A single nucleotide polymorphism in the CYP2E1 gene promoter affects skatole content in backfat of boars of two commercial Duroc-sired crossbred populations

Meat Science

Volumn 92, Issue 4, 2012, Pages 739-744

  Mörlein, Daniel ^a   Lungershausen, Mara ^a   Steinke, Kirsten ^a   Sharifi, Ahmad Reza ^a   Knorr, Christoph ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Boar taint; Consumer acceptance; CYP2E1; Cytochrome p450; Marker assisted selection; Skatole

Indexed keywords

BOAR TAINT; CONSUMER ACCEPTANCE; CYP2E1; CYTOCHROME P450; MARKER-ASSISTED SELECTION; SKATOLE;

GENES;

NUCLEOTIDES;

SUIDAE; SUS;

ANDROST 16 EN 3 ONE; ANDROST-16-EN-3-ONE; ANDROSTANE DERIVATIVE; CYTOCHROME P450 2E1; PHEROMONE; SKATOLE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BACK; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; CROSS BREEDING; FAT INTAKE; FOOD CONTAMINATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETICS; GERMANY; HOMOZYGOTE; MALE; METABOLISM; ODOR; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, WHITE; ANDROSTENES; ANIMALS; BACK; CROSSES, GENETIC; CYTOCHROME P-450 CYP2E1; DIETARY FATS; FOOD CONTAMINATION; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GERMANY; HOMOZYGOTE; MALE; MODELS, BIOLOGICAL; ODORS; PHEROMONES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SKATOLE; SUS SCROFA;

EID: 84865539180     PISSN: 03091740     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meatsci.2012.06.031     Document Type: Article

References (36)

1. Ampuero Kragten S., Verkuylen B., Dahlmans H., Hortos M., Garcia-Regueiro J.a, Dahl E., et al. Inter-laboratory comparison of methods to measure androstenone in pork fat. Animal 2011, 5(10):1634-1642.
2. Babol J., Zamaratskaia G., Juneja R.K., Lundström K. The effect of age on distribution of skatole and indole levels in entire male pigs in four breeds: Yorkshire, Landrace, Hampshire and Duroc. Meat Science 2004, 67(2):351-358.
3. Bonneau M., Chevillon P. Acceptability of entire male pork with various levels of androstenone and skatole by consumers according to their sensitivity to androstenone. Meat Science 2012, 90(2):330-337.
4. Claus R., Weiler U., Herzog A. Physiological aspects of androstenone and skatole formation in the boar-A review with experimental data. Meat Science 1994, 38(2):289-305.
5. Collins F.S. Positional cloning: Let's not call it reverse anymore. Nature Genetics 1992, 1(1):3-6.
6. Diaz G.J., Squires E.J. Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver. Xenobiotica 2003, 33(5):485-498.
7. Doran E., Whittington F.W., Wood J.D., McGivan J.D. Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chemico-Biological Interactions 2002, 140(1):81-92.
8. European Declaration on alternatives to surgical castration Retrieved September 14, 2011, from. http://ec.europa.eu/food/animal/welfare/farm/initiatives_en.htm.
9. Gandolfi G., Cinar M.U., Ponsuksili S., Wimmers K., Tesfaye D., Looft C., et al. Association of PPARGC1A and CAPNS1 gene polymorphisms and expression with meat quality traits in pigs. Meat Science 2011, 89(4):478-485.
10. Gregersen V.R., Conley L.N., Sorensen K.K., Guldbrandtsen B., Velander I.H., Bendixen C. Genome-wide association scan and phased haplotype construction for quantitative trait loci affecting boar taint in three pig breeds. BMC Genomics 2012, 13(1):22.
11. Grindflek E., Lien S., Hamland H., Hansen M.H., Kent M., Van Son M., et al. Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids. BMC Genomics 2011, 12(1):362.
12. Grindflek E., Meuwissen T.H.E., Aasmundstad T., Hamland H., Hansen M.H.S., Nome T., et al. Revealing genetic relationships between compounds affecting boar taint and reproduction in pigs. Journal of Animal Science 2011, 89(3):680-692.
13. Gross-Bellard M., Oudet P., Chambon P. Isolation of high-molecular-weight DNA from mammalian cells. European Journal of Biochemistry/ FEBS 1973, 36(1):32-38.
14. Haugen J., Brunius C., Zamaratskaia G. Review of analytical methods to measure boar taint compounds in porcine adipose tissue: The need for harmonised methods. Meat Science 2012, 90(1):9-19.
15. Jensen B.B. Prevention of boar taint in pig production Factors affecting the level of skatole. Acta Veterinaria Scandinavica 2006, 48(Suppl. 1):S6.
16. Jensen M.T., Cox R.P., Jensen B.B. 3-Methylindole (skatole) and indole production by mixed populations of pig fecal bacteria. Applied and Environmental Microbiology 1995, 61(8):3180-3184.
17. Lee G.J., Archibald A., Law A., Lloyd S., Wood J., Haley C. Detection of quantitative trait loci for androstenone, skatole and boar taint in a cross between Large White and Meishan pigs. Animal Genetics 2004, 36(1):14-22.
18. Lin Z., Lou Y., Squires E.J. Molecular cloning, expression and functional characterization of the cytochrome P450 2A6 gene in pig liver. Animal Genetics 2004, 35(4):314-316.
19. Lin Z., Lou Y., Squires J. Molecular cloning and functional analysis of porcine SULT1A1 gene and its variant: A single mutation SULT1A1 causes a significant decrease in sulfation activity. Mammalian Genome 2004, 15(3):218-226.
20. Lunde K., Skuterud E., Hersleth M., Egelandsdal B. Norwegian consumers' acceptability of boar tainted meat with different levels of androstenone or skatole as related to their androstenone sensitivity. Meat Science 2010, 86(3):706-711.
21. Lundström K., Malmfors B., Malmfors G., Stern S., Petersson H., Mortensen A.B., et al. Skatole, androstenone and taint in boars fed two different diets. Livestock Production Science 1988, 18:55-67.
22. Lundström K., Malmfors B., Stern S., Rydhmer L., Eliasson-Selling L., Mortensen A.B., et al. Skatole levels in pigs selected for high lean tissue growth rate on different dietary protein levels. Livestock Production Science 1994, 38:125-132.
23. Lundström K., Matthews K.R., Haugen J.E. Pig meat quality from entire males. Animal 2009, 3(11):1497-1507.
24. Moe M., Lien S., Aasmundstad T., Meuwissen T.H.E., Hansen M.H.S., Bendixen C., et al. Association between SNPs within candidate genes and compounds related to boar taint and reproduction. BMC Genetics 2009, 10:32.
25. Mörlein D., Grave A., Sharifi A.R., Bücking M., Wicke M. Different scalding techniques do not affect boar taint. Meat Science 2012, 91:435-440.
26. Neupert B., Claus R., Herbert E., Weiler U. Einfluss von Geschlecht, Fütterung und Lichtprogrammen auf Mastleistung und Schlachtkörperwert sowie die Androstenon- und Skatolbildung beim Schwein. Züchtungskunde 1995, 67:317-331.
27. Ramos A.M., Duijvesteijn N., Knol E.F., Merks J.W., Bovenhuis H., Crooijmans R.P., et al. The distal end of porcine chromosome 6p is involved in the regulation of skatole levels in boars. BMC Genetics 2011, 12:35.
28. Rasmussen M.K., Zamaratskaia G., Ekstrand B. Gender-related differences in cytochrome P450 in porcine liver-Implication for activity, expression and inhibition by testicular steroids. Reproduction in Domestic Animals. Zuchthygiene 2011, 46(4):616-623.
29. Robic A., Larzul C., Bonneau M. Genetic and metabolic aspects of androstenone and skatole deposition in pig adipose tissue: A review. Genetics Selection Evolution 2008, 40(1):129-1143.
30. Skinner T.M., Doran E., McGivan J.D., Haley C.S., Archibald A.L. Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig. Animal Genetics 2005, 36(5):417-422.
31. Squires E., Lundström K. Relationship between cytochrome P450IIE1 in liver and levels of skatole and its metabolites in intact male pigs. Journal of Animal Science 1997, 75(9):2506-2511.
32. Tajet H., Andresen Ø., Meuwissen T.H.E. Estimation of genetic parameters of boar taint; skatole and androstenone and their correlations with sexual maturation. Acta Veterinaria Scandinavica 2006, 4:5-8.
33. Trautmann J., Meier-Dinkel L., Gardemin C., Frieden L., Tholen E., Knorr C., et al. Consumer perception of meat from boar pigs as affected by labeling and malodorous. 61st EAAP meeting, Stavanger, Norway 2011.
34. Varona L., Vidal O., Quintanilla R., Gil M., Sanchez A., Folch J., et al. Bayesian analysis of quantitative trait loci for boar taint in a Landrace outbred population. Journal of Animal Science 2005, 83(2):301-307.
35. Yokoyama M.T., Carlson J.R. Microbial metabolites of tryptophan in the intestinal tract with special reference to skatole. The American Journal of Clinical Nutrition 1979, 32(1):173-178.
36. Zamaratskaia G., Squires E. Biochemical, nutritional and genetic effects on boar taint in entire male pigs. Animal 2009, 3(11):1508-1521.