Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation

Blood

Volumn 116, Issue 20, 2010, Pages 4360-4367

  Feuchtinger, Tobias ^a   Opherk, Kathrin ^a   Bethge, Wolfgang A ^b   Topp, Max S ^a,c   Schuster, Friedhelm R ^d   Weissinger, Eva M ^e   Mohty, Mohamad ^f   Or, Reuven ^g   Maschan, Michael ^h   Schumm, Michael ^a   Hamprecht, Klaus ^b   Handgretinger, Rupert ^a   Lang, Peter ^a   Einsele, Hermann ^c  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f UNIVERSITÉ DE NANTES   (France)

^g HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^h Russian Children's Hospital   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTIVIRUS AGENT; BUSULFAN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CIDOFOVIR; CLOFARABINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOMEGALOVIRUS ANTIGEN PP65; ETANERCEPT; FLUDARABINE; FOSCARNET; FOSCARNET SODIUM; GAMMA INTERFERON; GANCICLOVIR; HLA ANTIGEN; LEUKOCYTE ANTIGEN; MELPHALAN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISOLONE; TACROLIMUS; THIOTEPA; THYMOCYTE ANTIBODY; TREOSULFAN; VALGANCICLOVIR;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADOPTIVE TRANSFER; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA; CELL EXPANSION; CELL ISOLATION; CELL SPECIFICITY; CELL STIMULATION; CELL THERAPY; CELL TRANSFER; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; JUVENILE MYELOMONOCYTIC LEUKEMIA; LYMPH NODE IRRADIATION; MALE; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SCHOOL CHILD; T LYMPHOCYTE; TAY SACHS DISEASE; VIREMIA; VIRUS ENCEPHALITIS; VIRUS IMMUNITY; VIRUS LOAD; VIRUS REACTIVATION;

EID: 78549241330     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-01-262089     Document Type: Article

References (27)

1. Handgretinger R, Lang P, Schumm M, et al. Immunological aspects of haploidentical stem cell transplantation in children. Ann N Y Acad Sci. 2001;938:340-357.
2. Lang P, Handgretinger R, Niethammer D, et al. Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia. Blood. 2003;101(4):1630-1636. (Pubitemid 36182544)
3. Mohty M, Jacot W, Faucher C, et al. Infectious complications following allogeneic HLA-identical sibling transplantation with antithymocyte globulin-based reduced intensity preparative regimen. Leukemia. 2003;17(11):2168-2177. (Pubitemid 37428382)
4. Lewin SR, Heller G, Zhang L, et al. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood. 2002;100(6):2235-2242. (Pubitemid 35001261)
5. Bahceci E, Epperson D, Douek DC, Melenhorst JJ, Childs RC, Barrett AJ. Early reconstitution of the T-cell repertoire after non-myeloablative peripheral blood stem cell transplantation is from postthymic T-cell expansion and is unaffected by graft-versus-host disease or mixed chimaerism. Br J Haematol. 2003;122(6):934-943.
6. Ljungman P, Brand R, Einsele H, Frassoni F, Niederwieser D, Cordonnier C. Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis. Blood. 2003;102(13):4255-4260.
7. Boeckh M, Nichols WG. The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy. Blood. 2004;103(6):2003-2008. (Pubitemid 38326213)
8. Rooney CM, Smith CA, Ng CY, et al. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood. 1998;92(5):1549-1555.
9. Walter EA, Greenberg PD, Gilbert MJ, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med. 1995;333(16):1038-1044.
10. Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002;99(11):3916-3922.
11. Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science. 1992;257(5067):238-241.
12. Bollard CM, Straathof KC, Huls MH, et al. The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease. J Immunother. 2004;27(4):317-327.
13. Peggs KS, Verfuerth S, Pizzey A, et al. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet. 2003;362(9393):1375-1377.
14. Sun JC, Williams MA, Bevan MJ. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol. 2004;5(9):927-933.
15. Bevan MJ. Helping the CD8(+) T-cell response. Nat Rev Immunol. 2004;4(8):595-602.
16. Feuchtinger T, Lang P, Hamprecht K, et al. Isolation and expansion of human adenovirus specific CD4+ and CD8+ T-cells according to IFN-gamma secretion for adjuvant immunotherapy. Exp Hematol. 2004;32(3):282-289. (Pubitemid 38328534)
17. Feuchtinger T, Matthes-Martin S, Richard C, et al. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2006;134(1):64-76.
18. Rauser G, Einsele H, Sinzger C, et al. Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood. 2004;103(9):3565-3572.
19. Schottker B, Feuchtinger T, Schumm M, et al. Five donors-one recipient: modeling a mosaic of granulocytes, natural killer and T cells from cord-blood and third-party donors. Nat Clin Pract Oncol. 2008;5(5):291-295. (Pubitemid 351594145)
20. Feuchtinger T, Richard C, Joachim S, et al. Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation. J Immunother. 2008;31(2):199-206.
21. Gattinoni L, Klebanoff CA, Palmer DC, et al. Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J Clin Invest. 2005;115(6):1616-1626. (Pubitemid 40814670)
22. Leen AM, Myers GD, Sili U, et al. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med. 2006;12(10):1160-1166. (Pubitemid 44527351)
23. Stemberger C, Huster KM, Koffler M, et al. A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. Immunity. 2007;27(6):985-997. (Pubitemid 50014865)
24. Reddehase MJ. Antigens and immunoevasins: opponents in cytomegalovirus immune surveillance. Nat Rev Immunol. 2002;2(11):831-844.
25. Yao J, Bechter C, Wiesneth M, et al. Multimer staining of cytomegalovirus phosphoprotein 65-specific T cells for diagnosis and therapeutic purposes: a comparative study. Clin Infect Dis. 2008;46(10):e96-e105.
26. Fujita Y, Leen AM, Sun J, et al. Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy. J Immunother. 2008;31(7):665-674.
27. Hunder NN, Wallen H, Cao J, et al. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N Engl J Med. 2008;358(25):2698-2703.