A novel polypeptide extracted from Ciona savignyi induces apoptosis through a mitochondrial-mediated pathway in human colorectal carcinoma cells

Clinical Colorectal Cancer

Volumn 11, Issue 3, 2012, Pages 207-214

  Cheng, Linyou ^a,b   Wang, Chunguang ^c   Liu, Haizhou ^a   Wang, Fengxia ^a   Zheng, Lanhong ^a   Zhao, Jin ^a   Chu, Edward ^d   Lin, Xiukun ^a  

^a INSTITUTE OF OCEANOLOGY   (China)

^b Shandong Academy of Pharmaceutical Science   (China)

^c TONGJI UNIVERSITY   (China)

^d UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Antitumor; Ciona savignyi; Polypeptide; Purification and identification

Indexed keywords

ACETONE; ANTINEOPLASTIC AGENT; POLYPEPTIDE;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCIDIACEA; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CIONA SAVIGNYI; COLORECTAL CARCINOMA; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG ISOLATION; FRACTIONATION; GEL CHROMATOGRAPHY; GENOME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MITOCHONDRION; MOLECULAR WEIGHT; ULTRAFILTRATION; WESTERN BLOTTING;

EID: 84865504525     PISSN: 15330028     EISSN: 19380674     Source Type: Journal    
DOI: 10.1016/j.clcc.2012.01.002     Document Type: Article

References (26)

1. Y.S. Khotimchenko Antitumor properties of nonstarch polysaccharides: Fucoidans and chitosans Russ J Mar Biol 36 2010 321 330
2. J.W. Blunt, B.R. Copp, W. Hu Marine natural products Nat Prod Rep 25 2008 85 94
3. D.J. Newman, G.M. Cragg Marine natural products and related compounds in clinical and advanced preclinical trials J Nat Prod 67 2004 1216 1238
4. M.D. Lebar, J.L. Heimbegner, B.J. Baker Cold-water marine natural products Nat Prod Rep 24 2007 774 797
5. K.L. Rinehart Antitumor compounds from tunicates Med Res Rev 20 2000 1 27
6. D.J. Newman, G.M. Cragg Advanced preclinical and clinical trials of natural products and related compounds from marine sources Curr Med Chem 11 2004 1693 1713
7. A. Jemal, R. Siegel, E. Ward Cancer statistics CA Cancer J Clin 2008 2008 71 96 )
8. M.J. Sewitch, C. Fournier, A. Ciampi Adherence to colorectal cancer screening guidelines in Canada BMC Gastroenterol 7 2007 39 47
9. M.W. Yeazel, T.R. Church, R.M. Jones Colorectal cancer screening adherence in a general population Cancer Epidemiol Biomarkers Prev 13 2004 654 657
10. American Cancer Society Cancer Facts & Figures 2008 http://www.cancer.org/Research/CancerFactsFigures/cancer-facts-figures-2008 Accessed: February 18, 2012
11. R. Labianca, M.A. Pessi, G. Zamparelli Treatment of colorectal cancer Current guidelines and future prospects for drug therapy Drugs 53 1997 593 607
12. B.A. Magnuson, R.V. Raju, T.N. Moyana Increased N-myristoyltransferase activity observed in rat and human colonic tumors J Natl Cancer Inst 87 1995 1630 1635
13. S.F. Altschul, T.L. Madden, A.A. Schffer Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucleic Acids Res 25 1997 3389 3402
14. H. Schgger, G. von Jagow Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa Anal Biochem 166 1987 368 379
15. Q.J. He, B. Yang, Y.J. Lou Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo Asian J Androl 7 2005 389 393
16. H.L. Xu, Y. Inagaki, Y. Seyama Effect of benzyl-N-acetyl-α- galactosaminide on KL-6 mucin expression and invasive properties of a human pancreatic carcinoma cell line Drugs Discov Ther 2 2008 282 285
17. S.X. Cui, X.J. Qu, Y.Y. Xie Curcumin inhibits telomerase activity in human cancer cell lines Int J Mol Med 18 2006 227 231
18. C. Riccardi, I. Nicoletti Analysis of apoptosis by propidium iodide staining and flow cytometry Nat Protoc 1 2006 1458 1461
19. M.S. Butler The role of natural product chemistry in drug discovery J Nat Prod 67 2004 2141 2153
20. D.J. Newman, G.M. Cragg Natural products as sources of new drugs over the last 25 years J Nat Prod 70 2007 461 477
21. S. Grabley, R. Thiericke Bioactive agents from natural sources: trends in discovery and application Adv Biochem Eng/Biotechnol 64 1999 101 154
22. M.H. Munro, J.W. Blunt, E.J. Dumdei The discovery and development of marine compounds with pharmaceutical potential J Biotechnol 70 1999 15 25
23. D.J. Faulkner Highlights of marine natural products chemistry (1972-1999) Nat Prod Rep 17 2000 1 6
24. D.J. Newman, G.M. Cragg Marine natural products and related compounds in clinical and advanced preclinical trials J Nat Prod 67 2004 1216 1238
25. M.D. Lebar, J.L. Heimbegner, B.J. Baker Cold-water marine natural products Nat Prod Rep 24 2007 774 797
26. M. Shoyab, V.L. McDonald, C. Byles Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins Proc Natl Acad Sci U S A 87 1990 7912 7916