Stiripentol: An example of antiepileptic drug development in childhood epilepsies

European Journal of Paediatric Neurology

Volumn 16, Issue SUPPL. 1, 2012, Pages

  Nabbout, Rima ^a   Chiron, Catherine ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Antiepileptic; Clobazam; GABAA receptor; Norclobazam; Stiripentol

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; DIAZEPAM; ETIRACETAM; LAMOTRIGINE; NORCLOBAZAM; PHENOBARBITAL; PLACEBO; STIRIPENTOL; THIOPENTAL; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ANOREXIA; ANTICONVULSANT ACTIVITY; BEHAVIOR DISORDER; BENIGN CHILDHOOD EPILEPSY; DROWSINESS; DRUG EFFICACY; DRUG HYDROXYLATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; ENZYME INHIBITION; EPILEPTIC STATE; HUMAN; KETOGENIC DIET; MUSCLE HYPOTONIA; NEUTROPENIA; NONHUMAN; PHARMACODYNAMICS; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SIDE EFFECT; SLEEP DISORDER; TONIC CLONIC SEIZURE; WEIGHT REDUCTION;

ANTICONVULSANTS; BENZODIAZEPINES; CHILD; CYTOCHROME P-450 ENZYME SYSTEM; DIOXOLANES; EPILEPSY; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84865462085     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2012.04.009     Document Type: Review

References (28)

1. J. Perez, C. Chiron, and C. Musial Stiripentol: efficacy and tolerability in children with epilepsy Epilepsia 40 1999 1618 1626
2. C. Chiron, M.C. Marchand, and A. Tran Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group Lancet 356 2000 1638 1642
3. B. Kassai, C. Chiron, and S. Augier Severe myoclonic epilepsy in infancy: a systematic review and a meta-analysis of individual patient data Epilepsia 49 2008 343 348
4. T.N. Thanh, C. Chiron, and G. Dellatolas Efficacité et tolérance long terme du stiripentol dans le traitement de l'épilepsie myoclonique sévre du nourrisson (syndrome de Dravet) Arch Pediatr 9 2002 1120 1127
5. C. Dravet, and M. Bureau Severe myoclonic epilepsy in infancy (Dravet syndrome) Epilepsy J. Engel Jr. T.A. Pedley, A comprehensive textbook 2008 Lippincott Williams & Wilkins Philadelphia 2337
6. T. Tanabe, Y. Awaya, and T. Matsuishi Management of and prophylaxis against status epilepticus in children with severe myoclonic epilepsy in infancy (SMEI; Dravet syndrome) - A nationwide questionnaire survey in Japan Brain Dev 30 2008 629 635
7. R. Guerrini, C. Dravet, and P. Genton Lamotrigine and seizure aggravation in severe myoclonic epilepsy Epilepsia 39 1998 508 512
8. M. Chipaux, N. Villeneuve, and P. Sabouraud Unusual consequences of status epilepticus in Dravet syndrome Seizure 19 2010 190 194
9. M. Nieto-Barrera, R. Candau, M. Nieto-Jimenez, A. Correa, and L.R. del Portal Topiramate in the treatment of severe myoclonic epilepsy in infancy Seizure 9 2000 590 594
10. G. Coppola, G. Capovilla, and A. Montagnini Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial Epilepsy Res 49 2002 45 48
11. J. Kroll-Seger, P. Portilla, O. Dulac, and C. Chiron Topiramate in the treatment of highly refractory patients with dravet syndrome Neuropediatrics 37 2006 325 329
12. P. Striano, G. Coppola, and M. Pezella An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy Neurology 69 2007 250 254
13. S. Chhun, P. Troude, and N. Villeneuve A prospective open-labeled trial with levetiracetam in pediatric epilepsy syndromes: continuous spikes and waves during sleep is definitely a target Seizure 20 2011 320 325
14. R. Nabbout, C. Copioli, and M. Chipaux Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: a prospective pilot study Epilepsia 52 2011 e54-7
15. P.P. Quilichini, C. Chiron, Y. Ben-Ari, and H. Gozlan Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-receptor channels Epilepsia 47 2006 704 716
16. J.L. Fisher The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator Neuropharmacology 56 2009 190 197
17. D.J. Laurie, W. Wisden, and P.H. Seeburg The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development J Neurosci 12 1992 4151 4172
18. J.L. Fisher Interactions between modulators of the GABA(A) receptor: stiripentol and benzodiazepines Eur J Pharmacol 654 2011 160 165
19. D.K. Grosenbaugh, and D.D. Mott Stiripentol is anticonvulsant in benzodiazepine-resistant status epilepticus, 3rd London Innsbruck Colloquium on acute seizures and status epilepticus Oxford, United Kingdom April 7-9, 2011
20. A. Tran, E. Rey, and G. Pons Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivoinhibition constants Clin Pharmacol Ther 62 1997 490 504
21. N. Cazali, A. Tran, and J.M. Treluyer Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human Br J Clin Pharmacol 56 2003 526 536
22. C. Giraud, J.M. Treluyer, and E. Rey In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism Drug Metab Dispos 34 2006 608 611
23. S.I. Hung, W.H. Chung, and Z.S. Liu Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese Pharmacogenomics 11 2010 349 356
24. P. Chen, J.J. Lin, and C.S. Lu Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan N Engl J Med 364 2011 1126 1133
25. C. Depondt, P. Godard, and R.S. Espel A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity Eur J Neurol 18 2011 1159 1164
26. Z. Desta, X. Zhao, J.G. Shin, and D.A. Flockhart Clinical significance of the cytochrome P450 2C19 genetic polymorphism Clin Pharmacokinet 41 2002 913 958
27. K. Kosaki, K. Tamura, and R. Sato A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam Brain Dev 26 2004 530 534
28. Y. Inoue, Y. Ohtsuka, and H. Oguni Stiripentol open study in Japanese patients with Dravet syndrome Epilepsia 50 2009 2362 2368