The effects of nightly normobaric hypoxia and high intensity training under intermittent normobaric hypoxia on running economy and hemoglobin mass

Journal of Applied Physiology

Volumn 103, Issue 3, 2007, Pages 828-834

  Neya, Mituso ^a   Enoki, Taisuke ^b   Kumai, Yasuko ^b   Sugoh, Takayuki ^b   Kawahara, Takashi ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN INSTITUTE OF SPORTS SCIENCES   (Japan)

Author keywords

Intermittent hypoxia; Oxygen uptake; Running economy

Indexed keywords

HEMOGLOBIN; OXYGEN;

ADULT; AEROBIC EXERCISE; ARTICLE; CONTROLLED STUDY; ERYTHROPOIESIS; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; PRIORITY JOURNAL; REBREATHING; RUNNING;

ADULT; ALTITUDE; ANOXIA; HEMOGLOBINS; HUMANS; MALE; OXYGEN; RUNNING; TIME FACTORS;

EID: 34548390981     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00265.2007     Document Type: Article

References (51)

1. Ashenden MJ, Gore CJ, Dobson GP, Hahn AG. "Live high, train low" does not change the total haemoglobin mass of male endurance athletes sleeping at a simulated altitude of 3000 m for 23 nights. Eur J Appl Physiol 80: 479-484, 1999.
2. +-ATPase activity in well-trained athletes. J Appl Physiol 98: 186-192, 2005.
3. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT. Increased dependence on blood glucose after acclimatization to 4,300 m. J Appl Physiol 70: 919-927, 1991.
4. Brooks GA, Wolfel EE, Groves BM, Bender PR, Butterfield GE, Cymerman A, Mazzeo RS, Sutton JR, Wolfe RR, Reeves JT. Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m. J Appl Physiol 72: 2435-2445, 1992.
5. Burge CM, Skinner SL. Determination of hemoglobin mass and blood volume with CO: evaluation and application of a method. J Appl Physiol 79: 623-631, 1995.
6. Conley DL, Krahenbuhl GS. Running economy and distance running performance of highly trained athletes. Med Sci Sports Exerc 12: 357-360, 1980.
7. Costill DL, Thomason H, Roberts E. Fractional utilization of the aerobic capacity during distance running. Med Sci Sports 5: 248-252, 1973.
8. Dick FW. Training at altitude in practice. Int J Sports Med 13, Suppl 1: S203-206, 1992.
9. Dufour SP, Ponsot E, Zoll J, Doutreleau S, Lonsdorfer-Wolf E, Geny B, Lampert E, Fluck M, Hoppeler H, Billat V, Mettauer B, Richard R, Lonsdorfer J. Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity. J Appl Physiol 100: 1238-1248, 2006.
10. Gore CJ, Hopkins WG. Counterpoint: Positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume. J Appl Physiol 99: 2055-2058, 2005.
11. Gore CJ, Hahn AG, Aughey RJ, Martin DT, Ashenden MJ, Clark SA, Garnham AP, Roberts AD, Slater GJ, McKenna MJ. Live high:train low increases muscle buffer capacity and submaximal cycling efficiency. Acta Physiol Scand 173: 275-286, 2001.
12. Grassi B, Marzorati M, Kayser B, Bordini M, Colombini A, Conti M, Marconi C, Cerretelli P. Peak blood lactate and blood lactate vs. workload during acclimatization to 5,050 m and in deacclimatization. J Appl Physiol 80: 685-692, 1996.
13. +-ATPase pumps in skeletal muscle with training in normobaric hypoxia. J Appl Physiol 86: 1745-1748, 1999.
14. +-ATPase following a 21-day expedition to 6,194 m. J Appl Physiol 88: 634-640, 2000.
15. Green HJ, Roy B, Grant S, Hughson R, Burnett M, Otto C, Pipe A, McKenzie D, Johnson M. Increases in submaximal cycling efficiency mediated by altitude acclimatization. J Appl Physiol 89: 1189-1197, 2000.
16. Hochachka PW, Stanley C, Matheson GO, McKenzie DC, Allen PS, Parkhouse WS. Metabolic and work efficiencies during exercise in Andean natives. J Appl Physiol 70: 1720-1730, 1991.
17. Julian CG, Gore CJ, Wilber RL, Daniels JT, Fredericson M, Stray-Gundersen J, Hahn AG, Parisotto R, Levine BD. Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. J Appl Physiol 96: 1800-1807, 2004.
18. Kacin A, Golja P, Eiken O, Tipton MJ, Mekjavic IB. The influence of acute and 23 days of intermittent hypoxic exposures on the exercise-induced forehead sweating response. Eur J Appl Physiol 99: 557-566, 2007.
19. Katayama K, Matsuo H, Ishida K, Mori S, Miyamura M. Intermittent hypoxia improves endurance performance and submaximal exercise efficiency. High Alt Med Biol 4: 291-304, 2003.
20. Katayama K, Sato K, Matsuo H, Ishida K, Iwasaki K, Miyamura M. Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance athletes. Eur J Appl Physiol 92: 75-83, 2004.
21. Knaupp W, Khilnani S, Sherwood J, Scharf S, Steinberg H. Erythropoietin response to acute normobaric hypoxia in humans. J Appl Physiol 73: 837-840, 1992.
22. Koistinen PO, Rusko H, Irjala K, Rajamaki A, Penttinen K, Sarparanta VP, Karpakka J, Leppaluoto J. EPO, red cells, and serum transferrin receptor in continuous and intermittent hypoxia. Med Sci Sports Exerc 32: 800-804, 2000.
23. Levine BD, Stray-Gundersen J. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 83: 102-112, 1997.
24. Levine BD, Stray-Gundersen J. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 83: 102-112, 1997.
25. Levine BD, Stray-Gundersen J. The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise. Adv Exp Med Biol 502: 75-88, 2001.
26. Levine BD, Stray-Gundersen J. Point: Positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume. J Appl Physiol 99: 2053-2055, 2005.
27. Lundby C, Calbet JAL, Sandar M, van Hall G, Mazzeo RS, Stray-Gundersen J, Stager JM, Chapman RF, Saltin B, Levine BD. Exercise economy does not change after acclimatization to moderate to very high altitude. Scand J Med Sci Sports 17: 281-291, 2007.
28. MacDonald MJ, Green HJ, Naylor HL, Otto C, Hughson RL. Reduced oxygen uptake during steady state exercise after 21-day mountain climbing expedition to 6,194 m. Can J Appl Physiol 26: 143-156, 2001.
29. Meeuwsen T, Hendriksen IJ, Holewijn M. Training-induced increases in sea-level performance are enhanced by acute intermittent hypobaric hypoxia. Eur J Appl Physiol 84: 283-290, 2001.
30. Millet GP, Boissiere D, Candau R. Energy cost of different skating techniques in cross-country skiing. J Sports Sci 21: 3-11, 2003.
31. Morgan DW, Martin PE, Krahenbuhl GS. Factors affecting running economy. Sports Med 7: 310-330, 1989.
32. Nummela A, Rusko H. Acclimatization to altitude and normoxic training improve 400-m running performance at sea level. J Sports Sci 18: 411-419, 2000.
33. Piehl Aulin K, Svedenhag J, Wide L, Berglund B, Saltin B. Short-term intermittent normobaric hypoxia - haematological, physiological and mental effects. Scand J Med Sci Sports 8: 132-137, 1998.
34. Robach P, Schmitt L, Brugniaux JV, Nicolet G, Duvallet A, Fouillot JP, Moutereau S, Lasne F, Pialoux V, Olsen NV, Richalet JP. Living high-training low: effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers. Eur J Appl Physiol 97: 695-705, 2006.
35. Roberts AC, Butterfield GE, Cymerman A, Reeves JT, Wolfel EE, Brooks GA. Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate. J Appl Physiol 81: 1762-1771, 1996.
36. Roberts AC, Reeves JT, Butterfield GE, Mazzeo RS, Sutton JR, Wolfel EE, Brooks GA. Altitude and beta-blockade augment glucose utilization during submaximal exercise. J Appl Physiol 80: 605-615, 1996.
37. Rodriguez FA, Truijens MJ, Townsend NE, Martini ER, Stray-Gundersen J, Gore CJ, Levine BD. Effects of four weeks of intermittent hypobaric hypoxia on sea level running and swimming performance. Med Sci Sports Exerc 36: S338, 2004.
38. Rodriguez FA, Casas H, Casas M, Pages T, Rama R, Ricart A, Ventura JL, Ibanez J, Viscor G. Intermittent hypobaric hypoxia stimulates erythropoiesis and improves aerobic capacity. Med Sci Sports Exerc 31: 264-268, 1999.
39. Roels B, Millet GP, Marcoux CJ, Coste O, Bentley DJ, Candau RB. Effects of hypoxic interval training on cycling performance. Med Sci Sports Exerc 37: 138-146, 2005.
40. Rusko HK, Tikkanen HO, Peltonen JE. Altitude and endurance training. J Sports Sci 22: 928-945, 2004.
41. Saunders PU, Telford RD, Pyne DB, Cunningham RB, Gore CJ, Hahn AG, Hawley JA. Improved running economy in elite runners after 20 days of simulated moderate-altitude exposure. J Appl Physiol 96: 931-937, 2004.
42. Schmitt L, Millet G, Robach P, Nicolet G, Brugniaux JV, Fouillot JP, Richalet JP. Influence of "living high-training low" on aerobic performance and economy of work in elite athletes. Eur J Appl Physiol 97: 627-636, 2006.
43. Stray-Gundersen J, Chapman RF, Levine BD. "Living high-training low" altitude training improves sea level performance in male and female elite runners. J Appl Physiol 91: 1113-1120, 2001.
44. Terrados N, Melichna J, Sylven C, Jansson E, Kaijser L. Effects of training at simulated altitude on performance and muscle metabolic capacity in competitive road cyclists. Eur J Appl Physiol Occup Physiol 57: 203-209, 1988.
45. Toussaint HM, Hollander AP. Energetics of competitive swimming. Implications for training programmes. Sports Med 18: 384-405, 1994.
46. Truijens MJ, Toussaint HM, Dow J, Levine BD. Effect of high-intensity hypoxic training on sea-level swimming performances. J Appl Physiol 94: 733-743, 2003.
47. Vallier JM, Chateau P, Guezennec CY. Effects of physical training in a hypobaric chamber on the physical performance of competitive triathletes. Eur J Appl Physiol Occup Physiol 73: 471-478, 1996.
48. Ventura N, Hoppeler H, Seiler R, Binggeli A, Mullis P, Vogt M. The response of trained athletes to six weeks of endurance training in hypoxia or normoxia. Int J Sports Med 24: 166-172, 2003.
49. Weil JV, Jamieson G, Brown DW, Grover RF. The red cell massarterial oxygen relationship in normal man. Application to patients with chronic obstructive airway disease. J Clin Invest 47: 1627-1639, 1968.
50. Wolfel EE, Groves BM, Brooks GA, Butterfield GE, Mazzeo RS, Moore LG, Sutton JR, Bender PR, Dahms TE, McCullough RE. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J Appl Physiol 70: 1129-1136, 1991.
51. Young AJ, Evans WJ, Cymerman A, Pandolf KB, Knapik JJ, Maher JT. Sparing effect of chronic high-altitude exposure on muscle glycogen utilization. J Appl Physiol 52: 857-862, 1982.