Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice

Journal of Alzheimer's Disease

Volumn 31, Issue 2, 2012, Pages 359-369

  Xu, Feng ^a   Vitek, Michael P ^b   Colton, Carol A ^b   Previti, Mary Lou ^a   Davis, Judianne ^a   Van Nostrand, William E ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; amyloid protein; apolipoprotein E; cerebral amyloid angiopathy; transgenic mice

Indexed keywords

APOLIPOPROTEIN E2;

AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE SEVERITY; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; VASCULAR AMYLOIDOSIS;

EID: 84865586003     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120421     Document Type: Article

References (41)

1. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
2. Steiner H, Haass C (2000) Intramembrane proteolysis by presenilins. Nat Rev Mol Biol 1, 217-224.
3. Vinters HV (1987) Cerebral amyloid angiopathy: A critical review. Stroke 18, 311-324. (Pubitemid 17059655)
4. Attems J, Jellinger K, Thal DR, Van Nostrand W (2011) Sporadic cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 37, 75-93.
5. Van Broeckhoven C, Haan J, Bakker E, Hardy JA, Van Hul W, Wehnert A, Vegter Van der Vlis M, Roos RA (1990) Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science 248, 1120-1122. (Pubitemid 20189867)
6. Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, van Duinen SG, Bots GTAM, Luyendijk W, Frangione B (1990) Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248, 1124-1126.
7. Grabowski TJ, Cho HS, Vonsattel JPG, Rebeck GW, Greenberg SM(2001) Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 49, 697-705. (Pubitemid 32530235)
8. Davis J, Van NostrandWE(1996) Enhanced pathologic properties of Dutch-type mutant amyloidβ-protein. Proc Natl Acad Sci USA 93, 2996-3000. (Pubitemid 26114352)
9. Miravalle L, Tokuda T, Chiarle R, Giaccone G, Bugiani O, Tagliavini F, Frangione B, Ghiso J (2000) Substitutions at codon 22 of Alzheimer's A-peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells. J Biol Chem 275, 27110-27116.
10. Van Nostrand WE, Melchor JP, Cho HS, Greenberg SM, RebeckGW(2001) Pathogenic effects of D23N "Iowa" amyloid-protein. J Biol Chem 276, 32860-32866.
11. Monro OR, Mackic JB,Yamada S, SegalMB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV (2002) Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging 23, 405-412. (Pubitemid 34312024)
12. Kim J, Basak JM, Holtzman DM (2009) The role of apolipoprotein E in Alzheimer's disease. Neuron 63, 287-303.
13. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, SmallGW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923. (Pubitemid 23275809)
14. Saunders AM, Schmader K, Breitner JC, Benson MD, Brown WT, Goldfarb L, Goldgaber D, Manwaring MG, Szymanski MH, McCown N, Pericak-Vance MA, Roses AD (1993) Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet 342, 710-711. (Pubitemid 23279765)
15. Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD (1993) Increased amyloid-peptide deposition in cerebral cortex as a consequence of apolipoprotein genotype in late-onset Alzheimer's disease. Proc Natl Acad Sci USA 90, 9649-9653.
16. Olichney JM, Hansen LA, Lee JH, Hofstetter CR, Katzman R, Thal LJ (1993) Relationship between severe amyloid angiopathy, apolipoprotein E genotype, and vascular lesions in Alzheimer's disease. Ann NY Acad Sci 903, 138-143.
17. Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ, Mackey B, Olney J, McKeel D, Wozniak D, Paul SM (2000) Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad SciUS A 97, 2892-2897. (Pubitemid 30159268)
18. Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM (2002) Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis 9, 305-318. (Pubitemid 34442079)
19. Fryer JD, Simmons K, Parasdanian M, Bales KR, Paul SM, Sullivan PM, HoltzmanDM(2005) Human apolipoprotein E4 alters the amyloid-beta 40 : 42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci 25, 2803-2810. (Pubitemid 40389238)
20. Rebeck GW, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 11, 575-580. (Pubitemid 23321768)
21. Mayeux R, Stern Y, Ottman R, Tatemichi TK, Tang MX, Maestre G, Ngai C, Tycko B, Ginsberg H (1993) The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Ann Neurol 34, 752-754. (Pubitemid 23333255)
22. Dodart JC, Marr RA, Koistinaho M, Gregersen BM,Malkani S, Verma IM, Paul SM (2005) Gene delivery of human apolipoprotein E alters brain A-burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 102, 1211-1216.
23. Bales KR, Liu F, Wu S, Lin S, Koger D, DeLong C, Hansen JC, Sullivan PM, Paul SM (2009) Human APOE isoformdependent effects on brain-amyloid levels in PDAPP transgenic mice. J Neurosci 29, 6771-6779.
24. Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, ZlokovicBV,Van NostrandWE(2004) Early-onset and robust cerebral microvascular accumulation of amyloid-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid-protein precursor. J Biol Chem 279, 20296-20306.
25. Miao J, Xu F, Davis J, Otte-Holler I, Verbeek MM, Van Nostrand WE (2005) Cerebral microvascular amyloid-protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid-protein precursor. Am J Pathol 167, 505-515.
26. Fan R, Xu F, Previti ML, Davis J, Grande AM, Robinson JK,Van NostrandWE(2007) Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J Neurosci 27, 3057-3063. (Pubitemid 46474134)
27. Xu F, Grande AM, Robinson JK, Previti ML, Vasek M, Davis J, Van Nostrand WE (2007) Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid betaprotein precursor transgenic mice. Neuroscience 146, 98-107. (Pubitemid 46654629)
28. Xu F, Vitek MP, Colton CA, Previti MP, Gharkholonarehe N, Davis J, Van Nostrand WE (2008) Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. J Neurosci 28, 5312-5320.
29. Johnson-Wood K, Lee M, Motter R,HuK, Gordon G, Barbour R, Khan K, Gordon M, TanH, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L (1997) Amyloid precursor protein processing and A-42 deposition in a transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 94, 1550-1555.
30. DeMattos RB, O'dell MA, Parsadanian M, Taylor JW, Harmony JA, Bales KR, Paul SM, Aronow BJ, HoltzmanDM (2002) Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 99, 10843-10848.
31. DicksonDW,Wertkin A, Mattiace LA, Fier E, KressY, Davies P, Yen SH (1990) Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta Neuropathol 79, 486-493. (Pubitemid 20095407)
32. Deane R, Wu Z, Sagare A, Davis J, Yan SD, Hamm K, Xu F, Parisi M, LaRue B, HuHW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV (2004) LRP-amyloid-peptide (A-) interaction regulates differential brain efflux of A-isoforms. Neuron 43, 333-344.
33. Long JM, Kalehua AN, Muth NJ, Calhoun ME, Jucker M, Hengemihle JM, Ingram DK, Mouton PR (1998) Stereological estimation of total microglia number in mouse hippocampus. J Neurosci Meth 84, 101-108. (Pubitemid 28485053)
34. Davis J, Xu F, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE (2006) Deficient cerebral clearance of vasculotropic Dutch/Iowa double mutant A-in human A-PP transgenic mice. Neurobiol Aging 26, 946-954.
35. Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Sturchler-Pierrat C, Burki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, JuckerM(2004) Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nature Neurosci 7, 954-960. (Pubitemid 39129504)
36. Riddell DR, Zhou H, Atchison K,Warwick HK, Atkinson PJ, Jefferson J, Xu L, Aschmies S, Kirksey Y, Hu Y, Wagner E, Parratt A, Xu J, Li Z, Zaleska MM, Jacobsen JS, Pangalos MN, Reinhart PH (2008) Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci 28, 11445-11453.
37. Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE (2012) ApoE-directed therapeutics rapidly clear-amyloid and reverse deficits in AD mouse models. Science 335, 1503-1506.
38. van Duinen SG, Castano EM, Prelli F, BotsGTAM, Luyendijk W, Frangione B (1987) Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer's disease. Proc Natl Acad SciUS A 84, 5991-5994. (Pubitemid 17130424)
39. Wattendorff AR, Frangione B, Luyendijk W, Bots GTAM (1995) Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): Clinicopathological studies. J Neurol Neurosurg Psychiatry 59, 699-705.
40. Rozemuller AJM, Roos RAC, Bots GTAM, Kamphorst W, Eikelenboom P, Van Nostrand WE (1993) Distribution of-/A4 and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease. Am J Pathol 142, 1449-1457.
41. Bornebroek M, Haan J, van Duinen SG, Maat-Schieman MLC,Van Buchem MA, Bakker E,Van BroeckhovenC, Roos RAC (1997) Dutch hereditary cerebral amyloid angiopathy: Structural lesions and apolipoprotein E genotype. Ann Neurol 41, 695-698. (Pubitemid 27212668)