The role of haemoglobin mass on VO 2max following normobaric 'live high-train low' in endurance-trained athletes

British Journal of Sports Medicine

Volumn 46, Issue 11, 2012, Pages 822-827

  Robach, Paul ^a   Siebenmann, Christoph ^b   Jacobs, Robert A ^b   Rasmussen, Peter ^b   Nordsborg, Nikolai ^c   Pesta, Dominik ^d   Gnaiger, Erich ^d   Díaz, Víctor ^b   Christ, Andreas ^e   Fiedler, Julia ^f   Crivelli, Nadine ^f   Secher, Niels H ^c   Pichon, Aurélien ^g   Maggiorini, Marco ^e   Lundby, Carsten ^b  

^a Ecole Nationale de Ski et d'Alpinisme   (France)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f Hôpital la Vallée   (Switzerland)

^g UNIVERSITÉ PARIS 13   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ADULT; ALTITUDE; ARTICLE; DEMOGRAPHY; EXERCISE; EXERCISE TOLERANCE; FEMALE; HEMODILUTION; HUMAN; MALE; METABOLISM; METHODOLOGY; MUSCLE MITOCHONDRION; OXYGEN CONSUMPTION; PHYSIOLOGY; SKELETAL MUSCLE;

ADULT; ALTITUDE; EXERCISE; EXERCISE TOLERANCE; FEMALE; HEMODILUTION; HEMOGLOBINS; HUMANS; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; RESIDENCE CHARACTERISTICS;

EID: 84865415664     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsports-2012-091078     Document Type: Article

References (48)

1. Levine BD, Stray-Gundersen J. A practical approach to altitude training: where to live and train for optimal performance enhancement. Int J Sports Med 1992;13 (Suppl 1):S209-12.
2. Levine BD, Stray-Gundersen J. 'Living high-training low': effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 1997;83:102-12.
3. Stray-Gundersen J, Chapman RF, Levine BD. 'Living high-training low' altitude training improves sea level performance in male and female elite runners. J Appl Physiol 2001;91:1113-20.
4. Levine BD, Stray-Gundersen J. Point: positive effects of intermittent hypoxia (live high: train low) on exercise performance are mediated primarily by augmented red cell volume. J Appl Physiol 2005;99:2053-5.
5. Gore CJ, Hopkins WG. Counterpoint: positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume. J Appl Physiol 2005;99:2055-7; discussion 2057-8.
6. Bonetti DL, Hopkins WG. Sea-level exercise performance following adaptation to hypoxia: a meta-analysis. Sports Med 2009;39:107-27.
7. Gore CJ, Clark SA, Saunders PU. Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Med Sci Sports Exerc 2007;39:1600-9.
8. Weil JV, Jamieson G, Brown DW, et al. The red cell mass - arterial oxygen relationship in normal man. Application to patients with chronic obstructive airway disease. J Clin Invest 1968;47:1627-39.
9. Clark SA, Quod MJ, Clark MA, et al. Time course of haemoglobin mass during 21 days live high: train low simulated altitude. Eur J Appl Physiol 2009;106:399-406.
10. Garvican LA, Pottgiesser T, Martin DT, et al. The contribution of haemoglobin mass to increases in cycling performance induced by simulated LHTL. Eur J Appl Physiol 2011;111:1089-101.
11. Brugniaux JV, Schmitt L, Robach P, et al. Eighteen days of 'living high, training low' stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners. J Appl Physiol 2006;100:203-11.
12. Robach P, Schmitt L, Brugniaux JV, et al. Living high-training low: effect on erythropoiesis and aerobic performance in highly-trained swimmers. Eur J Appl Physiol 2006;96:423-33.
13. Robertson EY, Saunders PU, Pyne DB, et al. Reproducibility of performance changes to simulated live high/train low altitude. Med Sci Sports Exerc 2010;42:394-401.
14. Wehrlin JP, Zuest P, Hallen J, et al. Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes. J Appl Physiol 2006;100:1938-45.
15. Saunders PU, Ahlgrim C, Vallance B, et al. An attempt to quantify the placebo effect from a three-week simulated altitude training camp in elite race walkers. Int J Sports Physiol Perform 2010;5:521-34.
16. Kanstrup IL, Ekblom B. Blood volume and hemoglobin concentration as determinants of maximal aerobic power. Med Sci Sports Exerc 1984;16:256-62.
17. Ekblom B, Berglund B. Effect of erythropoietin administration on maximal aerobic power. Scand J Med Sci Sports 1991;1:88-93.
18. Lundby C, Robach P, Boushel R, et al. Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? J Appl Physiol 2008;105:581-7.
19. Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol 1998;85:1448-56.
20. Neya M, Enoki T, Kumai Y, et al. The effects of nightly normobaric hypoxia and high intensity training under intermittent normobaric hypoxia on running economy and hemoglobin mass. J Appl Physiol 2007;103:828-34.
21. Saunders PU, Telford RD, Pyne DB, et al. Improved running economy in elite runners after 20 days of simulated moderate-altitude exposure. J Appl Physiol 2004;96:931-7.
22. Gore CJ, Hahn AG, Aughey RJ, et al. Live high: train low increases muscle buffer capacity and submaximal cycling efficiency. Acta Physiol Scand 2001;173:275-86.
23. Ponsot E, Dufour SP, Zoll J, et al. Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle. J Appl Physiol 2006;100:1249-57.
24. Mizuno M, Savard GK, Areskog NH, et al. Skeletal muscle adaptations to prolonged exposure to extreme altitude: a role of physical activity? High Alt Med Biol 2008;9:311-17.
25. Lundby C, Calbet JA, Sander M, et al. Exercise economy does not change after acclimatization to moderate to very high altitude. Scand J Med Sci Sports 2007;17:281-91.
26. Siebenmann C, Robach P, Jacobs RA, et al. 'Live high - train low' using normobaric hypoxia: a double-blinded, placebo-controlled study. J Appl Physiol 2012;112:106-17.
27. Nordsborg NB, Siebenmann C, Jacobs RA, et al. Four weeks of normobaric 'Live High - Train Low' does not alter muscular or systemic capacity for maintaining pH and K+ homeostasis during intense exercise. J Appl Physiol 2012;112:2027-36.
28. American Thoracic Society, American College of Chest Physicians. ATS/ACCP statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 2003;167:211-77.
29. Lundby C, Thomsen JJ, Boushel R, et al. Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J Physiol 2007;578:309-14.
30. Burge CM, Skinner SL. Determination of hemoglobin mass and blood volume with CO: evaluation and application of a method. J Appl Physiol 1995;79:623-31.
31. Jacobs RA, Rasmussen P, Siebenmann C, et al. Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol 2011;111:1422-30.
32. Turner DL, Hoppeler H, Noti C, et al. Limitations to VO2max in humans after blood retransfusion. Respir Physiol 1993;92:329-41.
33. Burnley M, Roberts CL, Thatcher R, et al. Influence of blood donation on O2 uptake on-kinetics, peak O2 uptake and time to exhaustion during severe-intensity cycle exercise in humans. Exp Physiol 2006;91:499-509.
34. Calbet JA, Lundby C, Koskolou M, et al. Importance of hemoglobin concentration to exercise: acute manipulations. Respir Physiol Neurobiol 2006;151:132-40.
35. Warburton DE, Gledhill N, Jamnik VK, et al. Induced hypervolemia, cardiac function, VO2max, and performance of elite cyclists. Med Sci Sports Exerc 1999;31:800-8.
36. McKenzie DC, Lama IL, Potts JE, et al. The effect of repeat exercise on pulmonary diffusing capacity and EIH in trained athletes. Med Sci Sports Exerc 1999;31:99-104.
37. Caillaud CF, Anselme FM, Prefaut CG. Effects of two successive maximal exercise tests on pulmonary gas exchange in athletes. Eur J Appl Physiol Occup Physiol 1996;74:141-7.
38. Hoppeler H, Kleinert E, Schlegel C, et al. Morphological adaptations of human skeletal muscle to chronic hypoxia. Int J Sports Med 1990;11(Suppl 1):S3-9.
39. Howald H, Pette D, Simoneau JA, et al. Effect of chronic hypoxia on muscle enzyme activities. Int J Sports Med 1990;11(Suppl 1):S10-14.
40. Vigano A, Ripamonti M, De Palma S, et al. Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. Proteomics 2008;8:4668-79.
41. Green H, Roy B, Grant S, et al. Downregulation in muscle Na(+)-K(+)-ATPase following a 21-day expedition to 6194 m. J Appl Physiol 2000;88:634-40.
42. Green HJ, Sutton JR, Cymerman A, et al. Operation Everest II: adaptations in human skeletal muscle. J Appl Physiol 1989;66:2454-61.
43. Green HJ, Sutton JR, Wolfel EE, et al. Altitude acclimatization and energy metabolic adaptations in skeletal muscle during exercise. J Appl Physiol 1992;73:2701-8.
44. Young AJ, Evans WJ, Fisher EC, et al. Skeletal muscle metabolism of sea-level natives following short-term high-altitude residence. Eur J Appl Physiol Occup Physiol 1984;52:463-6.
45. Jacobs RA, Boushel R, Wright-Paradis C, et al. Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol 2012 DOI:10.1113/ expphysiol.2012.06.6092.
46. Saunders PU, Pyne DB, Telford RD, et al. Factors affecting running economy in trained distance runners. Sports Med 2004;34:465-85.
47. Millet GP, Faiss R, Pialoux V. Point: counterpoint: hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia. J Appl Physiol 2012;112:1783-4.
48. Mounier R, Brugniaux JV. Counterpoint: hypobaric hypoxia does not induce different responses from normobaric hypoxia. J Appl Physiol 2012;112:1784-6.