A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3′,5′-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A

Bioorganic Chemistry

Volumn 36, Issue 3, 2008, Pages 141-147

  Hung, Su H ^a   Liu, Andy H ^a   Pixley, Robin A ^a   Francis, Penelope ^a   Williams, LaTeeka D ^a   Matsko, Christopher M ^a   Barnes, Karine D ^a   Sivendran, Sharmila ^b   Colman, Roberta F ^b   Colman, Robert W ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

Affinity label; Human platelets; PDE3A; Phosphodiesterase; Rp cGMPS BDB

Indexed keywords

CYCLIC AMP PHOSPHODIESTERASE; CYCLIC GMP DERIVATIVE; GUANOSINE 3',5' (4 BROMO 2,3 DIOXOBUTYL)MONOPHOSPHOROTHIOATE; PHOSPHODIESTERASE III;

AFFINITY LABELING; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; THROMBOCYTE; WESTERN BLOTTING;

AFFINITY LABELS; BINDING SITES; BLOOD PLATELETS; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; ENZYME INHIBITORS; HUMANS; PROTEIN BINDING;

EID: 43249127456     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2008.02.006     Document Type: Article

References (32)

1. Colman R.F. Lett. Drug Des. Discov. 3 (2006) 462-480
2. Conti M., and Beavo J.A. Annu. Rev. Biochem. 76 (2007) 481-511
3. Bender A.T., and Beavo J.A. Pharmacol. Rev. 58 (2006) 488-520
4. Omori K., and Kotera. Circ. Res. 100 (2007) 309-327
5. Ke H., and Wang H. Curr. Top. Med. Chem. 7 (2007) 391-403
6. Cheung P.P., Xu H., McLaughlin M.M., Ghazaleh F.A., Livi G.P., and Colman R.W. Blood 88 (1996) 1321-1329
7. Meacci E., Taira M., Moos Jr. M., Smith C.J., Movsesian M.A., Degerman E., Belfrage P., and Manganiello V. Proc. Natl. Acad. Sci. USA 89 (1992) 3721-3725
8. Zhang W., and Colman R.W. Blood 95 (2000) 3380-3386
9. Zhang W., Ke H., Tretiakova A.P., Jameson B., and Colman R.W. Protein Sci. 10 (2001) 1481-1489
10. Hung S.H., Zhang W., Pixley R.A., Jameson B.A., Huang Y.C., Colman R.F., and Colman R.W. J. Biol. Chem. 281 (2006) 29236-29244
11. Ozturk D.H., Park I., and Colman R.F. Biochemistry 31 (1992) 10544-10555
12. Vollmer S.H., Walner M.B., Tarbell K.V., and Colman R.F. J. Biol. Chem. 269 (1994) 8082-8090
13. Hung S.H., Madhusoodanan K.S., Boyd R.L., Baldwin J.L., Colman R.F., and Colman R.W. Biochemistry 41 (2002) 2962-2969
14. Eckstein F., and Goody R.S. Biochemistry 15 (1976) 1685-1691
15. Jaffe E.K., and Cohn M. Biochemistry 17 (1978) 652-657
16. Connolly B.A., and Eckstein F. Biochemistry 21 (1982) 6158-6167
17. Kitz R., and Wilson I.B. J. Biol. Chem. 237 (1962) 3245-3249
18. Colman R.F. (1990), Academic Press, New York
19. Batra S.P., and Colman R.F. Biochemistry 25 (1986) 3508-3515
20. Mseeh F., Colman R.F., and Colman R.W. Thromb. Res. 98 (2000) 395-401
21. Grant P.G., DeCamp D.L., Bailey J.M., Colman R.W., and Colman R.F. Biochemistry 29 (1990) 887-894
22. Omburo G.A., Torphy T.J., Scott G., Jacobitz S., Colman R.F., and Colman R.W. Blood 89 (1997) 1019-1026
23. Lee T.T., Worby C., Dixon J.E., and Colman R.F. J. Biol. Chem. 272 (1997) 458-465
24. Lee T.T., Worby C., Bao Z.Q., Dixon J.E., and Colman R.F. Biochemistry 37 (1998) 8481-8489
25. Batra S.P., Lark R.H., and Colman R.F. Arch. Biochem. Biophys. 270 (1989) 277-285
26. DeCamp D.L., and Colman R.F. J. Biol. Chem. 264 (1989) 8430-8441
27. Huang Y.C., and Colman R.F. J. Biol. Chem. 264 (1989) 12208-12214
28. Bzymek K.P., and Colman R.F. Biochemistry 46 (2007) 5391-5397
29. Wrzeszczynski K.O., and Colman R.F. Biochemistry 33 (1994) 11544-11553
30. Butt E., Pohler D., Genieser H.G., Huggins J.P., and Bucher B. Br. J. Pharmacol. 116 (1995) 3110-3116
31. Wang X., and Pielak G.J. J. Mol. Biol. 221 (1991) 97-105
32. Zhang W., Ke H., and Colman R.W. Mol. Pharmacol. 62 (2002) 514-520