Use of partition coefficients in flow-limited physiologically-based pharmacokinetic modeling

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 39, Issue 4, 2012, Pages 313-327

  Thompson, Matthew D ^a   Beard, Daniel A ^a   Wu, Fan ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CFD RESEARCH CORPORATION   (United States)

Author keywords

Biophysical; Compartmental modeling; Cotinine; Diazepam; Flow limited; Partition coefficient; Permeability limited; Physiologically based pharmacokinetics; Well stirred tank

Indexed keywords

COTININE; DIAZEPAM;

ACCURACY; ARTICLE; BIOPHYSICS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG TISSUE LEVEL; FLOW LIMITED PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL; LIVER METABOLISM; MATHEMATICAL MODEL; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PREDICTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SIMULATION; STIRRED REACTOR; THEORETICAL MODEL; TISSUE BLOOD FLOW;

ANIMALS; AREA UNDER CURVE; COTININE; DIAZEPAM; HUMANS; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACOKINETICS; RATS; TISSUE DISTRIBUTION;

EID: 84865455552     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-012-9252-6     Document Type: Article

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