HCV coinfection does not alter the frequency of regulatory T Cells or CD8+ T Cell immune activation in chronically infected HIV+ Chinese subjects

AIDS Research and Human Retroviruses

Volumn 28, Issue 9, 2012, Pages 844-851

  Zhuang, Yan ^a   Wei, Xiaoyan ^a   Li, Yuan ^a   Zhao, Ke ^a   Zhang, Jiucong ^a   Kang, Wenzhen ^a   Sun, Yongtao ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; HLA DR ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHINESE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; FEMALE; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; UPREGULATION; VIRUS LOAD;

EID: 84865391936     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2011.0318     Document Type: Article

References (52)

1. Operskalski EA and Kovacs A: HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies. Curr HIV/AIDS Rep 2011;8 (1): 12-22.
2. Weis N, Lindhardt BO, Kronborg G, et al.: Impact of hepatitis C virus coinfection on response to highly active antiretroviral therapy and outcome in HIV-infected individuals: A nationwide cohort study. Clin Infect Dis 2006;42 (10):1481-1487.
3. Sulkowski MS, Moore RD, Mehta SH, Chaisson RE, and Thomas DL: Hepatitis C and progression of HIV disease. JAMA 2002;288 (2):199-206
4. Rockstroh JK, Mocroft A, Soriano V, et al.: Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis 2005;192 (6):992-1002.
5. Dorrucci M, Valdarchi C, Suligoi B, et al.: The effect of hepatitis C on progression to AIDS before and after highly active antiretroviral therapy. AIDS 2004;18 (17):2313-2318. (Pubitemid 39620224)
6. Anderson KB, Guest JL, and Rimland D: Hepatitis C virus coinfection increases mortality in HIV-infected patients in the highly active antiretroviral therapy era: Data from the HIV Atlanta VA Cohort Study. Clin Infect Dis 2004;39 (10):1507-1513. (Pubitemid 39518216)
7. Chen TY, Ding EL, Seage GR, and Kim AY: Meta-analysis: Increased mortality associated with hepatitis C in HIV-infected persons is unrelated to HIV disease progression. Clin Infect Dis 2009;49 (10):1605-1615.
8. d'Arminio Monforte A, Cozzi-Lepri A, Castagna A, et al.: Risk of developing specific AIDS-defining illnesses in patients coinfected with HIV and hepatitis C virus with or without liver cirrhosis. Clin Infect Dis 2009;49 (4):612-622.
9. Kovacs A, Karim R, Mack WJ, et al.: Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis 2010;201 (6): 823-834.
10. Thornton AM and Shevach EM: CD4+ CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998;188 (2):287-296. (Pubitemid 28357757)
11. Takahashi T, Kuniyasu Y, Toda M, et al.: Immunologic selftolerance maintained by CD25 + CD4 + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998;10 (12):1969-1980. (Pubitemid 28566059)
12. O'Garra A and Vieira P: Regulatory T cells and mechanisms of immune system control. Nat Med 2004;10 (8):801-805. (Pubitemid 39070850)
13. Bluestone JA and Abbas AK: Natural versus adaptive regulatory T cells. Nat Rev Immunol 2003;3 (3):253-257. (Pubitemid 37323210)
14. Kinter AL, Hennessey M, Bell A, et al.: CD25 ( + )CD4 ( + ) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4 ( + ) and CD8 ( + ) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 2004;200 (3):331-343. (Pubitemid 39031252)
15. Weiss L, Donkova-Petrini V, Caccavelli L, Balbo M, Carbonneil C, and Levy Y: Human immunodeficiency virusdriven expansion of CD4 + CD25 + regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004;104 (10):3249-3256. (Pubitemid 39507143)
16. Kinter A, McNally J, Riggin L, Jackson R, Roby G, and Fauci AS: Suppression of HIV-specific T cell activity by lymph node CD25 + regulatory T cells from HIV-infected individuals. Proc Natl Acad Sci USA 2007;104 (9):3390-3395. (Pubitemid 46364169)
17. Epple HJ, Loddenkemper C, Kunkel D, et al.: Mucosal but not peripheral FOXP3 + regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 2006;108 (9):3072-3078.
18. Apoil PA, Puissant B, Roubinet F, Abbal M, Massip P, and Blancher A: FOXP3 mRNA levels are decreased in peripheral blood CD4+ lymphocytes from HIV-positive patients. J Acquir Immune Defic Syndr 2005;39 (4):381-385. (Pubitemid 41003779)
19. Nilsson J, Boasso A, Velilla PA, et al.: HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood 2006;108 (12): 3808-3817. (Pubitemid 44864563)
20. Cabrera R, Tu Z, Xu Y, et al.: An immunomodulatory role for CD4 ( + )CD25 ( + ) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004;40 (5):1062-1071. (Pubitemid 39425561)
21. Chase AJ, Yang HC, Zhang H, Blankson JN, and Siliciano RF: Preservation of FoxP3 + regulatory T cells in the peripheral blood of human immunodeficiency virus type 1- infected elite suppressors correlates with low CD4 + T-cell activation. J Virol 2008;82 (17):8307-8315.
22. Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, and Chang KM: Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 2003;38 (6):1437-1448. (Pubitemid 37466970)
23. Boettler T, Spangenberg HC, Neumann-Haefelin C, et al.: T cells with a CD4 + CD25 + regulatory phenotype suppress in vitro proliferation of virus-specific CD8 + T cells during chronic hepatitis C virus infection. J Virol 2005;79 (12):7860-7867. (Pubitemid 40756821)
24. Rushbrook SM, Ward SM, Unitt E, et al.: Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol 2005;79 (12):7852-7859. (Pubitemid 40756820)
25. Rallon NI, Lopez M, Soriano V, et al.: Level, phenotype and activation status of CD4+ FoxP3 + regulatory T cells in patients chronically infected with human immunodeficiency virus and/or hepatitis C virus. Clin Exp Immunol 2009;155 (1):35-43.
26. Roe B, Coughlan S, Dean J, et al.: Phenotypic characterization of lymphocytes in HCV/HIV co-infected patients. Viral Immunol 2009;22 (1):39-48.
27. Goulder PJ, Phillips RE, Colbert RA, et al.: Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat Med 1997;3 (2):212-217. (Pubitemid 27064707)
28. Price DA, Goulder PJ, Klenerman P, et al.: Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci USA 1997;94 (5):1890-1895. (Pubitemid 27113932)
29. Zhuang Y, Sun Y, Zhai S, et al.: Relative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection. Curr HIV Res 2008;6 (3):239-245. (Pubitemid 352024676)
30. Mohsen AH, Easterbrook P, Taylor CB, and Norris S: Hepatitis C and HIV-1 coinfection. Gut 2002;51 (4):601-608.
31. Graham CS, Baden LR, Yu E, et al.: Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis. Clin Infect Dis 2001;33 (4): 562-569. (Pubitemid 32709592)
32. Shepard CW, Finelli L, and Alter MJ: Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005;5 (9):558-567. (Pubitemid 41196755)
33. Greub G, Ledergerber B, Battegay M, et al.: Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: The Swiss HIV Cohort Study. Lancet 2000;356 (9244):1800-1805.
34. Lesens O, Deschenes M, Steben M, Belanger G, and Tsoukas C: Hepatitis C virus is related to progressive liver disease in human immunodeficiency virus-positive hemophiliacs and should be treated as an opportunistic infection. J Infect Dis 1999;179:1254-1258. (Pubitemid 29196510)
35. Daar ES, Lynn H, Donfield S, et al.: Hepatitis C virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs. J Infect Dis 2001;183 (4): 589-595. (Pubitemid 32147515)
36. Piroth L, Duong M, Quantin C, et al.: Does hepatitis C virus co-infection accelerate clinical and immunological evolution of HIV-infected patients AIDS 1998;12 (4):381-388.
37. Staples CT Jr, Rimland D, and Dudas D: Hepatitis C in the HIV (human immunodeficiency virus) Atlanta V.A. (Veterans Affairs Medical Center) Cohort Study (HAVACS): The effect of coinfection on survival. Clin Infect Dis 1999; 29 (1):150-154.
38. Dorrucci M, Pezzotti P, Phillips A, Cozzi Lepri A, and Rezza G: Coinfection of hepatitis C virus with human immunodeficiency virus and progression to AIDS. J Infect Dis 1995; 172 (6):1503-1508.
39. Bonacini M, Louie S, Bzowej N, and Wohl AR: Survival in patients with HIV infection and viral hepatitis B or C: A cohort study. AIDS 2004;18 (15):2039-2045. (Pubitemid 39463357)
40. Lincoln D, Petoumenos K, and Dore GJ: HIV/HBV and HIV/HCV coinfection, and outcomes following highly active antiretroviral therapy. HIV Med 2003;4 (3):241-249. (Pubitemid 36949880)
41. Manigold T, Shin EC, Mizukoshi E, et al.: Foxp3 + CD4 + CD25 + T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood 2006;107 (11):4424-4432. (Pubitemid 43801369)
42. Ndhlovu LC, Loo CP, Spotts G, Nixon DF, and Hecht FM: FOXP3 expressing CD127lo CD4 + T cells inversely correlate with CD38 + CD8 + T cell activation levels in primary HIV-1 infection. J Leukoc Biol 2008;83 (2):254-262. (Pubitemid 351225605)
43. Tsunemi S, Iwasaki T, Imado T, et al.: Relationship of CD4 + CD25 + regulatory T cells to immune status in HIV-infected patients. AIDS 2005;19 (9):879-886. (Pubitemid 40834930)
44. Andersson J, Boasso A, Nilsson J, et al.: The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J Immunol 2005;174 (6):3143-3147. (Pubitemid 40354012)
45. Eggena MP, Barugahare B, Jones N, et al.: Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 2005;174 (7):4407-4414. (Pubitemid 40396024)
46. Jiao Y, Fu J, Xing S, et al.: The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8 + T cells inHIV-1-infected typical progressors, but not in long-term non-progressors. Immunology 2009;128 (1 Suppl):e366-e375.
47. Cacoub P, Musset L, Hausfater P, et al.: No evidence for abnormal immune activation in peripheral blood T cells in patients with hepatitis C virus (HCV) infection with or without cryoglobulinaemia. Multivirc Group. Clin Exp Immunol 1998;113 (1):48-54. (Pubitemid 28329064)
48. Giovannetti A, Mazzetta F, Coviello R, et al.: T-cell immune activation in children with vertically transmitted hepatitis C virus infection. Viral Immunol 2001;14 (2):169-179. (Pubitemid 32506578)
49. Gonzalez VD, Falconer K, Blom KG, et al.: High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. J Virol 2009;83 (21):11407-11411.
50. Kovacs A, Al-Harthi L, Christensen S, Mack W, Cohen M, and Landay A: CD8 ( + ) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus. J Infect Dis 2008;197 (10):1402-1407. (Pubitemid 351706464)
51. Gray CM, Lawrence J, Schapiro JM, et al.: Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). J Immunol 1999;162 (3):1780-1788. (Pubitemid 29307058)
52. Papasavvas E, Ortiz GM, Gross R, et al.: Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption. J Infect Dis 2000; 182 (3):766-775.