Mouse skin models for carcinogenic hazard identification: Utilities and challenges

Toxicologic Pathology

Volumn 35, Issue 7, 2007, Pages 853-864

  Lynch, Dave ^a   Svoboda, Jessica ^a   Putta, Sumanth ^a   Hofland, Hans E J ^b   Chern, Wendy H ^b   Hansen, Laura A ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Stiefel Laboratories Inc   (United States)

Author keywords

Biomarkers; Carcinogen identification; Carcinogenesis; Inflammation; Irritation; Proliferation; Skin tumors

Indexed keywords

BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CARCINOGENESIS; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS HYPERPLASIA; HYPERPLASIA; HYPOTHESIS; INFLAMMATION; MEDICAL RESEARCH; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSITIVE TO CARCINOGENESIS MOUSE; SENSITIVITY ANALYSIS; SKIN INFLAMMATION; SKIN IRRITATION; SKIN TUMOR; TREATMENT DURATION;

ANIMALS; CARCINOGENS; KERATIN-6; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

MUS;

EID: 37549004839     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230701748131     Document Type: Review

References (43)

1. Albert, R. E., French, J. E., Maronpot, R., Spalding, J., and Tennant, R. (1996). Mechanism of skin tumorigenesis by contact sensitizers: the effect of the corticosteroid fluocinolone acetonide on inflammation and tumor induction by 2,4 dinitro-1-fluorobenzene in the skin of the TG.AC (v-Ha-ras) mouse. Environ Health Perspect 104, 1062-8.
2. Ando, K., Saitoh, A., Hino, O., Takahashi, R., Kimura, M., and Katsuki, M. (1992). Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes. Cancer Res 52, 978-82.
3. Argyris, T. S. (1985). Regeneration and the mechanism of epidermal tumor promotion. CRC Crit Rev Toxicol 14, 211-58.
4. Battalora, M. S., Spalding, J. W., Szczesniak, C. J., Cape, J. E., Morris, R. J., Trempus, C. S., Bortner, C. D., Lee, B. M., and Tennant, R. W. (2001). Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse. Carcinogenesis 22, 651-9.
5. Boutwell, R. K., Bosch, D., and Rusch, H. P. (1957). On the role of croton oil in tumor formation. Cancer Res 17, 71-5.
6. Cannon, R. E., Spalding, J. W., Trempus, C. S., Szczesniak, C. J., Virgil, K. M., Humble, M. C., and Tennant, R. W. (1997). Kinetics of wound-induced v-Ha-ras transgene expression and papilloma development in transgenic Tg.AC mice. Mol Carcinog 20, 108-14.
7. DiGiovanni, J., Bhatt, T. S., and Walker, S. E. (1993). C57BL/6 mice are resistant to tumor promotion by full thickness skin wounding. Carcinogenesis 14, 319-21.
8. Diwan, B. A., Ward, J. M., Rice, J. M., Colburn, N. H., and Spangler, E. F. (1985). Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin. Carcinogenesis 6, 343-7.
9. Fearon, E. R., Hamilton, S. R., Vogelstein, B. (1987). Clonal analysis of human colorectal tumors. Science 238, 193-7.
10. Goelz, S. E., Vogelstein, B., Hamilton, S. R., and Feinberg, A. P. (1985). Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228, 187-90.
11. Hanausek, M., Walaszek, Z., Viaje, A., LaBate, M., Spears, E., Farrell, D., Henrich, R., Tveit, A., Walborg, E. F., Jr., and Slaga, T. J. (2004). Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential. Carcinogenesis 25, 431-7.
12. Hansen, L. A., Malarkey, D. E., Wilkinson, J. E., Rosenberg, M., Woychik, R. E., and Tennant, R. W. (1998). Effect of the viable-yellow(A(vy)) agouti allele on skin tumorigenesis and humoral hypercalcemia in v-Ha-ras transgenic TGxAC mice. Carcinogenesis 19, 1837-45.
13. Hansen, L. A., and Tennant, R. (1994a). Focal transgene expression associated with papilloma development in v-Ha-ras-transgenic TG.AC mice. Mol Carcinog 9, 143-54.
14. Hansen, L. A., and Tennant, R. W. (1994b). Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin. Proc Natl Acad Sci USA 91, 7822-6.
15. Hansen, L. A., Trempus, C. S., Mahler, J. F., and Tennant, R. W. (1996). Association of tumor development with increased cellular proliferation and transgene overexpression, but not c-Ha-ras mutations, in v-Ha-ras transgenic Tg.AC mice 3. Carcinogenesis 17, 1825-33.
16. Hennings H., and Boutwell R. K. (1970). Studies on the mechanism of skin tumor promotion. Cancer Res 30, 312-20.
17. Humble, M. C., Trempus, C. S., Spalding, J. W., Cannon, R. E., and Tennant, R. W. (2005). Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review. Oncogene 24, 8217-28.
18. Husain, Z., Yang, Q. M., and Biswas, D. K. (1990). cHa-ras proto-oncogene. Amplification and overexpression in UV-B- induced mouse skin papillomas and carcinomas. Arch Dermatol Res 126, 324-30.
19. Law, D. J., Olschwang, S., Monpezat, J. P., Lefrancois, D., Jagelman, D., Petrelli, N. J., Thomas, G., and Feinberg, A. P. (1988). Concerted nonsyntenic allelic loss in human colorectal carcinoma. Science 241, 961-5.
20. Leder, A., Kuo, A., Cardiff, R. D., Sinn, E., and Leder, P. (1990). v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc Natl Acad Sci USA 87, 9178-9182.
21. Lijinsky, W., Thomas, B. J., and Kovatch, R. M. (1991). Differences in skin carcinogenesis by methylnitrosourea between mice of several strains. Cancer Lett 61, 1-5.
22. Meyer, S. A., Moser, G. J., Monteiro-Riviere, N. A., and Smart, R. C. (1993). Minimal role of enhanced cell proliferation in skin tumor promotion by mirex: a nonphorbol ester-type promoter. Environ Health Perspect 101, Suppl 5, 265-9.
23. Morton, D., Alden C. L., Roth A. J., and Usui T. (2002). The Tg rasH2 mouse in cancer hazard identification. Toxicol Pathol 30, 139-46.
24. Moser, G. J., Meyer, S. A., and Smart, R. C. (1992). The chlorinated pesticide mirex is a novel nonphorbol ester-type tumor promoter in mouse skin. Cancer Res 52, 631-6.
25. Murphy, J. E., Morales, R. E., Scott, J., and Kupper, T. S. (2003). IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis. J Immunol 170, 5697-703.
26. Muto, S., Katsuki, M., and Horie, S. (2006). Rapid induction of skin tumors in human but not mouse c-Ha-ras proto-oncogene transgenic mice by chemical carcinogenesis. Cancer Sci 97, 842-7.
27. Nylander-French, L. A., and French, J. E. (1998). Tripropylene glycol diacrylate but not ethyl acrylate induces skin tumors in a twenty-week short-term tumorigenesis study in Tg.AC (v-Ha-ras) mice. Toxicol Pathol 26, 476-83.
28. NTP. (1996). Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1(R)) Mice, and SENCAR Mice. Natl Toxicol Program Tech Rep Ser 441, 1-201.
29. Pritchard, J. B., French, J. E., Davis, B. J., and Haseman, J. K. (2003). The role of transgenic mouse models in carcinogen identification. Environ Health Perspect 111, 444-54.
30. Saitoh, A., Kimura, M., Takahashi, R., Yokoyama, M., Nomura, T., Izawa, M., Sekiya, T., Nishimura, S., and Katsuki, M. (1990). Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5,1195-200.
31. Sistare, F. D., Thompson, K. L., Honchel, R., and DeGeorge, J. (2002). Evaluation of the Tg.AC transgenic mouse assay for testing the human carcinogenic potential of pharmaceuticals-practical pointers, mechanistic clues, and new questions. Int J Toxicol 21, 65-79.
32. Slaga, T. J. (1986). Sencar mouse skin tumorigenesis model versus other strains and stocks of mice. Environ Health Perspect 68, 27-32.
33. Slaga, T. J., Budunova, I. V., Gimenez-Conti, I. B., and Aldaz, C. M. (1996). The mouse skin carcinogenesis model. J Investig Dermatol Symp Proc 1, 151-6.
34. Spalding, J. W., French, J. E., Tice, R. R., Furedi-Machacek, M., Haseman, J. K., and Tennant, R. W. (1999). Development of a transgenic mouse model for carcinogenesis bioassays: evaluation of chemically induced skin tumors in Tg.AC mice. Toxicol Sci 49, 241-54.
35. Spalding, J. W., Momma, J., Elwell, M. R., and Tennant, R. W. (1993). Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene. Carcinogenesis 14, 1335-41.
36. Strickland, J. E., Hennings, H., Jetten, A. M., Yuspa, S. H., Allen, P. T., Hellman, K. B., and Strickland, A. G. 1982. Susceptibility determinants for mouse epidermal carcinogenesis.In: Armstrong B, Bartsch H, eds. Host Factors in Human Carcinogenesis. Lyon: IARC, 259-68.
37. Trempus, C. S., Mahler, J. F., Ananthaswamy, H. N., Loughlin, S. M., French, J. E., and Tennant, R. W. (1998). Photocarcinogenesis and susceptibility to UV radiation in the v-Ha-ras transgenic Tg.AC mouse. J Invest Dermatol 111, 445-51.
38. Usui, T., Mutai, M., Hisada, S., Takoaka, M., Soper, K. A., McCullough, B., and Alden, C. (2001). CB6F1-rasH2 mouse: overview of available data. Toxicol Pathol 29, Suppl, 90-108.
39. Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., Nakamura, Y., White, R., Smits, A. M., and Bos, J. L. (1988). Genetic alterations during colorectal-tumor development. N Engl J Med 319, 525-32.
40. Wojcik, S. M., Bundman, D. S., and Roop, D. R. (2000). Delayed wound healing in keratin 6a knockout mice. Mol Cell Biol 20, 5248-55.
41. Wyde, M. E., Braen, A. P., Hejtmancik, M., Johnson, J. D., Toft, J. D., Blake, J. C., Cooper, S. D., Mahler, J., Vallant, M., Bucher, J. R., and Walker, N. J. (2004). Oral and dermal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cutaneous papillomas and squamous cell carcinomas in female hemizygous Tg.AC transgenic mice. Toxicol Sci 82, 34-45.
42. Yamamoto, S., Urano, K., and Nomura, T. (1998). Validation of transgenic mice harboring the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Toxicol Lett 102-103, 473-8.
43. Yuspa, S. H. (1994). The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis-Thirty-third G.H.A. Clowes Memorial Award Lecture. Cancer Res 54, 1178-89.