Evidence that hydroxysafflor yellow A protects the heart against ischaemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 2, 2008, Pages 211-216

  Liu, Yi Na ^a   Zhou, Zhong Min ^b   Chen, Peng ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Heart; Hydroxysafflor yellow A; Mitochondrial permeability transition pore; Nitric oxide; Reperfusion injury

Indexed keywords

ATRACTYLOSIDE; CALCIUM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYSAFFLOR YELLOW A; LACTATE DEHYDROGENASE; N(G) NITROARGININE METHYL ESTER; SAFFLOWER EXTRACT; TETRAMETHYLRHODAMINE ETHYL ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLUORESCENCE; HEART DEPOLARIZATION; HEART INFARCTION SIZE; HEART INJURY; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; ISOLATED HEART; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; RAT; SAFFLOWER; SWELLING; WESTERN BLOTTING;

ANIMALS; ATRACTYLOSIDE; CARDIOVASCULAR AGENTS; CELL SURVIVAL; CHALCONE; ENZYME INHIBITORS; L-LACTATE DEHYDROGENASE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PERFUSION; PHOSPHORYLATION; QUINONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 38149125409     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04814.x     Document Type: Article

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