Age and gender affect DNMT3a and DNMT3b expression in human liver

Cell Biology and Toxicology

Volumn 24, Issue 3, 2008, Pages 265-272

  Xiao, Yongmei ^a,b   Word, Beverly ^a   Starlard Davenport, Atena ^a   Haefele, Aaron ^a   Lyn Cook, Beverly D ^a   Hammons, George ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Ageing; DNMT3a; DNMT3b; Gender; Human liver

Indexed keywords

DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B;

ADULT; AGED; AGING; ARTICLE; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENOTYPE; HUMAN; HUMAN TISSUE; LIVER; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; BASE SEQUENCE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA PRIMERS; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; SEX FACTORS;

EID: 42549094987     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10565-007-9035-9     Document Type: Article

References (58)

1. Abdelrahim M, Samudio I, Smith R, et al. Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. J Biol Chem 2002;277:28815-22.
2. Bachmann KE, Rountree MR, Baylin SB. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem 2001;276:32282-7.
3. Bakin AV, Curran T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science 1999;283:387-90.
4. Belinsky SA, Nikula KJ, Baylin SB, Issa J-PJ. Increased cytosine DNA- methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc Natl Acad Sci 1996;93:4045-50.
5. Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet 2000;9:2395-402.
6. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002;16:6-21.
7. Boivin AJ, Momparler, LF, Hurtubise A, Momparler RL. Antineoplastic actionof 5-aza-2′-deoxycytidine and phenylbutyrate on human lung carcinoma cells. Anticancer Drugs 2002;13:869-74.
8. Casillas MA, Lopatina N, Andrews LG, Tollefsbol TO. Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol Cell Biochem 2003;252:33-43.
9. Chuang LS, Ian HI, Koh TW, et al. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 1997;277:1996-2000.
10. Cui X, Wakai T, Shirai Y, et al. Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells. Human Pathol 2006;37:298-311.
11. Dawson-Saunders B, Trapp RG. Basic and clinical biostatistics. Norwalk, CT: Appleton and Lange; 1994.
12. Egger G, Aparicio AM, Escobar SG, Jones PA. Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment. Cancer Res 2007;67:346-53.
13. Eng C, Herman JG, Baylin SB. A bird's eye view of global methylation. Nat Genet 2000;24:101-2.
14. Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002;21:5427-40.
15. Esteve PO, Chin HG, Pradhan. Human maintenance DNA (cytosine-5)- methyltransferase and p53 modulate expression of p53-repressed promoters. Proc Natl Acad Sci 2005;102:1000-5.
16. Fiala ES, Staretz ME, Pandya GA, et al. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay of DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis 1998;19:597-604.
17. Fuks F, Burgers WA, Godin N, et al. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 2001;20:2536-3544.
18. Hammons GJ, Yan Y, Lopatina NG, et al. Increased expression of hepatic DNA methyltransferase in smokers. Cell Biol Toxicol 1999:15:389-94.
19. Jinawath A, Miyake S, Yanagisawa Y, et al. Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochem J 2005;385:557-64.
20. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
21. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science (Wash. DC) 2001;293:1068-70.
22. Jue K, Benoit G, Alcivar-Warren AA, Trasler JM. Developmental and hormonal regulation of DNA methyltransferase in the rat testis. Biol Reproduction 1995;52:1361-71.
23. Kim YI. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev 2004;13:511-9.
24. Kishikawa S, Murata T, Kimura H, et al. Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins. Eur J Biochem 2002;269:2961-70.
25. Laird PW, Jaenisch R. The role of DNA methylation in cancer genetic and epigenetics. Annu Rev Genet 1996;30:441-64.
26. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992;69:915-26.
27. Li E, Beard C, Jaenisch R. Role for DNA methylation in genomic imprinting. Nature 1993;366:362-5.
28. Liang G, Chan MF, Tomigahara Y, et al. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol 2002;22:480-91.
29. Lopatina N, Haskell JF, Andrews LG, et al. Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts. J Cell Biochem 2002;84:324-34.
30. MacLeod AR, Rouleau J, Szyf M. Regulation of DNA methylation by the Ras signaling pathway. J Biol Chem 1995;270:11327-37.
31. Nagai M, Nakamura A, Makino R, Mitamura K. Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas. Hepatol Res 2003;26:186-91.
32. Nan X, Coampoy FJ, Bird A. MeCP2 is a transcription repressor with abundant binding sites in genomic chromatin. Cell 1997;88:471-81.
33. Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 1998;19:219-20.
34. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999;99:247-57.
35. Oue N, Kuraoka K, Kuniyasu H, et al. DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas. Oncol Rep 2001;8:1085-9.
36. Pradhan S, Bacolla A, Wells RD, Roberts RJ. Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J Biol Chem 1999;274:33002-10.
37. Raiche J, Rodriguez-Juarez R, Pogribny I, Kovalchuk O. Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice. Biochem Biophys Res Commun 2004;325:39-47.
38. Reddy PMS, Reddy PRK. Regulation of DNA methyltransferase in the testis of rats. Biochem Int 1988;16:543-7.
39. Reu FJ, Leaman DW, Maitra RR, et al. Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons. Cancer Res 2006;66:2785-93.
40. Rhee I, Bachman KE, Park BH, et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 2002;416:552-6.
41. Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2003;2:245-61.
42. Robertson, KD, Uzvolgyi E, Liang G, et al. The human DNA methyltransferases (DNMTs) 1, 3a, and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 1999;27:2292-8.
43. Rouleau J, MacLeod AR, Szyf M. Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J Biol Chem 1995;270:1595-601.
44. Saito Y, Kanai Y, Nakagawa T, et al. Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer 2003;105:527-32.
45. Shen H, Wang L, Spitz MR, et al. A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res 2002;62:4994-5.
46. Slack A, Cervone N, Pinared M, Szyf M. DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. J Biol Chem 1999a;274:10105-12.
47. Slack A, Cervoni N, Pinard M, Szyf M. Feedback regulation of DNA methyltransferase gene expression by methylation. Eur J Biochem 1999b;264:191-9.
48. Stewart CL, Stuhlmann H, Jahner D, Jaenisch R. De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. Proc Natl Acad Sci 1982;79:4098-102.
49. Sun L, Hui AM, Kanai Y, et al. Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis. Jpn J Cancer Res 1997;88:1165-70.
50. Sun J-M, Spencer VA, Li L, et al. Estrogen regulation of trefoil factor 1 expression by estrogen receptor α and Sp proteins. Exper Cell Res 2005;302:96-107.
51. Szyf M. DNA methylation properties: consequences for pharmacology. Trends Pharmacol Sci 1994;15:233-8.
52. 2-terminal kinase signaling. Cancer Res 2006;66:11668-76.
53. Vertino PM, Issa J-P, Pereira-Smith OM, Baylin SB. Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortization of human fibroblasts. Cell Growth Differ 1994;5:1395-402.
54. Vertino PM, Yen RW, Gao J, Baylin SB. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)- methyltransferase. Mol Cell Biol 1996;16:4555-65.
55. Wang L, Rodriguez M, Kim ES, et al. A novel C/T polymorphism in the core promoter of human de novo cytosine DNA methyltransferase 3B6 is associated with prognosis in head and neck cancer. Int J Oncol 2004;25:993-9.
56. Wang R, Zhang Q-G, Han D, et al. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-inducted neuroprotection against transient global cerebral ischema by non-genomic mechanism in male rats. J Neurochem 2006;99:1543-54.
57. Xie S, Wang Z, Okano M, et al. Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 1999;236:87-95.
58. Xiong Y, Dowdy SC, Xue A, et al. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Gynecol Oncol 2005;96:601-9.