Antioxidant and hepatorenoprotective effects of Thyme vulgaris extract in rats during aflatoxicosis

Global Journal of Pharmacology

Volumn 6, Issue 2, 2012, Pages 106-117

  Hamzawy, Mohamed A ^a   El Denshary, Ezzeldein S M ^b   Hassan, Nabila S ^c   Manaa, Fathia ^c   Abdel Wahhab, Mosaad A ^c  

^a Misr University for Science and Technology   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Aflatoxins; Kidney; Liver; Oxidative stress; Thyme vulgaris

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CREATININE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 1BETA; MALONALDEHYDE; METHANOL; PLANT EXTRACT; SUPEROXIDE DISMUTASE; THYME VULGARIS EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA; WATER;

AFLATOXICOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME LOCALIZATION; HISTOCHEMISTRY; LIVER HISTOLOGY; LIVER INJURY; LIVER PROTECTION; LOW DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; THYME; THYME VULGARIS;

EID: 84865552689     PISSN: 19920075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Chen, C.J., Y.J. Zhang, S.N. Lu and R.M. Santella, Aflatoxin B, DNA adducts in smeared tumor tissue from patients with hepatocellular carcinoma. Hepatol., 16: 50-55.
2. Williams, J.H., T.D. Phillips, P.E. Jolly, J.K. Stiles, CM. Jolly and D. Aggarwal, 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences and interventions. Am. J. Clin. Nut, 80: 1106-1122.
3. Lunn, R.M., Y.J. Zhang, L.Y. Wang, C.J. Chen, P.H. Lee, C.S. Lee, W. Y. Tsai and R.M. Santella, 1997. pp: 53 Mutations, Chronic Hepatitis B Virus Infection and Alfatoxin Exposure in Hepatocellular Carcinoma in Taiwan. Cancer Res., 57: 3471-3477.
4. McGlynn, K.A., L. Tsao, A.W. Hsing, S.S. Devesa and Jr. J.F. Fraumeni, 2001. International trends and patterns of primary liver cancer. Int. J. Cancer, 94: 290-296.
5. El-Serag, H.B. and A.C. Mason, 1999. Rising incidence of hepatocellular carcinoma in the United States. N. Engl. J. Med., 340: 745-750.
6. El-Zayadi, A.R., H.M. Badran, E.M. Barakat, M.D. Attia, S. Shawky, M.K. Mohamed, O. Selim and A. Saeid, 2005. Hepatocellular carcinoma in Egypt: a single center study over a decade. World J. Gastroenterol, 11: 5193-5198.
7. FAO/WHO, 1999. Joint F AO/WHO Expert Committee on Food Additives (JECFA): B.G. Aflatoxins and M. WHO Technical Report, Geneva, 884: 69-77.
8. Munro, I., 1976. Naturally occurring toxicants in foods and their significance. Clin. Toxicol., 9: 647-663.
9. IARC (International Agency for Research on Cancer), Aflatoxins. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC. Lyon, France, 56: 243-395.
10. IARC (International Agency for Research on Cancer), Some traditional herbal medicines, some mycotoxms, naphthalene and styrene. In: IARC Monograph Evaluation Carcinogen Risk of Human, Lyon, France, pp: 1-556.
11. Rawal, S., J.E. Kim and R. Jr. Coulombe, 2010. Aflatoxin B, in poultry: Toxicology, metabolism and prevention. Res Vet. Sci., 89: 325-331.
12. Abdel-Wahhab, M.A., S.A. Nada, I.M. Farag, N.F. Abbas andH.A. Amra, 1998. Potential protective effect of HSCAS and bentonite against dietary aflatoxicosis in rat: with special reference to chromosomal aberrations. Nat. Toxin., 6: 211-218.
13. Abdel-Wahhab, M.A., H.H. Ahmed and M.M. Hagazi, 2006. Prevention of aflatoxin B, initiated hepatotoxicity in rat by marine algae extracts. J. Appl. Toxicol., 26: 229-238.
14. Abdel-Wahab, M., N. El-Ghawalby, M. Mostafa, A. Sultan, M. El-Sadany, O. Fathy, T. Salah and F. Ezzat, 2007. Epidemiology of hepatocellular carcinoma in lower Egypt, Mansoura Gastroenterology Center. Hepatogastroenterol., 54: 157-162.
15. Abdel-Wahhab, M.A., N.S. Hassan, A.A. El-Kady, Y.A. Khadrawy, A.A. El-Nekeety, S.R. Mohamed, H.A. Sharaf and F.A. Mannaa, 2010. Red ginseng extract protects against aflatoxin B! and fumonisins- induced hepatic pre-cancerous lesions in rats. Food Chem. Toxicol., 48: 733-742.
16. Abdel-Aziem, S.H., A.M. Hassan and M.A. Abdel- Wahhab, 2011. Dietary supplementation with whey protein and ginseng extract counteracts oxidative stress and DNA damage in rats fed an aflatoxin- contaminated diet. Muta. Res., 723: 65-71.
17. Dapkevicius, A., T.A. van Beek, G.P. Lelyveld, A. van Veldhuizen, A. de Groot, J.P.H. Linssen and R. Venskutonis, 2002. Isolation and Structure Elucidation of Radical Scavengers from Thymus vulgaris Leaves. J. Nat. Prod., 65: 892-896.
18. EMAEMHU (European Medicines Agency Evaluation of Medicines for Human Use), 2006. Committee on Herbal Medicinal Products (HMPC) In: Community herbal monograph on Thymus vulgaris L. and Thymus zygis L., herba, final document of 31 October 2007 Doc. Ref. EMEA/HMPC/ 234113.
19. Van Den Broucke, CO. and J.A. Lemli, 1983. Spasmolytic activity of the flavonoids from Thymus vulgaris. Pharm. Weekbl. Sci., 5: 9-14.
20. Marino, M., C. Bersani and G. Comi, 1999. Antimicrobial activity of the essential oils of Thymus vulgaris L. measured using a bioimpedometric method. J. FoodProt, 62: 1017-1023.
21. Miura, K., H. Kikuzaki and N. Nakatam, 2002. Antioxidant activity of chemical components from sage (Salvia officinalis L) and thyme {Thymus vulgaris L.) measured by the oil stability index method. J. Agri. Food Chem., 50: 1845-1851.
22. Pina-Vaz, C, Rodrigues A. Goncalves, E. Pinto, de Oliveira S. Costa, C. Tavares, L. Salgueiro, C. Cavaleiro, M. J. Goncalves and de Oliveira J. Martinez, Antifungal activity of Thymus oils and their major compounds. J. Eur. Acad. Dermatol. Venereol., 18:73-78.
23. Chizzola, R., H. Michitsch and C. Franz, 2008. Antioxi dative properties of Thymus vulgaris leaves: comparison of different extracts and essential oil chemotypes. J. Agri. Food Chem., 56: 6897-8904.
24. Hutchins, J.E. and W.M. Jr. Hagler, 1983. Rapid liquid chromatographic determination of aflatoxins in heavily contaminated corn. J. Assoc. Off. Anal. Chem., 66: 1458-1465.
25. Jayaprakasha, G.K. and LJ. Rao, 2000. Phenolic constituents from the lichen Parmotrema stuppeum (Nyl.) Hale and their antioxidant activity. Zeitschrift Fur Naturforschung, C 55: 1018-1022.
26. Jayaprakasha, G.K., T. Selvi andK.K. Sakariah, 2003. Antibacterial and antioxidant activities of grape (Vitis vinifera) seed extracts. Food Res. Int., 36: 117-22.
27. Nogala-Kalucka, M., J. Korczak, M. Dratwia, E. Lampart-Szczapa, A. Siger and M. Buchowski, Changes in antioxidant activity and free radical scavenging potential of rosemary extract and tocopherols in isolated rapeseed oil triacylglycerols during accelerated tests. Food Chem., 93: 227-35.
28. Drury, R.A., E.A. Wallington andR. Cancerson, 1980. Carlton's histopathological techniques. 4th ed. Oxford, London, New York: Oxford University Press.
29. SAS (SAS Institute Inc.), 1982. SAS User's Guide: Statistics. SAS Institute, Cary, NC.
30. Waller, R.A. and D.B. Duncan, 1969. ABayes rule for the symmetric multiple comparison problems. J. Am. Stat. Assoc, 64: 1484-1503.
31. Majhemc, L., M. Skerget and Z. Knez, 2007. Antioxidant and antimicrobial activity of guarana seed extracts. Food Chem., 104: 1258-1268.
32. Rababah, T.M., F. Banat, A. Rababah, K. Ereifej and W. Yang, 2010. Optimization of extraction conditions of total phenohcs, antioxidant activities and anthocyanin of oregano, thyme, terebinth and pomegranate. J. Food Sci., 75: C626-C632.
33. Lin, C.W.E.N., C.W.E.N. Yu, S.C. Wu and K.H. Yih, DPPH Free-Radical Scavenging Activity, Total Phenolic. J. Food Drug Anal, 17: 386-395.
34. Ali-Shtayeh, M.S., M.A. Al-Nuri, R.M.R. Yaghmour and Y.R. Faidi, 1997. Antimicrobial activity of Micromena nervosa from the Palestinian area. J. Ethnopharmacol., 58: 143-147.
35. Abdel-Wahhab, M.A. and S.E. Aly, 2003. Antioxidants and radical scavenging properties of vegetable extracts in rats fed aflatoxin-contaminated diet. J. Agnc. Food Chem., 51: 2409-2414.
36. Shati, A.A. and F.G. Elsaid, 2009. Effects of water extracts of thyme (Thymus vulgaris) and ginger (Zmgiber officinale Roscoe) on alcohol abuse. Food Chem. Toxicol., 47: 1945-1949.
37. Rustemeyer, S.M., W.R. Lamberson, D.R. Ledoux, G.E. Rottinghaus, D.P. Shaw, R.R. Cockrum, K.L. Kessler, KJ. Austin andK.M. Cammack, 2010. Effects of dietary aflatoxin on the health and performance of growing barrows. J. Anim. Sci., 88: 3624-3630.
38. Rastogi, R., A.K. Srivastava and A.K. Rastogi, Biochemical changes induced in liver and serum of aflatoxin Bj treated male Wistar rats: preventive effect of picroliv. Pharmacol. Toxicol., 88: 53-58.
39. Barber, M.D., D.C. McMillan, A.M. Wallace, J.A. Ross, T. Preston and K.C.H. Fearon, 2004. The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer. Br. J. Cancer, 90: 1129-1132.
40. Osborne, D.J., W.E. Huff, P.B. Hamilton and H.R. Burmeister, 1982. Comparison of ochratoxin, aflatoxin and T-2 toxin for their effects on selected parameters related to digestion and evidence for specific metabolism of carotenoids in chickens. Poult. Sci., 61: 1646-1652.
41. Lesson, S., G. Diaz and J. Summers, 1995. Poultry Metabolic Disorders and Mycotoxins. Montreal Canada, University Books, pp: 249-298.
42. Abdel-Wahhab, MA., S.A. Nada and F.A. Khahl, Physiological and toxicological responses in rats fed aflatoxin-contaminated diet with or without sorbent materials. Anim. Feed Sci. Tech., 97: 209-219.
43. El-Agamy, D.S., 2010. Comparative effects of curcumin and resveratrol on aflatoxin Brinduced liver injury in rats. Arch. Toxicol., 84: 389-396.
44. El-Nekeery, A.A., S.R. Mohamed, A.S. Hathout, N.S. Hassan, S.E. Aly and M.A. Abdel-Wahhab, Antioxidant properties of thymus vulgaris oil against aflatoxin-induce oxidative stress in male rats. Toxicon.,57: 984-991.
45. Jmdal, N., S.K. Mahipal and N.K. Mahajan, Toxicity of aflatoxin B, in broiler chicks and its reduction by activated charcoal. Res. Vet. Sci., 56: 37-40.
46. Abdel-Wahhab, M.A. and S.E. Aly, 2005. Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis. J. Appl. Toxicol., 25: 218-223.
47. Miller, D.M. and D.M. Wilson, 1994. Veterinary diseases related to aflatoxins, The toxicology of aflatoxins. San Diego, CA, Academic Press, pp: 347-364.
48. Abdel-Wahhab, M.A. and A.M. Kholif, 2008. Mycotoxins in animal feeds and prevention strategies: A review. Asian J. Anim. Sci., 2: 7-25.
49. Yang, C.F., J. Liu, S. Wasser, H.M. Shen, C.E.L. Tan and C.N. Ong, 2000. Inhibition of ebselen on aflatoxin Brinduced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis, 21: 2237-2243.
50. Sell, S., K.L. Xu, W.E. Huff,L.F. Kabena, R.B. Harvery and H.A. Dunsford, 1998. Aflatoxin exposure produces serum alphafetoprotein elevations and marked oval cell proliferation in young male Pekin ducklings. Pathol., 30: 34-39.
51. Gitto, E., S. Pellegrino, P. Gitto, I. Barberi and R.J. Reiter, 2009. Oxidative stress of the newborn in the pre and postnatal period and the clinical utility of melatonm. J. Pin. Res., 46: 128-139.
52. Moon, E. Y., D.K. Rhee and S. Pyo, 1999. Involvement of NO, H2O2 and TNF-[alpha] in the reduced antitumor activity of murine peritoneal macrophages by aflatoxin B,. Cancer Lett., 136: 167-1676.
53. Suganuma, M., E. Sueoka, N. Sueoka, S. Okabe and H. Fujiki, 2000. Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression. Biofactors, 13: 67-72.
54. Rollinson, S., A.P. Levene, F.K. Mensah, P.L. Roddam, J.M. Allan, T.C. Diss, E. Roman, A. Jack, K. MacLennan, M.F. Dixon and G. J. Morgan, Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity. Blood, 102: 1007-1011.
55. Hopkins, S.J., 2003. The pafhophysiological role of cytokines. Legal Med., 5: S45-S57.
56. Barton, C.C., E.X. Barton, P.E. Ganey, S.L. Kunkel and R.A. Roth, 2001. Bacterial lipopolysaccharide enhances aflatoxin B! hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor. Hepatol., 33: 66-73.
57. Voss, K.A., R. Riley, C. Dunn and Corton J. Christopher, 2006. The role of tumor necrosis factor and the peroxisome proliferator-activated receptor in modulating the effects of fumomsm in mouse liver. Toxicol, 222: 165-174.
58. Cao, J., L.P. Jiang, X.M. Zhang, X.F. Yao, C.Y. Geng, X.X. Xue and L.F. Zhong, 2008. Boric acid inhibits LPS-induced TNF-alpha formation through a thiol- dependent mechanism in THP-1 cells. J. Trace Elem. Med. Biol., 22: 189-195.
59. Zhou, H.P., H. Lutterodt, Z.H. Cheng and L.L. Yu, Anti-inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from sophora flavescens roots. J. Agric. FoodChem., 57: 4580-4585.
60. Hathout, A.S., S.R. Mohamed, A.A. El-Nekeety, N.S. Hassan, S.E. Aly and M.A. Abdel-Wahhab, 2011. Ability of lactobacillus casei and lactobacillus reuteri to protect against oxidative stress in rats fed aflatoxins-contaminated diet. Toxicon., 58: 179-186.
61. Loziene, K., P.R. Venskutoms, A. Sipaihene and J. Labokas, 2007. Radical scavenging and antibacterial properties of the extracts from different Thymus pulegioides L. chemotypes. Food Chem., 103: 546-559.
62. Braga, P.C., M. Dal Sasso, M. Culici, T. Bianchi, L. Bordoni and L. Marabini, 2006. Anti-inflammatory activity of thymol: inhibitory effect on the release of human neutrophil elastase. Pharmacology, 77: 130-136.
63. Uyanoglu, M., M. Canbek, E. Aral and C.B.K. Husnu, Effects of carvacrol upon the liver of rats undergoing partial hepatectomy. Phytomedicine, 15:226-229.
64. Tsai, M.L., C.C. Lin, W.C. Lin and C.H. Yang, 2011. Antimicrobial, antioxidant and anti-inflammatory activities of essential oils from five selected herbs. Biosci. Biotechnol. Biochem., 75: 1977-1983.
65. Paur, I., T.R. Balstad, M. Kolberg, M.K. Pedersen, L.M. Austenaa, D.R. Jacobs and R. Blomhoff, 2010. Extract of oregano, coffee, thyme, clove and walnuts inhibits NF- B in monocytes and in transgenic reporter mice. Cancer Prev. Res., 3: 653-663.