Lipid peroxidation and DNA adduct formation in lymphocytes of premenopausal women: Role of estrogen metabolites and fatty acid intake

International Journal of Cancer

Volumn 131, Issue 9, 2012, Pages 1983-1990

  Sun, Xin ^a,c   Nair, Jagadeesan ^a   Linseisen, Jakob ^a,b   Owen, Robert W ^a   Bartsch, Helmut ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

DNA adducts; estrogen; fatty acids; lipid peroxidation; LPO; metabolism; premenopausal women

Indexed keywords

2 HYDROXYESTRADIOL; 4 HYDROXYESTRADIOL; ARACHIDONIC ACID; DNA; LINOLEIC ACID; MONOUNSATURATED FATTY ACID; OLEIC ACID; OMEGA 6 FATTY ACID;

ADULT; ARTICLE; BLOOD BUFFY COAT; DNA ADDUCT; DNA DAMAGE; DNA EXTRACTION; ESTRADIOL BLOOD LEVEL; ESTROGEN ACTIVITY; ESTROGEN METABOLISM; FAT INTAKE; FATTY ACID ANALYSIS; FEMALE; HORMONE STRUCTURE; HUMAN; LIPID PEROXIDATION; LYMPHOCYTE; NORMAL HUMAN; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION;

ADULT; COHORT STUDIES; DIETARY FATS; DNA ADDUCTS; DNA DAMAGE; ESTRADIOL; ESTROGENS; FATTY ACIDS, OMEGA-6; FEMALE; HUMANS; LINOLEIC ACID; LIPID PEROXIDATION; LYMPHOCYTES; OLEIC ACID; PREMENOPAUSE;

EID: 84865570916     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27479     Document Type: Article

References (37)

1. Cerutti PA,. Oxy-radicals and cancer. Lancet 1994; 44: 862-3. (Pubitemid 24290388)
2. Hussain SP, Hoeseth LJ, Harris CC,. Radical causes of cancer. Nat Rev Cancer 2003; 32: 276-85. (Pubitemid 37328863)
3. Bartsch H, Nair J,. Oxidative stress and lipid peroxidation-derived DNA lesions in inflammation driven carcinogenesis. Cancer Detec Prev 2004; 28: 386-91.
4. Vaca CE, Wilhelm J, Harms Ringdahl M,. Interaction of lipid peroxidation products with DNA. Mutat Res 1988; 195: 137-49. (Pubitemid 18066067)
5. Eckl PM, Ortner A, Esterbauer H,. Genotoxic properties of 4-hydroxy-alkenals and analogus aldehydes. Mutat Res 1993; 290: 183-92. (Pubitemid 23355129)
6. Burcham PC,. Internal hazards: baseline DNA damage by endogenous products of normal metabolism. Mutat Res 1999; 443: 11-36. (Pubitemid 29327264)
7. Marnett LJ,. Oxyradicals and DNA damage. Carcinogenesis 2000; 21: 361-70. (Pubitemid 30137921)
8. 32P-postlabelling determination of DNA adducts of malonaldehyde in humans: total white blood cells and breast tissue. Carcinogenesis 1995; 16: 1847-51.
9. Fang JL, Vaca C, Valsta LM, Mutanen M,. Determination of DNA adducts of malondialdehyde in humans: effects of dietary fatty acid composition. Carcinogenesis 1996; 17: 1035-40. (Pubitemid 26158401)
10. Wang MY, Dhingra, K, Hittleman WN, Liehr JG, Andrade M, Li DH,. Lipid peroxidation-induced putative malondialdehyde-DNA adducts in human breast tissues. Cancer Epidemol Biomarker Prev 1996; 5: 705-10. (Pubitemid 26304645)
11. Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair LA, Marnett LJ,. Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Science 1994; 65: 1580-2. (Pubitemid 24308972)
12. Nair J, Vaca CE, Velic I, Mutanen M, Valsta LM, Bartsch H,. High dietary Iω-6 polysaturated fatty acids drastically in crease formation of etheno-DNA base adducts in white blood cells of female subjects. Cancer Epidemiol Biomark Prev 1997; 6: 597-601. (Pubitemid 27342682)
13. Bartsch H, Nair J, Owen RW,. Dietary polyunsaturated fatty acids and cancer of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 1999; 20: 2209-18. (Pubitemid 30015890)
14. Davis DL, Bradlow HL, Wolff M, Wooddruff T, Hoel DG, AntonCulver H,. Medical hypothesis: xenoestrogen as preventable causes of breast cancer. Environ Health Perspect 1993; 101: 372-7.
15. Wang MY, Liehr JG,. Induction by estrogens of lipid peroxidation and lipid peroxide-derived malonaldehyde-DNA adducts in male Syrian hamsters: role of lipid peroxidation in estrogen-induced kidney carcinogenesis. Carcinogenesis 1995; 16: 1941-5.
16. Zhu BT, Conney AH,. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 1998: 19: 1-27. (Pubitemid 28376821)
17. Yager JD, Davidson NE,. Estrogen carcinogenesis in breast cancer. N Engl J Med 2006; 354: 270-82.
18. Nair J, Fang Q, Hadjiolov D, Bartsch H,. Comparison of etheno-DNA adducts in liver, colon, and white blood cells of rats gavaged with linoleic acid, oleic acid, and coconut oil. Proc Am Assoc Cancer Res 2001; 42: 695.
19. Fang QM, Nair J, Sun X, Hadjiolov D, Bartsch H,. Etheno-DNA adduct formation in rats gavaged with linoleic acid, oleic acid and coconut oil is organ- and gender specific. Mutat Res 2007; 624: 71-9. (Pubitemid 47588298)
20. Zhao Z, Kosinska W, Khmelnitsky M, Cavalieri EL, Rogan EG, Chakravarti D, Sacks PG, Guttenplan JB,. Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol. Chem Res Toxicol 2006; 19: 475-9.
21. Zahid M, Kohli E, Saeed M, Rogan E, Cavalieri E,. The greater reactivity of estradiol-3,4-quinone vs. estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity. Chem Res Toxicol 2006; 19: 164-72. (Pubitemid 43185475)
22. Kushinsky S, Anderson H,. Creepage of estrogens vs. loss by sorption on glassware. Clin Chem 1974; 20: 1528-34.
23. Riboli E, Kaaks N,. The EPIC project: rationale and study design: European prospective investigation into cancer nutrition. Int J Epidemiol 1997; 26: 6-14.
24. Boeing H, Wahrendorf J, Becker N,. EPIC-Germany-a source for studies into diet and risk of chronic diseases. Ann Nutr Metab 1999; 43: 195-204.
25. 4-ethenodeoxycytidine in liver DNA for humans and untreated rodents detected by immunoaffinity/32P-postlabeling. Carcinogenesis 1995; 16: 613-17.
26. 4-ethenodeoxycytidine by lipid peroxidation products and nucleic acid bases. Chem Res Toxicol 1995; 8: 278-83.
27. 32P-postlabeling method for analyzing the malondialdehyde- deoxyguanosine adduct, 3-(2-deoxy-β- D -erythro-pentofuranosyl)-pyrimido[1, 2-α]purinon-10(3H)one in human tissue samples. Chem Res Toxicol 2004; 17: 268-72. (Pubitemid 38252507)
28. 2-propanodeoxyguanosine DNA adduct in animal and human tissues. Chem Res Toxicol 1998; 11: 1032-41. (Pubitemid 28447292)
29. Nelson RE, Grebe SK, O'Kane DJ, Singh RJ,. Liquid chromatography tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma. Clin Chem 2004; 50: 373-84. (Pubitemid 38156379)
30. Makite M, Wells WW,. Quantitative analyses of fecal bile acids by gas-liquid chromatography. Anal Biochem 1963; 5: 523-30.
31. Hagenlocher T, Nair J, Becker N, Korfmann A, Bartsch H,. Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers: a pilot study, Cancer Epidemiol Biomarkers Prev 2001; 10: 1187-91. (Pubitemid 33064307)
32. Dedon PC, Plastaras JP, Rouzer CA, Marnett LJ,. Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. Proc Natl Acad Sci USA 1998; 95: 1113-16.
33. Nair J, Sun X, Adzersen KH, Bartsch H,. Target organ vs. surrogate levels of oxidative stress and lipid peroxidation-induced DNA adducts in women with benign and malignant breast diseases. Am Assoc Cancer Res 2008;Abstract no. 1719.
34. Bartsch H, Nair J,. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg 2006; 391: 499-510. (Pubitemid 44337612)
35. Nair J, Gansauge F, Beger H, Dolara P, Winde G, Bartsch H,. Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis. Antioxid Redox Signal 2006; 8: 1003-10. (Pubitemid 44036517)
36. Nair U, Bartsch H, Nair J,. Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans. Free Radic Biol Med 2007; 43: 1109-20. (Pubitemid 47374441)
37. 4-etheno-5-methyl-2'-deoxycytidine in human DNA: a new modified nucleoside which may perturb genome methylation. Chem Res Toxicol, in press.