CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Immunology Letters

Volumn 147, Issue 1-2, 2012, Pages 75-79

  Mizukami, Takahiro ^a   Kanai, Takanori ^a   Mikami, Yohei ^a   Hayashi, Atsushi ^a   Doi, Tomomitsu ^a   Handa, Tango ^a   Matsumoto, Atsuhiro ^a   Jun, Li ^a   Matsuoka, Katsuyoshi ^a   Sato, Toshiro ^a   Hisamatsu, Tadakazu ^a   Hibi, Toshifumi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CCR9; Macrophages; Peritonitis; Sepsis

Indexed keywords

CHEMOKINE RECEPTOR CCR9; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; IMMUNE RESPONSE; IMMUNOSTIMULATION; INFECTION CONTROL; INFECTION PREVENTION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEPSIS; WILD TYPE;

ANIMALS; BACTERIAL INFECTIONS; CYTOKINES; INFLAMMATION MEDIATORS; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PERITONEAL CAVITY; PERITONEAL DISEASES; PERITONITIS; RECEPTORS, CCR; SEPSIS;

EID: 84865379540     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.06.006     Document Type: Article

References (34)

1. Angus D.C., Linde-Zwirble W.T., Lidicker J., Clermont G., Carcillo J., Pinsky M.R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310.
2. Cohen J. The immunopathogenesis of sepsis. Nature 2002, 420:885-891.
3. Martin G.S., Mannino D.M., Eaton S., Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554.
4. Belaaouaj A., McCarthy R., Baumann M., Gao Z., Ley T.J., Abraham S.N., et al. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med 1998, 4:615-618.
5. Czermak B.J., Sarma V., Pierson C.L., Warner R.L., Huber-Lang M., Bless N.M., et al. Protective effects of C5a blockade in sepsis. Nat Med 1999, 5:788-792.
6. Dunn D.L. Antibody immunotherapy of gram-negative bacterial sepsis in an immunosuppressed animal model. Transplantation 1988, 45:424-429.
7. Hoffmann J.A., Kafatos F.C., Janeway C.A., Ezekowitz R.A. Phylogenetic perspectives in innate immunity. Science 1999, 284:1313-1318.
8. Underhill D.M., Ozinsky A. Phagocytosis of microbes: complexity in action. Annu Rev Immunol 2002, 20:825-852.
9. Schwarz B.A., Sambandam A., Maillard I., Harman B.C., Love P.E., Bhandoola A. Selective thymus settling regulated by cytokine and chemokine receptors. J Immunol 2007, 178:2008-2017.
10. Zabel B.A., Agace W.W., Campbell J.J., Heath H.M., Parent D., Roberts A.I., et al. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J Exp Med 1999, 190:1241-1256.
11. Papadakis K.A., Prehn J., Nelson V., Cheng L., Binder S.W., Ponath P.D., et al. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. J Immunol 2000, 165:5069-5076.
12. Vicari A.P., Figueroa D.J., Hedrick J.A., Foster J.S., Singh K.P., Menon S., et al. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 1997, 7:291-301.
13. Wurbel M.A., Philippe J.M., Nguyen C., Victorero G., Freeman T., Wooding P., et al. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol 2000, 30:262-271.
14. Hadeiba H., Sato T., Habtezion A., Oderup C., Pan J., Butcher E.C. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol 2008, 9:1253-1260.
15. Wurbel M.A., McIntire M.G., Dwyer P., Fiebiger P. CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis, PLoS One; 6:e16442.
16. Nakamoto N., Ebinuma H., Kanai T., Chu P.S., Ono Y., Mikami Y., et al. CCR9(+) macrophages are required for acute liver inflammation in mouse models of hepatitis. Gastroenterology 2012, 142:366-376.
17. Schmutz C., Cartwright A., Williams H., Haworth O., Williams J.H., Filer A., et al. Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation. Arthritis Res Ther 2010, 12:R161.
18. Kelly-Scumpia K.M., Scumpia P.O., Delano M.J., Weinstein J.S., Cuenca A.G., Wynn J.L., et al. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med 2010, 207:319-326.
19. Hamrick T.S., Havell E.A., Horton J.R., Orndorff P.E. Host and bacterial factors involved in the innate ability of mouse macrophages to eliminate internalized unopsonized Escherichia coli. Infect Immun 2000, 68:125-132.
20. Cohn Z.A. Activation of mononuclear phagocytes: fact, fancy, and future. J Immunol 1978, 121:813-816.
21. Den Otter W., De Groot J.W., Van Basten C.D., Rademakers L.H., De Weger R.A., Pels E. Brewer thioglycollate medium induces different exudates in guinea pigs and mice. Exp Mol Pathol 1982, 36:403-413.
22. Eichner R.D., Smeaton T.C. Agar accumulates in rat peritoneal macrophages elicited with thioglycollate broth. Scand J Immunol 1983, 18:259-263.
23. Spitalny G.L. Dissociation of bactericidal activity from other functions of activated macrophages in exudates induced by thioglycolate medium. Infect Immun 1981, 34:274-284.
24. Ayala A., Herdon C.D., Lehman D.L., Ayala C.A., Chaudry I.H. Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. Blood 1996, 87:4261-4275.
25. Efron P.A., Tinsley K., Minnich D.J., Monterroso V., Wagner J., Lainee P., et al. Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock 2004, 21:566-571.
26. Hotchkiss R.S., Swanson P.E., Freeman B.D., Tinsley K.W., Cobb J.P., Matuschak G.M., et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999, 27:1230-1251.
27. Wesche-Soldato D.E., Swan R.Z., Chung C.S., Ayala A. The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets 2007, 8:493-500.
28. Colonna M., Trinchieri G., Liu Y.J. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004, 5:1219-1226.
29. Papadakis K.A., Prehn J., Moreno S.T., et al. CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. Gastroenterology 2001, 121:246-254.
30. Papadakis K.A., Landers C., Prehn J., et al. CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. J Immunol 2003, 171:159-165.
31. Huys L., Van Hauwermeiren F., Dejager L., Dejonckheere E., Lienenklaus S., Weiss S., et al. Type I interferon drives tumor necrosis factor-induced lethal shock. J Exp Med 2009, 206:1873-1882.
32. Mahieu T., Park J.M., Revets H., Pasche B., Lengeling A., Staelens J., et al. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A 2006, 103:2292-2297.
33. Peck-Palmer O.M., Unsinger J., Chang K.C., Davis C.G., McDunn J.E., Hotchkiss R.S. Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol 2008, 83:1009-1018.
34. Weighardt H., Kaiser-Moore S., Schlautkotter S., Rossmann-Bloeck T., Schleicher U., Bogdan C., et al. Type I IFN modulates host defense and late hyperinflammation in septic peritonitis. J Immunol 2006, 177:5623-5630.