Deletion of cognate CD8 T cells by immature dendritic cells: A novel role for perforin, granzyme A, TREM-1, and TLR7

Blood

Volumn 120, Issue 8, 2012, Pages 1647-1657

  Zangi, Lior ^a   Klionsky, Yael Zlotnikov ^a   Yarimi, Liran ^a   Bachar Lustig, Esther ^a   Eidelstein, Yaki ^a   Shezen, Elias ^a   Hagin, David ^a   Ito, Yumi ^b   Takai, Toshiyuki ^b   Reich Zeliger, Shlomit ^a   Lask, Assaf ^a   Milstein, Oren ^a   Jung, Steffen ^a   Shinder, Vera ^a   Reisner, Yair ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; CD11B ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GRANZYME A; INTERLEUKIN 3; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NITRIC OXIDE; PERFORIN; TOLL LIKE RECEPTOR 7; TRANSFORMING GROWTH FACTOR BETA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

EID: 84865418252     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-02-410803     Document Type: Article

References (56)

1. Zehn D, Bevan MJ. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity. 2006;25(2):261-270. (Pubitemid 44224142)
2. Gallegos AM, Bevan MJ. Central tolerance: Good but imperfect. Immunol Rev. 2006;209:290.
3. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med. 2001;193(2):233-238. (Pubitemid 32524454)
4. Fu F, Li Y, Qian S, et al. Costimulatory moleculedeficient dendritic cell progenitors (MHC class II, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation. 1996;62(5):659-665. (Pubitemid 26313912)
5. Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH. Induction of interleukin 10-producing, nonproliferating CD4 T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med. 2000;192(9):1213-1222.
6. Lutz MB, Kukutsch NA, Menges M, Rossner S, Schuler G. Culture of bone marrow cells in GMCSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro. Eur J Immunol. 2000;30(4):1048-1052. (Pubitemid 30216220)
7. Tiao MM, Lu L, Tao R, Wang L, Fung JJ, Qian S. Prolongation of cardiac allograft survival by systemic administration of immature recipient dendritic cells deficient in NF-kappaB activity. Ann Surg. 2005;241(3):497-505. (Pubitemid 40299728)
8. Trinité B, Chauvin C, Peche H, Voisine C, Heslan M, Josien R. Immature CD4-CD103 rat dendritic cells induce rapid caspase-independent apoptosis-like cell death in various tumor and nontumor cells and phagocytose their victims. J Immunol. 2005;175(4):2408-2418.
9. Yu P, Xiong S, He Q, et al. Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts. Immunology. 2009;127(4):500-511.
10. Pêche H, Trinite B, Martinet B, Cuturi MC. Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am J Transplant. 2005;5(2):255-267. (Pubitemid 40179512)
11. Lutz MB, Suri RM, Niimi M, et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol. 2000;30(7):1813-1822. (Pubitemid 30456177)
12. Kim YS, Yang SH, Kang HG, et al. Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance. Int Immunol. 2006;18(12):1771-1777. (Pubitemid 44884039)
13. Lu L, Qian S, Hershberger PA, Rudert WA, Lynch DH, Thomson AW. Fas ligand (CD95L) and B7 expression on dendritic cells provide counterregulatory signals for T cell survival and proliferation. J Immunol. 1997;158(12):5676-5684. (Pubitemid 127483971)
14. Luckey U, Maurer M, Schmidt T, et al. T cell killing by tolerogenic dendritic cells protects mice from allergy. J Clin Invest. 2011;121(10):3860- 3871.
15. Süss G, Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med. 1996;183(4):1789-1796.
16. Waithman J, Allan RS, Kosaka H, et al. Skinderived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells. J Immunol. 2007;179(7):4535-4541.
17. Yu Y, Liu S, Wang W, et al. Involvement of tumour necrosis factor-α-related apoptosis-inducing ligand in enhanced cytotoxicity of lipopolysaccharidestimulated dendritic cells to activated T cells. Immunology. 2002;106(3):308-315. (Pubitemid 34748124)
18. Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: Cytokine modulation comes of age. Blood. 2006;108(5):1435-1440. (Pubitemid 44316106)
19. Depaolo RW, Tang F, Kim IY, et al. Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis. Cell Host Microbe. 2008;4(4):350-361.
20. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol. 2002;2(3):151-161. (Pubitemid 37336516)
21. Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, Gordon S. Macrophage receptors and immune recognition. Annu Rev Immunol. 2005;23:901-944. (Pubitemid 40563189)
22. Serbina NV, Jia T, Hohl TM, Pamer EG. Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol. 2008;26:421-452. (Pubitemid 351600381)
23. Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med. 1992;176(6):1693-1702.
24. Naik SH, Sathe P, Park HY, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol. 2007;8(11):1217-1226. (Pubitemid 350011760)
25. Naik SH, O'Keeffe M, Proietto A, Shortman HH, Wu L. CD8+, CD8-, and plasmacytoid dendritic cell generation in vitro using flt3 ligand. Methods Mol Biol. 2010;595:167-176.
26. Grubin CE, Kovats S, deRoos P, Rudensky AY. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class IIbound self-peptides. Immunity. 1997;7(2):197-208. (Pubitemid 27392012)
27. Sha WC, Nelson CA, Newberry RD, Kranzt DM, Russell JH, Loh DY. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 1988;335:271-274.
28. Kägi D, Ledermann B, Burki K, et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 1994;369(6475):31-37. (Pubitemid 24144352)
29. Lindquist RL, Shakhar G, Dudziak D, et al. Visualizing dendritic cell networks in vivo. Nat Immunol. 2004;5(12):1243-1250. (Pubitemid 41057739)
30. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature. 1988;336(6194):73-76. (Pubitemid 18262137)
31. Reich-Zeliger S, Gan J, Bachar-Lustig E, Reisner Y. Tolerance induction by veto CTLs in the TCR transgenic 2C mouse model. II. deletion of effector cells by fas-fas ligand apoptosis. J Immunol. 2004;173(11):6660-6666. (Pubitemid 39541050)
32. Mehta B, Schmidt-Wolf I, Weissman I, Negrin R. Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokineinduced CD3 CD56 killer cells. Blood. 1995;86(9):3493-3499.
33. Stephen TL, Harms F, Fabri M, et al. In vitro generation of murine myeloid dendritic cells from CD34-positive precursors. Cell Biol Int. 2009;33(7):778-784.
34. Rössner S, Voigtlander C, Wiethe C, Hanig J, Seifarth C, Lutz MB. Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Eur J Immunol. 2005;35(12):3533-3544. (Pubitemid 43025534)
35. Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med. 2007;204(6):1441-1451. (Pubitemid 46919881)
36. Bouchon A, Dietrich J, Colonna M. Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000;164(10):4991-4995. (Pubitemid 30305166)
37. Sharma MD, Baban B, Chandler P, et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature tregs via indoleamine 2, 3-dioxygenase. J Clin Invest. 2007;117(9):2570-2582. (Pubitemid 47494358)
38. Aiello S, Noris M, Piccinini G, et al. Thymic dendritic cells express inducible nitric oxide synthase and generate nitric oxide in response to self-and alloantigens. J Immunol. 2000;164(9):4649-4658. (Pubitemid 30238064)
39. Huang J, Tatsumi T, Pizzoferrato E, Vujanovic N, Storkus WJ. Nitric oxide sensitizes tumor cells to dendritic cell-mediated apoptosis, uptake, and cross-presentation. Cancer Res. 2005;65(18):8461-8470. (Pubitemid 41330614)
40. Shimamura H, Cumberland R, Hiroishi K, Watkins SC, Lotze MT, Baar J. Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide. J Immunother. 2002;25(3):226-234. (Pubitemid 34533312)
41. Fallarino F, Vacca C, Orabona C, et al. Functional expression of indoleamine 2, 3-dioxygenase by murine CD8 {alpha} dendritic cells. Int Immunol. 2002;14(1):65-68. (Pubitemid 34083398)
42. Shibaki A, Katz SI. Activation through CD40 ligation induces functional fas ligand expression by langerhans cells. Eur J Immunol. 2001;31(10):3006-3015. (Pubitemid 32994552)
43. Taieb J, Chaput N, Ménard C, et al. A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med. 2006;12(2):214-219. (Pubitemid 43214748)
44. Naik SH, Proietto AI, Wilson NS, et al. Cutting edge: Generation of splenic CD8 and CD8-dendritic cell equivalents in fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol. 2005;174(11):6592-6597. (Pubitemid 40705619)
45. Jahrsdörfer B, Vollmer A, Blackwell SE, et al. Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion. Blood. 2010;115(6):1156-1165.
46. Radsak MP, Salih HR, Rammensee HG, Schild H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol. 2004;172(8):4956-4963. (Pubitemid 38456421)
47. Fortin CF, Lesur O, Fulop T. Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Int Immunol. 2007;19(1):41-50. (Pubitemid 46017886)
48. Akira S, Yamamoto M, Takeda K. Role of adapters in toll-like receptor signalling. Biochem Soc Trans. 2003;31:637-642. (Pubitemid 36750746)
49. Colucci F, Caligiuri MA, Di Santo JP. What does it take to make a natural killer? Nat Rev Immunol. 2003;3(5):413-425. (Pubitemid 37323201)
50. Pillarisetty VG, Katz SC, Bleier JI, Shah AB, DeMatteo RP. Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-gamma via autocrine IL-12. J Immunol. 2005;174(5):2612-2618. (Pubitemid 40279674)
51. Chan CW, Crafton E, Fan HN, et al. Interferonproducing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med. 2006;12(2):207-213. (Pubitemid 43214747)
52. Blasius AL, Barchet W, Cella M, Colonna M. Development and function of murine B220 CD11c NK1. 1 cells identify them as a subset of NK cells. J Exp Med. 2007;204(11):2561-2568. (Pubitemid 350044782)
53. Vosshenrich CAJ, Lesjean-Pottier S, Hasan M, et al. CD11cloB220 interferon-producing killer dendritic cells are activated natural killer cells. J Exp Med. 2007;204(11):2569-2578. (Pubitemid 350044783)
54. Hackstein H, Morelli AE, Larregina AT, et al. Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells. J Immunol. 2001;166(12):7053-7062. (Pubitemid 32525574)
55. Hackstein H, Taner T, Zahorchak AF, et al. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood. 2003;101(11):4457-4463. (Pubitemid 36857814)
56. Hackstein H, Thomson AW. Dendritic cells: Emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol. 2004;4(1):24-35.