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Volumn 235, Issue 2, 2012, Pages 210-217

Age-related memory decline is associated with vascular and microglial degeneration in aged rats

Author keywords

Glial degeneration; Hippocampus; Memory; Normal aging; Vascular degeneration and VEGF expression

Indexed keywords

DOPAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; VASCULOTROPIN;

EID: 84865426876     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.08.002     Document Type: Article
Times cited : (22)

References (49)
  • 1
    • 0037936789 scopus 로고    scopus 로고
    • Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
    • Rosenzweig E.S., Barnes C.A. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Progress in Neurobiology 2003, 69:143-179.
    • (2003) Progress in Neurobiology , vol.69 , pp. 143-179
    • Rosenzweig, E.S.1    Barnes, C.A.2
  • 2
    • 20444369864 scopus 로고    scopus 로고
    • The aging hippocampus: navigating between rat and human experiments
    • Driscoll I., Sutherland R.J. The aging hippocampus: navigating between rat and human experiments. Reviews in the Neurosciences 2005, 16:87-121.
    • (2005) Reviews in the Neurosciences , vol.16 , pp. 87-121
    • Driscoll, I.1    Sutherland, R.J.2
  • 3
    • 0036839248 scopus 로고    scopus 로고
    • Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits
    • Rapp P.R., Deroche P.S., Mao Y., Burwell R.D. Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits. Cerebral Cortex 2002, 12:1171-1179.
    • (2002) Cerebral Cortex , vol.12 , pp. 1171-1179
    • Rapp, P.R.1    Deroche, P.S.2    Mao, Y.3    Burwell, R.D.4
  • 5
    • 0034279244 scopus 로고    scopus 로고
    • Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats
    • Smith T.D., Adams M.M., Gallagher M., Morrison J.H., Rapp P.R. Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. Journal of Neuroscience 2000, 20:6587-6593.
    • (2000) Journal of Neuroscience , vol.20 , pp. 6587-6593
    • Smith, T.D.1    Adams, M.M.2    Gallagher, M.3    Morrison, J.H.4    Rapp, P.R.5
  • 6
    • 70349425672 scopus 로고    scopus 로고
    • Astrocytic dysfunction: insights on the role in neurodegeneration
    • Rossi D., Volterra A. Astrocytic dysfunction: insights on the role in neurodegeneration. Brain Research Bulletin 2009, 80:224-232.
    • (2009) Brain Research Bulletin , vol.80 , pp. 224-232
    • Rossi, D.1    Volterra, A.2
  • 7
    • 58149335393 scopus 로고    scopus 로고
    • Microglia in normal condition and pathology
    • Pivneva T.A. Microglia in normal condition and pathology. Fiziologicheskii Zhurnal 2008, 54:81-89.
    • (2008) Fiziologicheskii Zhurnal , vol.54 , pp. 81-89
    • Pivneva, T.A.1
  • 8
    • 77952423623 scopus 로고    scopus 로고
    • The contribution of astrocyte signalling to neurovascular coupling
    • Carmignoto G., Gomez-Gonzalo M. The contribution of astrocyte signalling to neurovascular coupling. Brain Research Reviews 2010, 63:138-148.
    • (2010) Brain Research Reviews , vol.63 , pp. 138-148
    • Carmignoto, G.1    Gomez-Gonzalo, M.2
  • 10
    • 59649127325 scopus 로고    scopus 로고
    • Intra-hippocampal administration of the VEGF receptor blocker PTK787/ZK222584 impairs long-term memory
    • Pati S., Orsi S.A., Moore A.N., Dash P.K. Intra-hippocampal administration of the VEGF receptor blocker PTK787/ZK222584 impairs long-term memory. Brain Research 2009, 1256:85-91.
    • (2009) Brain Research , vol.1256 , pp. 85-91
    • Pati, S.1    Orsi, S.A.2    Moore, A.N.3    Dash, P.K.4
  • 11
    • 79961175318 scopus 로고    scopus 로고
    • The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
    • Quaegebeur A., Lange C., Carmeliet P. The neurovascular link in health and disease: molecular mechanisms and therapeutic implications. Neuron 2011, 71:406-424.
    • (2011) Neuron , vol.71 , pp. 406-424
    • Quaegebeur, A.1    Lange, C.2    Carmeliet, P.3
  • 12
    • 2542427736 scopus 로고    scopus 로고
    • Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain
    • Tayebati S.K., Di Tullio M.A., Amenta F. Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain. Clinical and Experimental Hypertension 2004, 26:363-373.
    • (2004) Clinical and Experimental Hypertension , vol.26 , pp. 363-373
    • Tayebati, S.K.1    Di Tullio, M.A.2    Amenta, F.3
  • 13
    • 80051499935 scopus 로고    scopus 로고
    • Dopamine and vascular dynamics control: present status and future perspectives
    • Tayebati S.K., Lokhandwala M.F., Amenta F. Dopamine and vascular dynamics control: present status and future perspectives. Current Neurovascualar Research 2011, 8:246-257.
    • (2011) Current Neurovascualar Research , vol.8 , pp. 246-257
    • Tayebati, S.K.1    Lokhandwala, M.F.2    Amenta, F.3
  • 15
    • 0032211352 scopus 로고    scopus 로고
    • VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS
    • Krum J.M., Rosenstein J.M. VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS. Experimental Neurology 1998, 154:57-65.
    • (1998) Experimental Neurology , vol.154 , pp. 57-65
    • Krum, J.M.1    Rosenstein, J.M.2
  • 16
    • 0033638730 scopus 로고    scopus 로고
    • Functions of the VEGF/VEGF receptor system in the vascular system
    • Breier G. Functions of the VEGF/VEGF receptor system in the vascular system. Seminars in Thrombosis and Hemostasis 2000, 26:553-559.
    • (2000) Seminars in Thrombosis and Hemostasis , vol.26 , pp. 553-559
    • Breier, G.1
  • 17
    • 0037716760 scopus 로고    scopus 로고
    • Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF in brain repair
    • Krum J.M., Khaibullina A. Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF in brain repair. Experimental Neurology 2003, 181:241-257.
    • (2003) Experimental Neurology , vol.181 , pp. 241-257
    • Krum, J.M.1    Khaibullina, A.2
  • 18
    • 59249107409 scopus 로고    scopus 로고
    • Decreased vascular repair and neovascularization with ageing: mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1
    • Hoenig M.R., Bianchi C., Rosenzweig A., Sellke F.W. Decreased vascular repair and neovascularization with ageing: mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1. Current Molecular Medicine 2008, 8:754-767.
    • (2008) Current Molecular Medicine , vol.8 , pp. 754-767
    • Hoenig, M.R.1    Bianchi, C.2    Rosenzweig, A.3    Sellke, F.W.4
  • 19
    • 2342667384 scopus 로고    scopus 로고
    • New roles for VEGF in nervous tissue-beyond blood vessels
    • Rosenstein J.M., Krum J.M. New roles for VEGF in nervous tissue-beyond blood vessels. Experimental Neurology 2004, 187:246-253.
    • (2004) Experimental Neurology , vol.187 , pp. 246-253
    • Rosenstein, J.M.1    Krum, J.M.2
  • 21
    • 77952321367 scopus 로고    scopus 로고
    • NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat
    • Guan J., Zhang R., Dale-Gandar L., Hodgkinson S., Vickers M. NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat. Behavioural Brain Research 2010, 210:7.
    • (2010) Behavioural Brain Research , vol.210 , pp. 7
    • Guan, J.1    Zhang, R.2    Dale-Gandar, L.3    Hodgkinson, S.4    Vickers, M.5
  • 22
    • 0032932972 scopus 로고    scopus 로고
    • The effects of the N-terminal tripeptide of insulin-like growth factor- 1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats
    • Guan J., Waldvogel H.J., Faull R.L., Gluckman P.D., Williams C.E. The effects of the N-terminal tripeptide of insulin-like growth factor- 1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats. Neuroscience 1999, 89:649-659.
    • (1999) Neuroscience , vol.89 , pp. 649-659
    • Guan, J.1    Waldvogel, H.J.2    Faull, R.L.3    Gluckman, P.D.4    Williams, C.E.5
  • 23
    • 34548324511 scopus 로고    scopus 로고
    • Delayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal rat
    • Svedin P., Guan J., Mathai S., Zhang R., Wang X., Gustavsson M., et al. Delayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal rat. Developmental Neuroscience 2007, 29:393-402.
    • (2007) Developmental Neuroscience , vol.29 , pp. 393-402
    • Svedin, P.1    Guan, J.2    Mathai, S.3    Zhang, R.4    Wang, X.5    Gustavsson, M.6
  • 24
    • 62349097195 scopus 로고    scopus 로고
    • Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats
    • Shapira S., Mathai S., Zhang R., Guan J. Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats. Neuroscience Letters 2009, 454:53-57.
    • (2009) Neuroscience Letters , vol.454 , pp. 53-57
    • Shapira, S.1    Mathai, S.2    Zhang, R.3    Guan, J.4
  • 25
    • 34948892049 scopus 로고    scopus 로고
    • Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor funcion following hypoxia-ischemia in adult rats
    • Guan J., Mathai S., Harris A.P., Wen J.Y., Zhang R., Brimble M.A., et al. Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor funcion following hypoxia-ischemia in adult rats. Neuropharmacology 2007, 53:749-762.
    • (2007) Neuropharmacology , vol.53 , pp. 749-762
    • Guan, J.1    Mathai, S.2    Harris, A.P.3    Wen, J.Y.4    Zhang, R.5    Brimble, M.A.6
  • 26
    • 14944364095 scopus 로고    scopus 로고
    • Immunocytochemical stereological analysis of GABA(B) receptor subunit expression in the rat vestibular nucleus following unilateral vestibular deafferentation
    • Zhang R., Ashton J., Horii A., Darlington C.L., Smith P.F. Immunocytochemical stereological analysis of GABA(B) receptor subunit expression in the rat vestibular nucleus following unilateral vestibular deafferentation. Brain Research 2005, 1037:107-113.
    • (2005) Brain Research , vol.1037 , pp. 107-113
    • Zhang, R.1    Ashton, J.2    Horii, A.3    Darlington, C.L.4    Smith, P.F.5
  • 27
    • 0036979159 scopus 로고    scopus 로고
    • Neurons, glia, and plasticity in normal brain aging
    • Finch C.E. Neurons, glia, and plasticity in normal brain aging. Advance in Gerontology 2002, 10:35-39.
    • (2002) Advance in Gerontology , vol.10 , pp. 35-39
    • Finch, C.E.1
  • 28
    • 77649335893 scopus 로고    scopus 로고
    • Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues
    • Backman L., Lindenberger U., Li S.C., Nyberg L. Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues. Neuroscience and Biobehavioral Reviews 2009, 34:670-677.
    • (2009) Neuroscience and Biobehavioral Reviews , vol.34 , pp. 670-677
    • Backman, L.1    Lindenberger, U.2    Li, S.C.3    Nyberg, L.4
  • 30
    • 80052013736 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia
    • Ohlin K.E., Francardo V., Lindgren H.S., Sillivan S.E., O'Sullivan S.S., Luksik A.S., et al. Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia. Brain 2011, 134:2339-2357.
    • (2011) Brain , vol.134 , pp. 2339-2357
    • Ohlin, K.E.1    Francardo, V.2    Lindgren, H.S.3    Sillivan, S.E.4    O'Sullivan, S.S.5    Luksik, A.S.6
  • 31
    • 82655184092 scopus 로고    scopus 로고
    • Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons
    • Threlfell S., Cragg S.J. Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons. Frontiers in Systems Neuroscience 2011, 5:11.
    • (2011) Frontiers in Systems Neuroscience , vol.5 , pp. 11
    • Threlfell, S.1    Cragg, S.J.2
  • 33
    • 44549083361 scopus 로고    scopus 로고
    • Age-related changes of NGF, BDNF, parvalbumin and neuronal nitric oxide synthase immunoreactivity in the mouse hippocampal CA1 sector
    • Hayakawa N., Abe M., Eto R., Kato H., Araki T. Age-related changes of NGF, BDNF, parvalbumin and neuronal nitric oxide synthase immunoreactivity in the mouse hippocampal CA1 sector. Metabolic Brain Disease 2008, 23:199-211.
    • (2008) Metabolic Brain Disease , vol.23 , pp. 199-211
    • Hayakawa, N.1    Abe, M.2    Eto, R.3    Kato, H.4    Araki, T.5
  • 35
    • 51349095669 scopus 로고    scopus 로고
    • Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity
    • Lopes K.O., Sparks D.L., Streit W.J., Conde J.R. Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity. Glia 2008, 56:1048-1060.
    • (2008) Glia , vol.56 , pp. 1048-1060
    • Lopes, K.O.1    Sparks, D.L.2    Streit, W.J.3    Conde, J.R.4
  • 36
    • 80053467489 scopus 로고    scopus 로고
    • Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases
    • Aliev G., Li Y., Palacios H.H., Obrenovich M.E. Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases. Recent Patents on Cardiovascular Drug Discovery 2011, 6:222-241.
    • (2011) Recent Patents on Cardiovascular Drug Discovery , vol.6 , pp. 222-241
    • Aliev, G.1    Li, Y.2    Palacios, H.H.3    Obrenovich, M.E.4
  • 37
    • 0032584931 scopus 로고    scopus 로고
    • Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury
    • Beilharz E.J., Russo V.C., Butler G., Baker N.L., Connor B., Sirimanne E.S., et al. Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury. Brain Research. Molecular Brain Research 1998, 59:119-134.
    • (1998) Brain Research. Molecular Brain Research , vol.59 , pp. 119-134
    • Beilharz, E.J.1    Russo, V.C.2    Butler, G.3    Baker, N.L.4    Connor, B.5    Sirimanne, E.S.6
  • 38
    • 0038119611 scopus 로고    scopus 로고
    • Insulin-like Growth Factor (IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep
    • Cao Y., Gunn A.J., Bennet L., Wu D., George S., Gluckman P.D., et al. Insulin-like Growth Factor (IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep. Journal of Cerebral Blood Flow and Metabolism 2003, 23:739-747.
    • (2003) Journal of Cerebral Blood Flow and Metabolism , vol.23 , pp. 739-747
    • Cao, Y.1    Gunn, A.J.2    Bennet, L.3    Wu, D.4    George, S.5    Gluckman, P.D.6
  • 40
    • 0029161762 scopus 로고
    • Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: a cytological, morphometric, and immunocytochemical study
    • Berciano M.T., Andres M.A., Calle E., Lafarga M. Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: a cytological, morphometric, and immunocytochemical study. Anatomical Record 1995, 243:129-144.
    • (1995) Anatomical Record , vol.243 , pp. 129-144
    • Berciano, M.T.1    Andres, M.A.2    Calle, E.3    Lafarga, M.4
  • 41
    • 0032191725 scopus 로고    scopus 로고
    • Astrocyte changes in aging cerebral cortex and hippocampus: a quantitative immunohistochemical study
    • Amenta F., Bronzetti E., Sabbatini M., Vega J.A. Astrocyte changes in aging cerebral cortex and hippocampus: a quantitative immunohistochemical study. Microscopy Research and Technique 1998, 43:29-33.
    • (1998) Microscopy Research and Technique , vol.43 , pp. 29-33
    • Amenta, F.1    Bronzetti, E.2    Sabbatini, M.3    Vega, J.A.4
  • 44
    • 42449147458 scopus 로고    scopus 로고
    • Classifying late-onset dementia with MRI: is arteriosclerotic brain degeneration the most common cause of Alzheimer's syndrome?
    • Henry-Feugeas M.C., Onen F., Claeys E.S. Classifying late-onset dementia with MRI: is arteriosclerotic brain degeneration the most common cause of Alzheimer's syndrome?. Clinical Interventions in Aging 2008, 3:187-199.
    • (2008) Clinical Interventions in Aging , vol.3 , pp. 187-199
    • Henry-Feugeas, M.C.1    Onen, F.2    Claeys, E.S.3
  • 45
    • 68849084613 scopus 로고    scopus 로고
    • Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor
    • Shibuya M. Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor. FEBS Journal 2009, 276:4636-4643.
    • (2009) FEBS Journal , vol.276 , pp. 4636-4643
    • Shibuya, M.1
  • 46
    • 34247174374 scopus 로고    scopus 로고
    • Age-related changes of astorocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sector
    • Hayakawa N., Kato H., Araki T. Age-related changes of astorocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sector. Mechanisms of Ageing and Development 2007, 128:311-316.
    • (2007) Mechanisms of Ageing and Development , vol.128 , pp. 311-316
    • Hayakawa, N.1    Kato, H.2    Araki, T.3
  • 47
    • 36048947606 scopus 로고    scopus 로고
    • Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
    • Hattiangady B., Shetty A.K. Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiology of Aging 2008, 29:129-147.
    • (2008) Neurobiology of Aging , vol.29 , pp. 129-147
    • Hattiangady, B.1    Shetty, A.K.2
  • 48
    • 54849428907 scopus 로고    scopus 로고
    • Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2
    • Zhu M., Gu F., Shi J., Hu J., Hu Y., Zhao Z. Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2. Free Radical Biology and Medicine 2008, 45:1493-1499.
    • (2008) Free Radical Biology and Medicine , vol.45 , pp. 1493-1499
    • Zhu, M.1    Gu, F.2    Shi, J.3    Hu, J.4    Hu, Y.5    Zhao, Z.6
  • 49
    • 34548801253 scopus 로고    scopus 로고
    • Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain
    • Mora F., Segovia G., Del Arco A. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Research Reviews 2007.
    • (2007) Brain Research Reviews
    • Mora, F.1    Segovia, G.2    Del Arco, A.3


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