Establishment of the reversible peptide-major histocompatibility complex (pMHC) class I Histamer technology: Tool for visualization and selection of functionally active antigen-specific CD8+ T lymphocytes

International Immunology

Volumn 24, Issue 9, 2012, Pages 561-572

  Tischer, Sabine ^a   Kaireit, Till ^a   Figueiredo, Constança ^a   Hiller, Oliver ^a   Maecker Kolhoff, Britta ^a   Geyeregger, Renè ^b   Immenschuh, Stephan ^a   Blasczyk, Rainer ^a   Eiz Vesper, Britta ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

Cytotoxic T lymphocytes; Flow cytometry, human; Immunomagnetic separation; PMHC Histamer

Indexed keywords

HLA A ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ARTICLE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL SELECTION; CELL SEPARATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMAGNETIC SEPARATION; LYMPHOCYTE FUNCTION; PHENOTYPE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ADOPTIVE TRANSFER; CD8-POSITIVE T-LYMPHOCYTES; COBALT; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HISTIDINE; HLA-A2 ANTIGEN; HUMANS; IMMUNOMAGNETIC SEPARATION; IMMUNOPHENOTYPING; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SENSITIVITY AND SPECIFICITY; VIRAL MATRIX PROTEINS;

EID: 84865544825     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxs059     Document Type: Article

References (47)

1. Karlsson, H., Brewin, J., Kinnon, C., Veys, P. and Amrolia, P. J. 2007. Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogens. J. Immunother. 30:544.
2. Moss, P. and Rickinson, A. 2005. Cellular immunotherapy for viral infection after HSC transplantation. Nat. Rev. Immunol. 5:9.
3. Feuchtinger, T., Matthes-Martin, S., Richard, C. et al. 2006. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br. J. Haematol. 134:64.
4. Feuchtinger, T., Opherk, K., Bethge, W. A. et al. 2011. Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation. Blood 116:4360.
5. Heslop, H. E., Ng, C. Y., Li, C. et al. 1996. Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nat. Med. 2:551.
6. Moosmann, A., Bigalke, I., Tischer, J. et al. 2010. Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells. Blood 115:2960.
7. Walter, E. A., Greenberg, P. D., Gilbert, M. J. et al. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333:1038.
8. Fuji, S., Kapp, M., Grigoleit, G. U. and Einsele, H. 2011. Adoptive immunotherapy with virus-specific T cells. Best Pract. Res. Clin. Haematol. 24:413.
9. Chakrabarti, S., Mautner, V., Osman, H. et al. 2002. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood 100:1619.
10. Feuchtinger, T., Lang, P., Hamprecht, K. et al. 2004. Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-gamma secretion for adjuvant immunotherapy. Exp. Hematol. 32:282.
11. Schmitt, A., Tonn, T., Busch, D. H. et al. 2011. Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation. Transfusion 51:591.
12. Bakker, A. H. and Schumacher, T. N. 2005. MHC multimer technology: current status and future prospects. Curr. Opin. Immunol. 17:428.
13. Casalegno-Garduno, R., Schmitt, A., Yao, J. et al. 2010. Multimer technologies for detection and adoptive transfer of antigen-specific T cells. Cancer Immunol. Immunother. 59:195.
14. Hadrup, S. R., Bakker, A. H., Shu, C. J. et al. 2009. Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers. Nat. Methods 6:520.
15. Hugues, S., Malherbe, L., Filippi, C. and Glaichenhaus, N. 2002. Generation and use of alternative multimers of peptide/MHC complexes. J. Immunol. Methods 268:83.
16. Newell, E. W., Klein, L. O., Yu, W. and Davis, M. M. 2009. Simultaneous detection of many T-cell specificities using combinatorial tetramer staining. Nat. Methods 6:497.
17. Altman, J. D., Moss, P. A., Goulder, P. J. et al. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94.
18. Cole, D. K., Pumphrey, N. J., Boulter, J. M. et al. 2007. Human TCR-binding affinity is governed by MHC class restriction. J. Immunol. 178:5727.
19. Dal Porto, J., Johansen, T. E., Catipovic, B. et al. 1993. A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc. Natl. Acad. Sci. USA 90:6671.
20. Schneck, J. P. 2000. Monitoring antigen-specific T cells using MHC-Ig dimers. Immunol. Invest. 29:163.
21. Wooldridge, L., Lissina, A., Cole, D. K., van den Berg, H. A., Price, D. A. and Sewell, A. K. 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126:147.
22. Duplan, V., Suberbielle, E., Napper, C. E., Joly, E., Saoudi, A. and Gonzalez-Dunia, D. 2007. Tracking antigen-specific CD8+ T cells in the rat using MHC class I multimers. J. Immunol. Methods 320:30.
23. Savage, P., Millrain, M., Dimakou, S., Stebbing, J. and Dyson, J. 2007. Expansion of CD8+ cytotoxic T cells in vitro and in vivo using MHC class I tetramers. Tumour Biol. 28:70.
24. Svensson, S., Olin, A. C., Larstad, M., Ljungkvist, G. and Toren, K. 2004. Determination of hydrogen peroxide in exhaled breath condensate by flow injection analysis with fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 809:199.
25. Batard, P., Peterson, D. A., Devevre, E. et al. 2006. Dextramers: new generation of fluorescent MHC class I/peptide multimers for visualization of antigen-specific CD8+ T cells. J. Immunol. Methods 310:136.
26. Guillaume, P., Legler, D. F., Boucheron, N., Doucey, M. A., Cerottini, J. C. and Luescher, I. F. 2003. Soluble major histocompatibility complex-peptide octamers with impaired CD8 binding selectively induce Fas-dependent apoptosis. J. Biol. Chem. 278:4500.
27. Knabel, M., Franz, T. J., Schiemann, M. et al. 2002. Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nat. Med. 8:631.
28. Bouquie, R., Bonnin, A., Bernardeau, K. et al. 2009. A fast and efficient HLA multimer-based sorting procedure that induces little apoptosis to isolate clinical grade human tumor specific T lymphocytes. Cancer Immunol. Immunother. 58:553.
29. Labarriere, N., Gervois, N., Bonnin, A., Bouquie, R., Jotereau, F. and Lang, F. 2008. PBMC are as good a source of tumor-reactive T lymphocytes as TIL after selection by Melan-A/A2 multimer immunomagnetic sorting. Cancer Immunol. Immunother. 57:185.
30. Constantin, C. M., Bonney, E. E., Altman, J. D. and Strickland, O. L. 2002. Major histocompatibility complex (MHC) tetramer technology: an evaluation. Biol. Res. Nurs. 4:115.
31. Einsele, H., Kapp, M. and Grigoleit, G. U. 2008. CMV-specific T cell therapy. Blood Cells Mol. Dis. 40:71.
32. Pedron, B., Guerin, V., Jacquemard, F. et al. 2007. Comparison of CD8+ T Cell responses to cytomegalovirus between human fetuses and their transmitter mothers. J. Infect. Dis. 196:1033.
33. Yao, J., Bechter, C., Wiesneth, M. et al. 2008. Multimer staining of cytomegalovirus phosphoprotein 65-specific T cells for diagnosis and therapeutic purposes: a comparative study. Clin. Infect. Dis. 46:e96.
34. Solache, A., Morgan, C. L., Dodi, A. I. et al. 1999. Identification of three HLA-A*0201-restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus. J. Immunol. 163:5512.
35. Aissi-Rothe, L., Decot, V., Venard, V. et al. 2010. Rapid generation of full clinical-grade human antiadenovirus cytotoxic T cells for adoptive immunotherapy. J. Immunother. 33:414.
36. Paine, A., Oelke, M., Tischer, S., Heuft, H. G., Blasczyk, R. and Eiz-Vesper, B. 2010. Soluble recombinant CMVpp65 spanning multiple HLA alleles for reconstitution of antiviral CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation. J. Immunother. 33:60.
37. Sato, Y., Sahara, H., Tsukahara, T. et al. 2002. Improved generation of HLA class I/peptide tetramers. J. Immunol. Methods 271:177.
38. Jedema, I., van der Werff, N. M., Barge, R. M., Willemze, R. and Falkenburg, J. H. 2004. New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population. Blood 103:2677.
39. Neudorfer, J., Schmidt, B., Huster, K. M. et al. 2007. Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens. J. Immunol. Methods 320:119.
40. Davis, M. M., Boniface, J. J., Reich, Z. et al. 1998. Ligand recognition by alpha beta T cell receptors. Annu. Rev. Immunol. 16:523.
41. Boniface, J. J., Rabinowitz, J. D., Wulfing, C. et al. 1998. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]. Immunity 9:459.
42. Cochran, J. R., Cameron, T. O. and Stern, L. J. 2000. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 12:241.
43. Clair, T., Koh, E., Ptaszynska, M. et al. 2005. L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin. Lipids Health Dis. 4:5.
44. Millward, D. J. 1997. Human amino acid requirements. J. Nutr. 127:1842.
45. Takeuchi, K., Maida, K., Yoshida, S., Suzuki, S., del Nido, P. J. and Tanaka, S. 1997. A clinical application of histidine buffered cardioplegia. Nippon Kyobu Geka Gakkai Zasshi 45:1715.
46. Rauser, G., Einsele, H., Sinzger, C. et al. 2004. Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood 103:3565.
47. Pahl-Seibert, M. F., Juelch, M., Podlech, J. et al. 2005. Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting. J. Virol. 79:5400.