5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 9, 2012, Pages 4845-4855

  Kwong, Thomas ^a,b   Zelyas, Nathan J ^a   Cai, Hui ^a,c   Tahlan, Kapil ^a,d   Wong, Annie ^a   Jensen, Susan E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Pharmaceutical Product Development   (United States)

^d MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5S CLAVAM; CLAVULANIC ACID; PHOSPHATE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA DETERMINATION; DNA SEQUENCE; GENE CLUSTER; GENE LOCATION; GENE MUTATION; GENETIC TRANSCRIPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SITE DIRECTED MUTAGENESIS; STREPTOMYCES CLAVULIGERUS;

AMINO ACID SEQUENCE; BETA-LACTAMASES; CLAVULANIC ACID; CLAVULANIC ACIDS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENES, REGULATOR; GENETIC COMPLEMENTATION TEST; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTATION; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOMYCES; TRANSCRIPTIONAL ACTIVATION;

EID: 84865428563     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01090-12     Document Type: Article

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