Myeloid-specific expression of Stat3C results in conversion of bone marrow mesenchymal stem cells into alveolar type II epithelial cells in the lung

Science China Life Sciences

Volumn 55, Issue 7, 2012, Pages 576-590

  Yan, Cong ^a,b   Qu, Peng ^a,b   Du, Hong ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

lung epithelial cells; mesenchymal stem cells; myeloid derived suppressive cells (MDSCs); Stat3C; tissue remodeling; transgenic mice

Indexed keywords

STAT3 PROTEIN; STAT3 PROTEIN, MOUSE;

ANIMAL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CYTOLOGY; EPITHELIUM CELL; FLOW CYTOMETRY; IMMUNOELECTRON MICROSCOPY; LUNG ALVEOLUS; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; EPITHELIAL CELLS; FLOW CYTOMETRY; MESENCHYMAL STROMAL CELLS; MICE; MICE, TRANSGENIC; MICROSCOPY, IMMUNOELECTRON; PULMONARY ALVEOLI; REAL-TIME POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR;

MUS; MUS MUSCULUS;

EID: 84865523073     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-012-4339-2     Document Type: Article

References (45)

1. Whitsett J A, Weaver T E. Hydrophobic surfactant proteins in lung function and disease. N Engl J Med, 2002, 347: 2141-2148.
2. Yan C, Du H. Alveolus formation: what have we learned from genetic studies? J Appl Physiol, 2004, 97: 1543-1548.
3. Bishop A E. Pulmonary epithelial stem cells. Cell Prolif, 2004, 37: 89-96.
4. Williams M C. Alveolar type I cells: molecular phenotype and development. Annu Rev Physiol, 2003, 65: 669-695.
5. Mason R J, Williams M C, Moses H L, et al. Stem cells in lung development, disease, and therapy. Am J Respir Cell Mol Biol, 1997, 16: 355-363.
6. Weiss D J, Kolls J K, Ortiz L A, et al. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc, 2008, 5: 637-667.
7. Yan C, Lian X, Dai Y, et al. Gene delivery by the hSP-B promoter to lung alveolar type II epithelial cells in LAL-knockout mice through bone marrow mesenchymal stem cells. Gene Ther, 2007, 14: 1461-1470.
8. -/- mice. Am J Pathol, 2006, 169: 916-926.
9. -/- mice. J Immunol, 2011, 187: 3854-3866.
10. Qu P, Du H, Li Y, et al. Myeloid-specific expression of Api6/ AIM/Sp alpha induces systemic inflammation and adenocarcinoma in the lung. J Immunol, 2009, 182: 1648-1659.
11. Qu P, Yan C, Du H. Matrix metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis. Blood, 2011, 117: 4476-4489.
12. Wu L, Yan C, Czader M, et al. Inhibition of PPARgamma in myeloid-lineage cells induces systemic inflammation, immuno-suppression, and tumorigenesis. Blood, 2012, 119: 115-126.
13. Akira S, Nishio Y, Inoue M, et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell, 1994, 77: 63-71.
14. Wegenka U M, Lutticken C, Buschmann J, et al. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol Cell Biol, 1994, 14: 3186-3196.
15. Zhong Z, Wen Z, Darnell J E Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science, 1994, 264: 95-98.
16. Leonard W J, O'shea J J. Jaks and STATs: biological implications. Annu Rev Immunol, 1998, 16: 293-322.
17. Taga T, Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol, 1997, 15: 797-819.
18. Li Y, Du H, Qin Y, et al. Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung. Cancer Res, 2007, 67: 8494-8503.
19. Wu L, Du H, Li Y, et al. Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expansion and immune suppression during lung tumorigenesis. Am J Pathol, 2011, 179: 2131-2141.
20. Bromberg J F, Wrzeszczynska M H, Devgan G, et al. Stat3 as an oncogene. Cell, 1999, 98: 295-303.
21. Hevehan D L, Miller W M, Papoutsakis E T. Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Blood, 2002, 99: 1627-1637.
22. Sasmono R T, Oceandy D, Pollard J W, et al. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood, 2003, 101: 1155-1163.
23. Lian X, Qin Y, Hossain S A, et al. Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury. J Immunol, 2005, 174: 7250-7256.
24. Wu L, Wang G, Qu P, et al. Overexpression of dominant negative peroxisome proliferator-activated receptor-gamma (PPARgamma) in alveolar type II epithelial cells causes inflammation and T-cell suppression in the lung. Am J Pathol, 2011, 178: 2191-2204.
25. Qu P, Shelley W C, Yoder M C, et al. Critical roles of lysosomal acid lipase in myelopoiesis. Am J Pathol, 2010, 176: 2394-2404.
26. Qu P, Du H, Wilkes D S, et al. Critical roles of lysosomal acid lipase in T cell development and function. Am J Pathol, 2009, 174: 944-956.
27. Du H, Duanmu M, Witte D, et al. Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage. Hum Mol Genet, 1998, 7: 1347-1354.
28. Lian X, Yan C, Yang L, et al. Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am J Physiol Lung Cell Mol Physiol, 2004, 286: L801-807.
29. Lian X, Yan C, Qin Y, et al. Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice. Am J Pathol, 2005, 167: 813-821.
30. Baddoo M, Hill K, Wilkinson R, et al. Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem, 2003, 89: 1235-1249.
31. Sackstein R, Merzaban J S, Cain D W, et al. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med, 2008, 14: 181-187.
32. Anjos-Afonso F, Bonnet D. Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment. Blood, 2007, 109: 1298-1306.
33. Qu P, Du H, Li Y, et al. Myeloid-specific expression of Api6/AIM/ Sp{alpha} induces systemic inflammation and adenocarcinoma in the lung. J Immunol, 2009, 182: 1648-1659.
34. Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest, 2007, 117: 1155-1166.
35. Gabrilovich D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol, 2004, 4: 941-952.
36. Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol, 2009, 182: 4499-4506.
37. Satoh M, Mioh H, Shiotsu Y, et al. Mouse bone marrow stromal cell line MC3T3-G2/PA6 with hematopoietic-supporting activity expresses high levels of stem cell antigen Sca-1. Exp Hematol, 1997, 25: 972-979.
38. Rodriguez Mdel C, Bernad A, Aracil M. Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective hematopoietic support. Blood, 2004, 103: 3349-3354.
39. Tanaka-Douzono M, Suzu S, Yamada M, et al. Detection of murine adult bone marrow stroma-initiating cells in Lin(-)c-fms(+)c-kit(low)VCAM-1(+) cells. J Cell Physiol, 2001, 189: 45-53.
40. Gebe J A, Llewellyn M, Hoggatt H, et al. Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha. Immunology, 2000, 99: 78-86.
41. Miyazaki T, Hirokami Y, Matsuhashi N, et al. Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. J Exp Med, 1999, 189: 413-422.
42. Li Y, Qu P, Wu L, et al. Api6/AIM/Spalpha/CD5L overexpression in alveolar type II epithelial cells induces spontaneous lung adenocarcinoma. Cancer Res, 2011, 71: 5488-5499.
43. Taraseviciene-Stewart L, Voelkel N F. Molecular pathogenesis of emphysema. J Clin Invest, 2008, 118: 394-402.
44. Alison M R, Lim S, Houghton J M. Bone marrow-derived cells and epithelial tumours: more than just an inflammatory relationship. Curr Opin Oncol, 2009, 21: 77-82.
45. Djouad F, Plence P, Bony C, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood, 2003, 102: 3837-3844.