Novel oxysterols activate the Hedgehog pathway and induce osteogenesis

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5893-5897

  Stappenbeck, Frank ^a,b   Xiao, Wei ^a   Epperson, Matt ^a   Riley, Mariko ^a   Priest, Aaron ^a   Huang, Danwen ^a   Nguyen, Khanhlinh ^b   Jung, Michael E ^b   Scott Thies, R ^a   Farouz, Francine ^a  

^a Fate Therapeutics   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone formation; Deuterium incorporation; Hedgehog signaling; Oxysterols; Spinal fusion; Structure activity relationship

Indexed keywords

OSTEOCALCIN; OXYSTEROL; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; NONHUMAN; OSSIFICATION; RAT; SPINE FUSION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICROSOMES, LIVER; MOLECULAR CONFORMATION; OSTEOBLASTS; OSTEOGENESIS; RATS; SPINAL FUSION; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

ERINACEIDAE; RATTUS;

EID: 84865480185     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.073     Document Type: Article

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