Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig

Animal Genetics

Volumn 36, Issue 5, 2005, Pages 417-422

  Skinner, T M ^a   Doran, E ^b   McGivan, J D ^b   Haley, C S ^a   Archibald, A L ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

cytochrome p450 2E1; Porcine; Single nucleotide polymorphism; Skatole; SSC14

Indexed keywords

SUIDAE; SUS SCROFA; SUS SCROFA DOMESTICA;

CYTOCHROME P450 2E1; MICROSATELLITE DNA; PRIMER DNA; SKATOLE;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CHROMOSOME MAP; COMPARATIVE STUDY; CROSS BREEDING; DNA SEQUENCE; GENE FREQUENCY; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE;

ADIPOSE TISSUE; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CLONING, MOLECULAR; CROSSES, GENETIC; CYTOCHROME P-450 CYP2E1; DNA PRIMERS; GENE FREQUENCY; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; SKATOLE; SUS SCROFA;

EID: 33644878044     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2005.01342.x     Document Type: Article

References (26)

1. Agergaard N. Laue A. (1993) Absorption from the gastrointestinal tract and liver turnover of skatole. In: Measurement and Prevention of Boar Taint in Intact Male Pigs (Ed. by M. Bonneau pp. 107 11. INRA Edition, Paris, France.
2. Anderson S.I., Lopez-Corrales N.L., Gorick B. Archibald A.L. (2000) A large fragment genomic library resource in a BAC vector. Mammalian Genome 11, 811 814.
3. Babol J., Squires E.J. Lundstrom K. (1998a) Hepatic metabolism of skatole in pigs by cytochrome P4502E1. Journal of Animal Science 76, 822 8.
4. Babol J., Squires E.J. Lundstrom K. (1998b) Relationship between oxidation and conjugation metabolism of skatole in pig liver and concentrations of skatole in fat. Journal of Animal Science 76, 829 38.
5. Church G.M. Gilbert W. (1984) Genomic sequencing. Proceedings of the National Academy of Sciences of the United States of America 81, 1991 5.
6. Claus R., Weiler U. Herzog A. (1994) Physiological aspects of androstenone and skatole formation in the boar - a review with experimental data. Meat Science 38, 289 305.
7. Dehnhard M., Bernal-Barragan H. Claus R. (1991) Rapid and accurate high-performance liquid chromatographic method for the determination of 3-methylindole (skatole) in faeces of various species. Journal of Chromatography 566, 101 7.
8. Doran E., Whittington F.W., Wood J.D. McGivan J.D. (2002) Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chemico-Biological Interactions 140, 81 92.
9. Fahrenkrug S.C., Rohrer G.A., Freking B.A., Smith T.P., Osoegawa K., Shu C.L., Catanese J.J. de Jong P.J. (2001) A porcine BAC library with tenfold genome coverage: a resource for physical and genetic map integration. Mammalian Genome 12, 472 4.
10. Green P., Falls K. Crooks S. (1990) Documentation for CRI-MAP, version 2.4. Washington University School of Medicine, St Louis, MO, USA.
11. Knudson B.K., Hogberg M.G., Merkel R.A., Allen R.E. Magee W.T. (1985) Developmental comparisons of boars and barrows: I. Growth rate, carcass and muscle characteristics. Journal of Animal Science 61, 789 96.
12. Kouba M., Enser M., Whittington F.M., Nute G.R. Wood J.D. (2003) Effect of a high-linolenic acid diet on lipogenic enzyme activities, fatty acid composition, and meat quality in the growing pig. Journal of Animal Science 81, 1967 79.
13. Lee G.J., Archibald A.L., Law A.S., Lloyd S., Wood J. Haley C. S. (2005) Detection of quantitative trait loci for androstenone, skatole and boar taint in a cross between Large White and Meishan pigs. Animal Genetics 36, 14 22.
14. Loots G.G., Ovcharenko I., Pachter L., Dubchak I. Rubin E.M. (2002) rVista for comparative sequence-based discovery of functional transcription factor binding sites. Genome Research 12, 832 9.
15. Lundstrom K., Malmfors B., Stern S., Rydhmer L., Eliasson-Selling L., Mortensen A. B. Mortensen H.P. (1994) Skatole levels in pigs selected for high lean tissue growth rate on different dietary protein levels. Livestock Production Science 38, 125 32.
16. Matise T.C., Perlin M. Chakravarti A. (1994) Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Nature Genetics 6, 384 90.
17. Nonneman D. Rohrer G.A. (2004) Comparative mapping of human chromosome 10 to pig chromosomes 10 and 14. Animal Genetics 35, 338 43.
18. Odom D.T., Zizlsperger N., Gordon D.B. et al. (2004) Control of pancreas and liver gene expression by HNF transcription factors. Science 303, 1378 81.
19. Peng H.M. Coon M.J. (2000) Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2. Archives of Biochemistry and Biophysics 382, 129 37.
20. Quintanilla R., Demeure O., Bidanal J.P., Milan D., Iannuccelli N., Amigues Y., Gruand J., Renard C., Chevalet C. Bonneau M. (2003) Detection of quantitative trait loci for fat levels in pigs. Journal of Animal Science 81, 385 94.
21. Skinner T.M., Lopez-Corrales N.L., Anderson S.I., Loudon A.S., Lowden S., Haley C.S. Archibald A.L. (2001) Genetic and physical mapping, expression analysis and partial sequence of porcine PER1. Cytogenetics and Cell Genetics 95, 82 4.
22. Squires E.J. Lundstrom K. (1997) Relationship between cytochrome P4502E1 in liver and level of skatole and its metabolites in intact male pigs. Journal of Animal Scinece 75, 2506 11.
23. Tambyrajah W.S., Doran E., Wood J.D. McGivan J.D. (2004) The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone. Archives of Biochemistry and Biophysics 431, 252 260.
24. Ueno T. Gonzalez F.J. (1990) Transcriptional control of the rat hepatic CYP2E1 gene. Molecular and Cell Biology 10, 4495 505.
25. Xue J., Dial G.D., Holton E.E., Vickers Z., Squires E.J., Lou Y., Godbout D. Morel N. (1996) Breed differences in boar taint: relationship between tissue levels boar taint compounds and sensory analysis of taint. Journal of Animal Science 74, 2170 7.
26. Yokoyama M.T. Carlson J.R. (1979) Microbial metabolites of tryptophan in the intestinal tract with special reference to skatole. American Journal of Clinical Nutrition 32, 173 9.