Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl2 and hypoxia on gene expression of CYP3As in human fetal liver cells

Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 4, 2012, Pages 398-404

  Suzuki, Eiji ^a,b   Matsunaga, Tamihide ^c   Aonuma, Akiko ^a,d   Sasaki, Takamitsu ^e   Nagata, Kiyoshi ^e   Ohmori, Shigeru ^a,d  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Nagano Municipal Hospital   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d SHINSHU UNIVERSITY HOSPITAL   (Japan)

^e TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cobalt chloride; CYP3A4; CYP3A7; HIF 1a; Human fetal liver cell; Hypoxia

Indexed keywords

COBALT CHLORIDE; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN;

ARTICLE; CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYP3A4 GENE; CYP3A7 GENE; DOWN REGULATION; FETUS; FETUS CELL; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE LOCATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; LIVER CELL; MOLECULAR STABILITY; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; UPREGULATION;

EID: 84865349597     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-074     Document Type: Article

References (28)

1. Guengerich, F. P., Hosea, N. A., Parikh, A., Bell-Parikh, L. C., Johnson, W. W., Gillam, E. M. and Shimada, T.: Twenty years of biochemistry P450s: purification, expression, mechanism, and relevance to drugs. Drug Metab. Dispos., 26: 1175-1178 (1998).
2. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C. and Nebert, D. W.: P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6: 1-42 (1996).
3. Shimada, T., Yamazaki, H., Mimura, M., Inui, Y. and Guengerich, F. P.: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther., 270: 414-423 (1994).
4. Wienkers, L. C. and Heath, T. G.: Predicting in vivo drug interactions from in vitro drug discovery data. Nat. Rev. Drug Discov., 4: 825-833 (2005).
5. Lacroix, D., Sonnier, M., Moncion, A., Cheron, G. and Cresteil, T.: Expression of CYP3A in the human liver-evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. Eur. J. Biochem., 247: 625-634 (1997).
6. Stevens, J. C., Hines, R. N., Gu, C., Koukouritaki, S. B., Manro, J. R., Tandler, P. J. and Zaya, M. J.: Developmental expression of the major human hepatic CYP3A enzymes. J. Pharmacol. Exp. Ther., 307: 573-582 (2003).
7. Semenza, G. L.: HIF-1: mediator of physiological and pathological responses to hypoxia. J. Appl. Physiol., 88: 1474-1480 (2000).
8. Hur, E., Chang, K. Y., Lee, S. K. and Park, H.: Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxiainducible factor-1alpha. Mol. Pharmacol., 59: 1216-1224 (2001).
9. Brahimi-Horn, C., Mazure, N. and Pouyssegur, J.: Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell. Signal., 17: 1-9 (2005).
10. Demidenko, Z. N., Rapisarda, A., Garayoa, M., Giannakakou, P., Melillo, G. and Blagosklonny, M. V.: Accumulation of hypoxiainducible factor-1alpha is limited by transcription-dependent depletion. Oncogene, 24: 4829-4838 (2005).
11. Ke, Q. and Costa, M.: Hypoxia-inducible factor-1 (HIF-1). Mol. Pharmacol., 70: 1469-1480 (2006).
12. Gradin, K., Mcguire, J., Wenger, R. H., Kvietikova, I., Whitelaw, M. L., Toftgard, R., Tora, L., Gassmann, M. and Poellinger, L.: Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the arnt transcription factor. Mol. Cell. Biol., 16: 5221-5231 (1996).
13. Guillemin, K. and Krasnow, M. A.: The hypoxic response: Huffing and HIFing. Cell, 89: 9-12 (1997).
14. Wang, G. L. and Semenza, G. L.: Deferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood, 82: 3610-3615 (1993).
15. Wang, G. L. and Semenza, G. L.: Characterization of hypoxiainducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem., 268: 21513-21518 (1993).
16. Minchenko, A., Salceda, S., Bauer, T. and Caro, J.: Hypoxia regulatory elements of the human vascular endothelial growth factor gene. Cell. Mol. Biol. Res., 40: 35-39 (1994).
17. Jones, D. P.: Hypoxia and drug metabolism. Biochem. Pharmacol., 30: 1019-1023 (1981).
18. Legendre, C., Hori, T., Loyer, P., Aninat, C., Ishida, S., Glaise, D., Lucas-Clerc, C., Boudjema, K., Guguen-Guillouzo, C., Corlu, A. and Morel, F.: Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1a involvement in CYP3A4 repression. Eur. J. Cancer, 45: 2882-2892 (2009).
19. Matsunaga, T., Maruyama, M., Harada, E., Katsuyama, Y., Sugihara, N., Ise, H., Negishi, N., Ikeda, U. and Ohmori, S.: Expression and induction of CYP3As in human fetal hepatocytes. Biochem. Biophys. Res. Commun., 318: 428-434 (2004).
20. Towbin, H., Staehelin, T. and Gordon, J.: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA, 76: 4350-4354 (1979).
21. Stiehl, D. P., Jelkmann, W., Wenger, R. H. and Hellwig-Burgel, T.: Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway. FEBS Lett., 512: 157-162 (2002).
22. Thornton, R. D., Lane, P., Borghaei, R. C., Pease, E. A., Caro, J. and Mochan, E.: Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem. J., 350: 307-312 (2000).
23. Sandau, K. B., Fandrey, J. and Brüne, B.: Accumulation of HIF-1alpha under the influence of nitric oxide. Blood, 97: 1009-1015 (2001).
24. Mabjeesh, N. J., Willard, M. T., Harris, W. B., Sun, H. Y., Wang, R., Zhong, H., Umbreit, J. N. and Simons, J. W.: Dibenzoylmethane, a natural dietary compound, induces HIF-1Æ and increases expression of VEGF. Biochem. Biophys. Res. Commun., 303: 279-286 (2003).
25. 2 tension. Am. J. Physiol., 271: C1172-C1180 (1996).
26. Göpfert, T., Gess, B., Eckardt, K. U. and Kurtz, A.: Hypoxia signalling in the control of erythropoietin gene expression in rat hepatocytes. J. Cell. Physiol., 168: 354-361 (1996).
27. Semenza, G. L. and Wang, G. L.: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol., 12: 5447-5454 (1992).
28. Wang, G. L. and Semenza, G. L.: General involvement of hypoxiainducible factor 1 in transcriptional response to hypoxia. Proc. Natl. Acad. Sci. USA, 90: 4304-4308 (1993).