Development of appropriate equations for physiologically based pharmacokinetic modeling of permeability-limited and flow-limited transport

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 38, Issue 4, 2011, Pages 405-421

  Thompson, Matthew D ^a   Beard, Daniel A ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Compartmental modeling; Flow limited; Permeability limited; Physiologically based pharmacokinetics; Singular perturbation; Well stirred tank

Indexed keywords

DRUG; TOXIN;

ARTICLE; BIOPHYSICS; CARDIOVASCULAR SYSTEM; COMPARTMENT MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CONCENTRATION; DRUG PENETRATION; DRUG TRANSPORT; EXTRAVASCULAR SPACE; FLOW KINETICS; IN VIVO STUDY; MATHEMATICAL MODEL; METABOLITE; NUTRIENT; PHARMACOKINETICS; PRIORITY JOURNAL; TISSUE; TISSUE COMPARTMENT MODEL;

BIOLOGICAL TRANSPORT; HUMANS; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACOKINETICS; REGIONAL BLOOD FLOW; TISSUE DISTRIBUTION;

EID: 80052589785     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-011-9200-x     Document Type: Article

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