Relating particle formation to salt- and pH-dependent phase separation of non-native aggregates of alpha-chymotrypsinogen A

Journal of Pharmaceutical Sciences

Volumn 101, Issue 10, 2012, Pages 3651-3660

  Kroetsch, Andrew M ^a,b   Sahin, Erinc ^a,b   Wang, Hsiang Yun ^a   Krizman, Sintia ^a   Roberts, Christopher J ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Biotechnology; Microparticles; Physical stability; Protein aggregation; Protein formulation; Solubility

Indexed keywords

ANION; CHYMOTRYPSINOGEN; MONOMER; SODIUM CHLORATE; SODIUM CHLORIDE; THIOCYANATE;

ARTICLE; CONTROLLED STUDY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PARTICLE RESUSPENSION; PH; PHASE SEPARATION; PHASE TRANSITION; SOLUTION AND SOLUBILITY; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84865369923     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23264     Document Type: Article

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