Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats

Neuroscience Letters

Volumn 454, Issue 1, 2009, Pages 53-57

  Shapira, Shlomo ^a   Mathai, Sam ^a   Zhang, Rong ^a   Guan, Jian ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Aged rats; Delayed peripheral administration; Embolic brain injury; GPE; Neuroprotection

Indexed keywords

GLUCOSE; GLYCINE PROLINE GLUTAMATE; MICROSPHERE; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN DAMAGE; CONTROLLED STUDY; CORE TEMPERATURE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HEART RATE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTERNAL CAROTID ARTERY; MALE; NONHUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; RAT;

AGE FACTORS; ANIMALS; DRUG ADMINISTRATION SCHEDULE; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; INTRACRANIAL EMBOLISM; MALE; MICROSPHERES; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; RATS; REPERFUSION INJURY;

EID: 62349097195     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.03.003     Document Type: Article

References (27)

1. Auer R.N. Insulin, blood glucose levels, and ischemic brain damage. Neurology 51 (1998) S39-S43
2. Davis M., Mendelow A.D., Perry R.H., Chambers I.R., and James O.F. Experimental stroke and neuroprotection in the aging rat brain. Stroke 26 (1995) 1072-1078
3. Dias da Silva V.J., Montano N., Salgado H.C., and Fazan Junior R. Effects of long-term angiotensin converting enzyme inhibition on cardiovascular variability in aging rats. Auton. Neurosci. 124 (2006) 49-55
4. Djaiani G.N. Aortic arch atheroma: stroke reduction in cardiac surgical patients. Semin. Cardiothorac. Vasc. Anesth. 10 (2006) 143-157
5. Driscoll I., and Sutherland R.J. The aging hippocampus: navigating between rat and human experiments. Rev. Neurosci. 16 (2005) 87-121
6. Finch C.E. Neurons, glia, and plasticity in normal brain aging. Adv. Gerontol. 10 (2002) 35-39
7. Fiorelli M., Alperovitch A., Argentino C., Sacchetti M.L., Toni D., Sette G., Cavalletti C., Gori M.C., and Fieschi C. Prediction of long-term outcome in the early hours following acute ischemic stroke. Italian Acute Stroke Study Group. Arch. Neurol. 52 (1995) 250-255
8. Gladsrone D.J., Black S.E., and Hakim A.M. Toward wisdom from failure- Lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 33 (2002) 2123-2136
9. Guan J., Gunn A.J., Sirimanne E.S., Tuffin J., Gunning M.I., Clark R., and Gluckman P.D. The window of opportunity for neuronal rescue with insulin-like growth factor-1 after hypoxia-ischemia in rats is critically modulated by cerebral temperature during recovery. J. Cereb. Blood Flow Metab. 20 (2000) 513-519
10. Guan J., Thomas G.B., Lin H., Mathai S., Bachelor D.C., George S., and Gluckman P.D. Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats. Neuropharmacology 47 (2004) 892-903
11. Guan J., Waldvogel H.J., Faull R.L., Gluckman P.D., and Williams C.E. The effects of the N-terminal tripeptide of insulin-like growth factor-1. Glycine-proline-glutamate in different regions following hypoxic- ischemic brain injury in adult rats. Neuroscience 89 (1999) 649-659
12. Guan J., Williams C., Gunning M., Mallard C., and Gluckman P. The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats. J. Cereb. Blood Flow Metab. 13 (1993) 609-616
13. Gunn A.J., and Bennet L. Hypothermia in the management of hypoxic-ischemic encephalopathy. NeoReviews 3 (2002) e116-e122
14. Irigoyen M.C., Moreira E.D., Werner A., Ida F., Pires M.D., Cestari I.A., and Krieger E.M. Aging and baroreflex control of RSNA and heart rate in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 (2000) R1865-1871
15. Lees K.R. Management of acute stroke. Lancet Neurol. 1 (2002) 41-50
16. Leira R., Blanco M., Rodriguez-Yanez M., Flores J., and Garcia-Garcia J. Non-pharmacological neuroprotection: role of emergency stroke management. Cerebrovasc. Dis. 21 Suppl. 2 (2006) 89-98
17. Li L., Jiang Q., Zhang L., Ding G., Gang Zhang Z., Li Q., Ewing J.R., Lu M., Panda S., Ledbetter K.A., Whitton P.A., and Chopp M. Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke. Brain Res. 1132 (2007) 185-192
18. Mitchell J.J., Paiva M., Walker D.W., and Heaton M.B. BDNF and NGF afford in vitro neuroprotection against ethanol combined with acute ischemia and chronic hypoglycemia. Dev. Neurosci. 21 (1999) 68-75
19. Sabelhaus C.F., Schroder U.H., Breder J., Henrich-Noack P., and Reymann K.G. Neuroprotection against hypoxic/hypoglycaemic injury after the insult by the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine. Br. J. Pharmacol. 131 (2000) 655-658
20. Shapira S., Sapir M., and Wengier A. Aging has a complex effect on a rat model of ischemic stroke. Brain Res. 925 (2002) 148-158
21. Sutherland G.R., Dix G.A., and Auer R.N. Effect of age in rodent models of focal and forebrain ischemia. Stroke 27 (1996) 1663-1667 (discussion 1668)
22. Svedin P., Guan J., Mathai S., Zhang R., Wang X., Gustavsson M., Hagberg H., and Mallard C. Delayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal rat. Dev. Neurosci. 29 (2007) 393-402
23. Traystman R.J. Animal models of focal and global cerebral ischemia. ILAR J. 44 (2003) 85-95
24. Warlow C., Sudlow C., Dennis M., Wardlaw J., and Sandercock P. Stroke. Lancet 362 (2003) 1211-1224
25. Wu W.W., Oh M.M., and Disterhoft J.F. Age-related biophysical alterations of hippocampal pyramidal neurons: implications for learning and memory. Ageing Res. Rev. 1 (2002) 181-207
26. Yamamoto H., and Murphy L.J. Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: A further potential site of growth hormone regulation of IGF-I action. J. Endocrinol. 146 (1995) 141-148
27. Zhu C., Wang X., Xu F., Bahr B.A., Shibata M., Uchiyama Y., Hagberg H., and Blomgren K. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ. 12 (2005) 162-176