Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin

Carcinogenesis

Volumn 33, Issue 9, 2012, Pages 1754-1761

  Yanagida, Jodi ^a   Hammiller, Brianna ^a   Al Matouq, Jenan ^a   Behrens, Michaela ^a   Trempus, Carol S ^b   Repertinger, Susan K ^a   Hansen, Laura A ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 OXO DEOXYGUANOSINE; CELL DIVISION CYCLE 25A ENZYME; DEOXYGUANOSINE DERIVATIVE; PHOSPHATASE; UNCLASSIFIED DRUG;

ABLATION THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INCIDENCE; CARCINOGENESIS; CDC25A GENE; CELL CYCLE ARREST; CELL CYCLE CHECKPOINT; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME DEGRADATION; EPIDERMIS; GENE; GENE DELETION; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN CANCER; SKIN TUMOR; TUMOR GROWTH; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CDC25 PHOSPHATASES; CELL CYCLE; CELL PROLIFERATION; DNA; DNA DAMAGE; MICE; MICE, INBRED C57BL; SKIN; ULTRAVIOLET RAYS;

EID: 84865549978     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs168     Document Type: Article

References (34)

1. Rogers, H.W. et al. (2010) Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch. Dermatol., 146, 283-287.
2. Lo, H.L. et al. (2005) Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest. BMC Cancer, 5, 135.
3. You, Y.H. et al. (2001) Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells. J. Biol. Chem., 276, 44688-44694.
4. Halliday, G.M. (2005) Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis. Mutat. Res., 571, 107-120.
5. Marrot, L. et al. (2008) Skin DNA photodamage and its biological consequences. J. Am. Acad. Dermatol., 58, S139-S148.
6. Shigenaga, M.K. et al. (1989) Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc. Natl. Acad. Sci. U.S.A., 86, 9697-9701.
7. Ziech, D. et al. (2011) Reactive oxygen species (ROS)-induced genetic and epigenetic alterations in human carcinogenesis. Mutat. Res., 711, 167-173.
8. Boutros, R. et al. (2007) CDC25 phosphatases in cancer cells: key players? Good targets? Nat. Rev. Cancer, 7, 495-507.
9. Sancar, A. et al. (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem., 73, 39-85.
10. Zou, X. et al. (2001) The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. Mol. Cell Biol., 21, 4818-4828.
11. Wang, Z. et al. (2008) Cdc25A protein phosphatase: a therapeutic target for liver cancer therapies. Anticancer Agents Med. Chem., 8, 863-871.
12. Lee, G. et al. (2009) Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proc. Natl. Acad. Sci. U.S.A., 106, 4701-4706.
13. Vasioukhin, V. et al. (1999) The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl. Acad. Sci. U.S.A., 96, 8551-8556.
14. Hansen, L.A. et al. (1998) Effect of the viable-yellow (Avy) agouti allele on skin tumorigenesis and humoral hypercalcemia in v-Ha-ras transgenci TG. AC mice. Carcinogen, 19, 1837-1845.
15. Hansen, L.A. et al. (1990) Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion. Cancer Res., 50, 5740-5745.
16. Madson, J.G. et al. (2009) Erbb2 suppresses DNA damage-induced checkpoint activation and UV-induced mouse skin tumorigenesis. Am. J. Pathol., 174, 2357-2366.
17. Vindelov, L.L. (1977) Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei. Virchows Arch. B. Cell Pathol., 24, 227-242.
18. Wulff, B.C. et al. (2008) Topical treatment with OGG1 enzyme affects UVB-induced skin carcinogenesis. Photochem. Photobiol., 84, 317-321.
19. Leisser, C. et al. (2004) Subcellular localisation of Cdc25A determines cell fate. Cell Death Differ., 11, 80-89.
20. Trempus, C.S. et al. (1998) Photocarcinogenesis and susceptibility to UV radiation in the v-Ha-ras transgenic Tg. AC mouse. J. Invest. Dermatol., 111, 445-451.
21. Leder, A. et al. (1990) v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci. U.S.A., 87, 9178-9182.
22. van der Schroeff, J.G. et al. (1990) Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin. J. Invest. Dermatol., 94, 423-425.
23. Pierceall, W.E. et al. (1991) Ras gene mutation and amplification in human nonmelanoma skin cancers. Mol. Carcinog., 4, 196-202.
24. Ananthaswamy, H.N. et al. (1992) Molecular alterations in human skin tumors. Prog. Clin. Biol. Res., 376, 61-84.
25. Pierceall, W.E. et al. (1992) N-ras mutation in ultraviolet radiation-induced murine skin cancers. Cancer Res., 52, 3946-3951.
26. Dassule, H.R. et al. (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development, 127, 4775-4785.
27. Lloyd, C. et al. (1995) The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J. Cell Biol., 129, 1329-1344.
28. Byrne, C. et al. (1994) Programming gene expression in developing epidermis. Development, 120, 2369-2383.
29. Yu, B.D. et al. (2008) Skin and hair: models for exploring organ regeneration. Hum. Mol. Genet., 17, R54-R59.
30. Nagy, A. (2000) Cre recombinase: the universal reagent for genome tailoring. Genesis, 26, 99-109.
31. Pascucci, B. et al. (2011) Role of nucleotide excision repair proteins in oxidative DNA damage repair: an updating. Biochemistry (Mosc.), 76, 4-15.
32. Lynch, D. et al. (2007) Mouse skin models for carcinogenic hazard identification: utilities and challenges. Tox. Pathol., 35, 853-864.
33. Kar, S. et al. (2003) Antitumor and anticarcinogenic actions of Cpd 5: a new class of protein phosphatase inhibitor. Carcinogenesis, 24, 411-416.
34. Kar, S. et al. (2006) PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo. Mol. Cancer Ther., 5, 1511-1519.