메뉴 건너뛰기




Volumn 16, Issue 9, 2012, Pages 2186-2195

Analysis of molecular mechanisms and anti-tumoural effects of zoledronic acid in breast cancer cells

Author keywords

Breast cancer; FN1; Invasion; TGF 1; THBS 1; ZOL

Indexed keywords


EID: 84865405372     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2012.01527.x     Document Type: Article
Times cited : (26)

References (56)
  • 1
    • 0030879065 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Mundy GR. Mechanisms of bone metastasis. Cancer. 1997; 80: 1546-56.
    • (1997) Cancer , vol.80 , pp. 1546-1556
    • Mundy, G.R.1
  • 2
    • 58149198581 scopus 로고    scopus 로고
    • Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy
    • Lipton A, Steger GG, Figueroa J, et al. Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy. Clin Cancer Res. 2008; 14: 6690-6.
    • (2008) Clin Cancer Res , vol.14 , pp. 6690-6696
    • Lipton, A.1    Steger, G.G.2    Figueroa, J.3
  • 3
    • 0030927205 scopus 로고    scopus 로고
    • Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2
    • Yoneda T, Sasaki A, Dunstan C, et al. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J Clin Invest. 1997; 99: 2509-17.
    • (1997) J Clin Invest. , vol.99 , pp. 2509-2517
    • Yoneda, T.1    Sasaki, A.2    Dunstan, C.3
  • 4
    • 0034214362 scopus 로고    scopus 로고
    • Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
    • Boissier S, Ferreras M, Peyruchaud O, et al. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res. 2000; 60: 2949-54.
    • (2000) Cancer Res. , vol.60 , pp. 2949-2954
    • Boissier, S.1    Ferreras, M.2    Peyruchaud, O.3
  • 5
    • 0038792653 scopus 로고    scopus 로고
    • New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects
    • Denoyelle C, Hong L, Vannier JP, et al. New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects. Br J Cancer. 2003; 88: 1631-40.
    • (2003) Br J Cancer. , vol.88 , pp. 1631-1640
    • Denoyelle, C.1    Hong, L.2    Vannier, J.P.3
  • 6
    • 0037664952 scopus 로고    scopus 로고
    • Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells
    • Oades GM, Senaratne SG, Clarke IA, et al. Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells. J Urol. 2003; 170: 246-52.
    • (2003) J Urol. , vol.170 , pp. 246-252
    • Oades, G.M.1    Senaratne, S.G.2    Clarke, I.A.3
  • 7
  • 8
    • 33644539542 scopus 로고    scopus 로고
    • A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
    • Monkkonen H, Auriola S, Lehenkari P, et al. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. Br J Pharmacol. 2006; 147: 437-45.
    • (2006) Br J Pharmacol. , vol.147 , pp. 437-445
    • Monkkonen, H.1    Auriola, S.2    Lehenkari, P.3
  • 9
    • 0037241535 scopus 로고    scopus 로고
    • In vitro and in vivo antitumour effects of bisphosphonates
    • Clezardin P, Fournier P, Boissier S, et al. In vitro and in vivo antitumour effects of bisphosphonates. Curr Med Chem. 2003; 10: 173-80.
    • (2003) Curr Med Chem. , vol.10 , pp. 173-180
    • Clezardin, P.1    Fournier, P.2    Boissier, S.3
  • 10
    • 0036093899 scopus 로고    scopus 로고
    • Pamidronate induces modifications of circulating angiogenetic factors in cancer patients
    • Santini D, Vincenzi B, Avvisati G, et al. Pamidronate induces modifications of circulating angiogenetic factors in cancer patients. Clin Cancer Res. 2002; 8: 1080-4.
    • (2002) Clin Cancer Res. , vol.8 , pp. 1080-1084
    • Santini, D.1    Vincenzi, B.2    Avvisati, G.3
  • 11
    • 10744227993 scopus 로고    scopus 로고
    • Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients
    • Santini D, Vincenzi B, Dicuonzo G, et al. Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res. 2003; 9: 2893-7.
    • (2003) Clin Cancer Res. , vol.9 , pp. 2893-2897
    • Santini, D.1    Vincenzi, B.2    Dicuonzo, G.3
  • 12
    • 37049006066 scopus 로고    scopus 로고
    • Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumour-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumour stroma
    • Melani C, Sangaletti S, Barazzetta FM, et al. Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumour-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumour stroma. Cancer Res. 2007; 67: 11438-46.
    • (2007) Cancer Res. , vol.67 , pp. 11438-11446
    • Melani, C.1    Sangaletti, S.2    Barazzetta, F.M.3
  • 13
    • 0344845001 scopus 로고    scopus 로고
    • Tissue architecture: the ultimate regulator of breast epithelial function
    • Bissell MJ, Rizki A, Mian IS. Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol. 2003; 15: 753-62.
    • (2003) Curr Opin Cell Biol. , vol.15 , pp. 753-762
    • Bissell, M.J.1    Rizki, A.2    Mian, I.S.3
  • 14
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
    • Weaver VM, Petersen OW, Wang F, et al. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 1997; 137: 231-45.
    • (1997) J Cell Biol. , vol.137 , pp. 231-245
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3
  • 15
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003; 30: 256-68.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 16
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1: 27-31.
    • (1995) Nat Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 17
    • 78650476382 scopus 로고    scopus 로고
    • The transforming growth factor beta 1/SMAD signaling pathway involved in human chronic myeloid leukemia
    • Su E, Han X, Jiang G. The transforming growth factor beta 1/SMAD signaling pathway involved in human chronic myeloid leukemia. Tumori. 2010; 96: 659-66.
    • (2010) Tumori , vol.96 , pp. 659-666
    • Su, E.1    Han, X.2    Jiang, G.3
  • 18
    • 0030183051 scopus 로고    scopus 로고
    • Tumour suppressor activity of the TGF-beta pathway in human cancers
    • Markowitz SD, Roberts AB. Tumour suppressor activity of the TGF-beta pathway in human cancers. Cytokine Growth Factor Rev. 1996; 7: 93-102.
    • (1996) Cytokine Growth Factor Rev. , vol.7 , pp. 93-102
    • Markowitz, S.D.1    Roberts, A.B.2
  • 19
    • 0033561642 scopus 로고    scopus 로고
    • Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol
    • Ariazi EA, Satomi Y, Ellis MJ, et al. Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Res. 1999; 59: 1917-28.
    • (1999) Cancer Res. , vol.59 , pp. 1917-1928
    • Ariazi, E.A.1    Satomi, Y.2    Ellis, M.J.3
  • 20
    • 0034742274 scopus 로고    scopus 로고
    • Extraction and purification of TGFbeta and its effect on the induction of apoptosis of hepatocytes
    • Si XH, Yang LJ. Extraction and purification of TGFbeta and its effect on the induction of apoptosis of hepatocytes. World J Gastroenterol. 2001; 7: 527-31.
    • (2001) World J Gastroenterol. , vol.7 , pp. 527-531
    • Si, X.H.1    Yang, L.J.2
  • 21
    • 0029347102 scopus 로고
    • Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1
    • Bornstein P. Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J Cell Biol. 1995; 130: 503-6.
    • (1995) J Cell Biol. , vol.130 , pp. 503-506
    • Bornstein, P.1
  • 22
    • 0033027727 scopus 로고    scopus 로고
    • Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat
    • Dawson DW, Volpert OV, Pearce SF, et al. Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. Mol Pharmacol. 1999; 55: 332-8.
    • (1999) Mol Pharmacol. , vol.55 , pp. 332-338
    • Dawson, D.W.1    Volpert, O.V.2    Pearce, S.F.3
  • 23
    • 0030833817 scopus 로고    scopus 로고
    • CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells
    • Dawson DW, Pearce SF, Zhong R, et al. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol. 1997; 138: 707-17.
    • (1997) J Cell Biol. , vol.138 , pp. 707-717
    • Dawson, D.W.1    Pearce, S.F.2    Zhong, R.3
  • 24
    • 0033574442 scopus 로고    scopus 로고
    • Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98
    • Chandrasekaran S, Guo NH, Rodrigues RG, et al. Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98. J Biol Chem. 1999; 274: 11408-16.
    • (1999) J Biol Chem. , vol.274 , pp. 11408-11416
    • Chandrasekaran, S.1    Guo, N.H.2    Rodrigues, R.G.3
  • 25
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008; 214: 199-210.
    • (2008) J Pathol. , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 26
    • 0034650566 scopus 로고    scopus 로고
    • Thrombospondin-1 promotes alpha3beta1 integrin-mediated adhesion and neurite-like outgrowth and inhibits proliferation of small cell lung carcinoma cells
    • Guo N, Templeton NS, Al-Barazi H, et al. Thrombospondin-1 promotes alpha3beta1 integrin-mediated adhesion and neurite-like outgrowth and inhibits proliferation of small cell lung carcinoma cells. Cancer Res. 2000; 60: 457-66.
    • (2000) Cancer Res. , vol.60 , pp. 457-466
    • Guo, N.1    Templeton, N.S.2    Al-Barazi, H.3
  • 27
    • 0025823515 scopus 로고
    • Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin
    • Sage EH, Bornstein P. Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin. J Biol Chem. 1991; 266: 14831-4.
    • (1991) J Biol Chem. , vol.266 , pp. 14831-14834
    • Sage, E.H.1    Bornstein, P.2
  • 28
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumours
    • Ramaswamy S, Ross KN, Lander ES, et al. A molecular signature of metastasis in primary solid tumours. Nat Genet. 2003; 33: 49-54.
    • (2003) Nat Genet. , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3
  • 29
    • 4344688268 scopus 로고    scopus 로고
    • Global expression profiling identifies signatures of tumour virulence in MMTV-PyMT-transgenic mice: correlation to human disease
    • Qiu TH, Chandramouli GV, Hunter KW, et al. Global expression profiling identifies signatures of tumour virulence in MMTV-PyMT-transgenic mice: correlation to human disease. Cancer Res. 2004; 64: 5973-81.
    • (2004) Cancer Res. , vol.64 , pp. 5973-5981
    • Qiu, T.H.1    Chandramouli, G.V.2    Hunter, K.W.3
  • 30
    • 34250656634 scopus 로고    scopus 로고
    • Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients
    • Feng Y, Sun B, Li X, et al. Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients. Breast Cancer Res Treat. 2007; 103: 319-29.
    • (2007) Breast Cancer Res Treat. , vol.103 , pp. 319-329
    • Feng, Y.1    Sun, B.2    Li, X.3
  • 31
    • 51649085736 scopus 로고    scopus 로고
    • Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumour growth and lung metastasis
    • Calvo A, Catena R, Noble MS, et al. Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumour growth and lung metastasis. Oncogene. 2008; 27: 5373-84.
    • (2008) Oncogene , vol.27 , pp. 5373-5384
    • Calvo, A.1    Catena, R.2    Noble, M.S.3
  • 32
    • 67549125238 scopus 로고    scopus 로고
    • Gene expression profiling of the tumour microenvironment during breast cancer progression
    • Ma XJ, Dahiya S, Richardson E, et al. Gene expression profiling of the tumour microenvironment during breast cancer progression. Breast Cancer Res. 2009; 11: R7.
    • (2009) Breast Cancer Res. , vol.11
    • Ma, X.J.1    Dahiya, S.2    Richardson, E.3
  • 33
    • 0036468926 scopus 로고    scopus 로고
    • Tumour-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer
    • Yi B, Williams PJ, Niewolna M, et al. Tumour-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res. 2002; 62: 917-23.
    • (2002) Cancer Res. , vol.62 , pp. 917-923
    • Yi, B.1    Williams, P.J.2    Niewolna, M.3
  • 34
    • 0037112368 scopus 로고    scopus 로고
    • Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats
    • Fournier P, Boissier S, Filleur S, et al. Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer Res. 2002; 62: 6538-44.
    • (2002) Cancer Res. , vol.62 , pp. 6538-6544
    • Fournier, P.1    Boissier, S.2    Filleur, S.3
  • 35
    • 1342288026 scopus 로고    scopus 로고
    • affy-analysis of Affymetrix GeneChip data at the probe level
    • Gautier L, Cope L, Bolstad BM, et al. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 2004; 20: 307-15.
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3
  • 36
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003; 4: 249-64.
    • (2003) Biostatistics , vol.4 , pp. 249-264
    • Irizarry, R.A.1    Hobbs, B.2    Collin, F.3
  • 37
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3.
    • Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004; 3: Article3.
    • (2004) Stat Appl Genet Mol Biol. , vol.3
    • Smyth, G.K.1
  • 38
    • 0035829361 scopus 로고    scopus 로고
    • Controlling the false discovery rate in behavior genetics research
    • Benjamini Y, Drai D, Elmer G, et al. Controlling the false discovery rate in behavior genetics research. Behav Brain Res. 2001; 125: 279-84.
    • (2001) Behav Brain Res. , vol.125 , pp. 279-284
    • Benjamini, Y.1    Drai, D.2    Elmer, G.3
  • 39
    • 33645287677 scopus 로고    scopus 로고
    • affylmGUI: a graphical user interface for linear modeling of single channel microarray data
    • Wettenhall JM, Simpson KM, Satterley K, et al. affylmGUI: a graphical user interface for linear modeling of single channel microarray data. Bioinformatics. 2006; 22: 897-9.
    • (2006) Bioinformatics , vol.22 , pp. 897-899
    • Wettenhall, J.M.1    Simpson, K.M.2    Satterley, K.3
  • 40
    • 34147222698 scopus 로고    scopus 로고
    • R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation
    • Caraglia M, Marra M, Leonetti C, et al. R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation. J Cell Physiol. 2007; 211: 533-43.
    • (2007) J Cell Physiol. , vol.211 , pp. 533-543
    • Caraglia, M.1    Marra, M.2    Leonetti, C.3
  • 41
    • 3242771333 scopus 로고    scopus 로고
    • Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation
    • Coxon JP, Oades GM, Kirby RS, et al. Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation. BJU Int. 2004; 94: 164-70.
    • (2004) BJU Int. , vol.94 , pp. 164-170
    • Coxon, J.P.1    Oades, G.M.2    Kirby, R.S.3
  • 42
    • 20444445149 scopus 로고    scopus 로고
    • Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy
    • Sato K, Kimura S, Segawa H, et al. Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy. Int J Cancer. 2005; 116: 94-9.
    • (2005) Int J Cancer , vol.116 , pp. 94-99
    • Sato, K.1    Kimura, S.2    Segawa, H.3
  • 43
    • 70249139162 scopus 로고    scopus 로고
    • Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells
    • Marra M, Santini D, Meo G, et al. Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells. Int J Cancer. 2009; 125: 2004-13.
    • (2009) Int J Cancer , vol.125 , pp. 2004-2013
    • Marra, M.1    Santini, D.2    Meo, G.3
  • 44
    • 4644228513 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate
    • Caraglia M, D'Alessandro AM, Marra M, et al. The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate. Oncogene. 2004; 23: 6900-13.
    • (2004) Oncogene , vol.23 , pp. 6900-6913
    • Caraglia, M.1    D'Alessandro, A.M.2    Marra, M.3
  • 45
    • 77957134474 scopus 로고    scopus 로고
    • Metronomic administration of zoledronic acid and taxotere combination in castration resistant prostate cancer patients: phase I ZANTE trial
    • Facchini G, Caraglia M, Morabito A, et al. Metronomic administration of zoledronic acid and taxotere combination in castration resistant prostate cancer patients: phase I ZANTE trial. Cancer Biol Ther. 2010; 10: 543-8.
    • (2010) Cancer Biol Ther. , vol.10 , pp. 543-548
    • Facchini, G.1    Caraglia, M.2    Morabito, A.3
  • 46
    • 77952305169 scopus 로고    scopus 로고
    • Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial
    • Aft R, Naughton M, Trinkaus K, et al. Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial. Lancet Oncol. 2010; 11: 421-8.
    • (2010) Lancet Oncol. , vol.11 , pp. 421-428
    • Aft, R.1    Naughton, M.2    Trinkaus, K.3
  • 47
    • 79957580066 scopus 로고    scopus 로고
    • Differential roles of Smad2 and Smad3 in the regulation of TGF-beta1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
    • Ungefroren H, Groth S, Sebens S, et al. Differential roles of Smad2 and Smad3 in the regulation of TGF-beta1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Mol Cancer. 2011; 10: 67.
    • (2011) Mol Cancer , vol.10 , pp. 67
    • Ungefroren, H.1    Groth, S.2    Sebens, S.3
  • 48
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGFbeta signaling
    • Massague J, Gomis RR. The logic of TGFbeta signaling. FEBS Lett. 2006; 580: 2811-20.
    • (2006) FEBS Lett. , vol.580 , pp. 2811-2820
    • Massague, J.1    Gomis, R.R.2
  • 49
    • 0037621860 scopus 로고    scopus 로고
    • Regulation of TGF-beta signaling and its roles in progression of tumours
    • Miyazono K, Suzuki H, Imamura T. Regulation of TGF-beta signaling and its roles in progression of tumours. Cancer Sci. 2003; 94: 230-4.
    • (2003) Cancer Sci , vol.94 , pp. 230-234
    • Miyazono, K.1    Suzuki, H.2    Imamura, T.3
  • 50
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signalling
    • ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem Sci. 2004; 29: 265-73.
    • (2004) Trends Biochem Sci , vol.29 , pp. 265-273
    • ten Dijke, P.1    Hill, C.S.2
  • 51
    • 45949099277 scopus 로고    scopus 로고
    • The bisphosphonate, zoledronic acid reduces experimental neuroblastoma growth by interfering with tumour angiogenesis
    • Backman U, Svensson A, Christofferson RH, et al. The bisphosphonate, zoledronic acid reduces experimental neuroblastoma growth by interfering with tumour angiogenesis. Anticancer Res. 2008; 28: 1551-7.
    • (2008) Anticancer Res. , vol.28 , pp. 1551-1557
    • Backman, U.1    Svensson, A.2    Christofferson, R.H.3
  • 52
    • 42549137841 scopus 로고    scopus 로고
    • Antitumoural and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model
    • Soltau J, Zirrgiebel U, Esser N, et al. Antitumoural and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. Anticancer Res. 2008; 28: 933-41.
    • (2008) Anticancer Res. , vol.28 , pp. 933-941
    • Soltau, J.1    Zirrgiebel, U.2    Esser, N.3
  • 53
    • 38749122501 scopus 로고    scopus 로고
    • Zoledronic acid is unable to induce apoptosis, but slows tumour growth and prolongs survival for non-small-cell lung cancers
    • Li YY, Chang JW, Chou WC, et al. Zoledronic acid is unable to induce apoptosis, but slows tumour growth and prolongs survival for non-small-cell lung cancers. Lung Cancer. 2008; 59: 180-91.
    • (2008) Lung Cancer , vol.59 , pp. 180-191
    • Li, Y.Y.1    Chang, J.W.2    Chou, W.C.3
  • 54
    • 58749100624 scopus 로고    scopus 로고
    • Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells
    • Karabulut B, Erten C, Gul MK, et al. Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells. Cell Biol Int. 2009; 33: 239-46.
    • (2009) Cell Biol Int. , vol.33 , pp. 239-246
    • Karabulut, B.1    Erten, C.2    Gul, M.K.3
  • 55
    • 33744995340 scopus 로고    scopus 로고
    • The regulatory effect of tamoxifen on fibronectin expression in oestrogen-dependent MCF-7 breast carcinoma cells
    • Horii Y, Takei H, Koibuchi Y, et al. The regulatory effect of tamoxifen on fibronectin expression in oestrogen-dependent MCF-7 breast carcinoma cells. Oncol Rep. 2006; 15: 1191-5.
    • (2006) Oncol Rep. , vol.15 , pp. 1191-1195
    • Horii, Y.1    Takei, H.2    Koibuchi, Y.3
  • 56
    • 0026609359 scopus 로고
    • Oestrogen treatment of Dunning tumours in castrated rats: qualitative and quantitative morphology
    • Landstrom M, Bergh A, Thornell LE, et al. Oestrogen treatment of Dunning tumours in castrated rats: qualitative and quantitative morphology. Prostate. 1992; 20: 199-211.
    • (1992) Prostate. , vol.20 , pp. 199-211
    • Landstrom, M.1    Bergh, A.2    Thornell, L.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.