo W.K., White T.W., Gong X. Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation. J. Cell Sci. 2006, 119:2138-2144.
    • (2006) J. Cell Sci. , vol.119 , pp. 2138-2144
    • Xia, C.H.1    Cheung, D.2    DeRosa, A.M.3    Chang, B.4    Lo, W.K.5    White, T.W.6    Gong, X.7
  • 52
    • 33745114667 scopus 로고    scopus 로고
    • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis
    • Xia C.H., Liu H., Cheung D., Cheng C., Wang E., Du X., Beutler B., Lo W.K., Gong X. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development 2006, 133:2033-2040.
    • (2006) Development , vol.133 , pp. 2033-2040
    • Xia, C.H.1    Liu, H.2    Cheung, D.3    Cheng, C.4    Wang, E.5    Du, X.6    Beutler, B.7    Lo, W.K.8    Gong, X.9
  • 53
    • 40649092855 scopus 로고    scopus 로고
    • A novel connexin 50 (GJA8) mutation in a Chinese family with a dominant congenital pulverulent nuclear cataract
    • Yan M., Xiong C., Ye S.Q., Chen Y., Ke M., Zheng F., Zhou X. A novel connexin 50 (GJA8) mutation in a Chinese family with a dominant congenital pulverulent nuclear cataract. Mol. Vis. 2008, 14:418-424.
    • (2008) Mol. Vis. , vol.14 , pp. 418-424
    • Yan, M.1    Xiong, C.2    Ye, S.Q.3    Chen, Y.4    Ke, M.5    Zheng, F.6    Zhou, X.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.