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Volumn 33, Issue 8, 2012, Pages 1572-1580

Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDROXY 3 (3,4 DIHYDROXYPHENYL)PROPIONIC ACID; ANDROGEN RECEPTOR; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT MEDICINAL PRODUCT; POLY[3 (3,4 DIHYDROXYPHENYL)GLYCERIC ACID]; PROPIONIC ACID DERIVATIVE; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

EID: 84865340823     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs202     Document Type: Article
Times cited : (16)

References (43)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics
    • Jemal,A. et al. (2010) Cancer statistics, 2010. CA. Cancer J. Clin., 60, 277-300.
    • (2010) 2010. CA. Cancer J. Clin. , vol.60 , pp. 277-300
    • Jemal, A.1
  • 2
    • 1842612441 scopus 로고    scopus 로고
    • Molecular determinants of resistance to antiandrogen therapy
    • Chen,C.D. et al. (2004) Molecular determinants of resistance to antiandrogen therapy. Nat. Med., 10, 33-39.
    • (2004) Nat. Med. , vol.10 , pp. 33-39
    • Chen, C.D.1
  • 3
    • 0035930133 scopus 로고    scopus 로고
    • Androgen receptor signaling in androgen-refractory prostate cancer
    • Grossmann, M.E. et al. (2001) Androgen receptor signaling in androgen-refractory prostate cancer. J. Natl. Cancer Inst., 93, 1687-1697.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1687-1697
    • Grossmann, M.E.1
  • 4
    • 33646576828 scopus 로고    scopus 로고
    • Androgen receptor as a therapeutic target for androgen independent prostate cancer
    • Sharifi,N. et al. (2006) Androgen receptor as a therapeutic target for androgen independent prostate cancer. Am. J. Ther., 13, 166-170.
    • (2006) Am. J. Ther. , vol.13 , pp. 166-170
    • Sharifi, N.1
  • 5
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan,D. et al. (2000) The hallmarks of cancer. Cell, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1
  • 6
    • 44649155314 scopus 로고    scopus 로고
    • New combination therapies with cell-cycle agents
    • Deep,G. et al. (2008) New combination therapies with cell-cycle agents. Curr. Opin. Investig. Drugs, 9, 591-604.
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 591-604
    • Deep, G.1
  • 7
    • 0028927179 scopus 로고
    • P53, cell cycle control and apoptosis: implications for cancer
    • Kastan,M.B. et al. (1995) P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev., 14, 3-15.
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 3-15
    • Kastan, M.B.1
  • 8
    • 41649104954 scopus 로고    scopus 로고
    • AR, the cell cycle, and prostate cancer
    • Balk,S.P. et al. (2008) AR, the cell cycle, and prostate cancer. Nucl. Recept. Signal., 6, e001.
    • (2008) Nucl. Recept. Signal. , vol.6
    • Balk, S.P.1
  • 9
    • 18044362777 scopus 로고    scopus 로고
    • Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer
    • Liao,X. et al. (2005) Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer. Mol. Cancer Ther., 4, 505-515.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 505-515
    • Liao, X.1
  • 10
    • 79953188414 scopus 로고
    • Isolation and pharmacological investigation of polysaccharides from Symphytum asperum
    • Abuladze,G.V. et al. (1995) Isolation and pharmacological investigation of polysaccharides from Symphytum asperum. Proc. Georg. Acad. Sci. Biol. Series, 21, 129-132.
    • (1995) Proc. Georg. Acad. Sci. Biol. Series , vol.21 , pp. 129-132
    • Abuladze, G.V.1
  • 11
    • 0034856432 scopus 로고    scopus 로고
    • Evaluation of the dietetic and therapeutic potential of a high molecular weight hydroxycinnamate-derived polymer from Symphytum asperum Lepech. Regarding its antioxidant, antilipoperoxidant, antiinflammatory, and cytotoxic properties
    • Barthomeuf,C.M. et al. (2001) Evaluation of the dietetic and therapeutic potential of a high molecular weight hydroxycinnamate-derived polymer from Symphytum asperum Lepech. Regarding its antioxidant, antilipoperoxidant, antiinflammatory, and cytotoxic properties. J. Agric. Food Chem., 49, 3942-3946.
    • (2001) J. Agric. Food Chem. , vol.49 , pp. 3942-3946
    • Barthomeuf, C.M.1
  • 12
    • 84865007070 scopus 로고    scopus 로고
    • Burn healing compositions from Caucasian speceies of Comfrey (Symphytum L)
    • Mulkijanyan,K. et al. (2009) Burn healing compositions from Caucasian speceies of Comfrey (Symphytum L.). Bulletin of the Georgian National Academy of Sciences, 3, 114-117.
    • (2009) Bulletin of the Georgian National Academy of Sciences , vol.3 , pp. 114-117
    • Mulkijanyan, K.1
  • 13
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: an old hypothesis revisited
    • Schäfer,M. et al. (2008) Cancer as an overhealing wound: an old hypothesis revisited. Nat. Rev. Mol. Cell Biol., 9, 628-638.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 628-638
    • Schäfer, M.1
  • 14
    • 33644815806 scopus 로고    scopus 로고
    • Poly[3-(3,4-dihydroxyphenyl)glyceric acid], a new biologically active polymer from Symphytum asperum Lepech. and S. caucasicum Bieb (Boraginaceae)
    • Barbakadze,V. et al. (2005) Poly[3-(3,4-dihydroxyphenyl)glyceric acid], a new biologically active polymer from Symphytum asperum Lepech. and S. caucasicum Bieb. (Boraginaceae). Molecules, 10, 1135-1144.
    • (2005) Molecules , vol.10 , pp. 1135-1144
    • Barbakadze, V.1
  • 15
    • 77956672368 scopus 로고    scopus 로고
    • Effects of Poly[3-(3 4-dihydroxyphenyl) glyceric acid] on the Inflammatory Response of Tumor-Activated Hepatic Sinusoidal Endothelium
    • Barbakadze,V. et al. (2008) Effects of Poly[3-(3,4-dihydroxyphenyl) glyceric acid] on the Inflammatory Response of Tumor-Activated Hepatic Sinusoidal Endothelium. Bulletin of the Georgian National Academy of Sciences, 2, 108-112.
    • (2008) Bulletin of the Georgian National Academy of Sciences , vol.2 , pp. 108-112
    • Barbakadze, V.1
  • 16
    • 0036343915 scopus 로고    scopus 로고
    • Poly[3-(3 4-dihydroxyphenyl)glyceric acid]: a new biologically active polymer from two comfrey species Symphytum asperum and S. caucasicum (Boraginaceae)
    • Barbakadze,V. et al. (2002) Poly[3-(3,4-dihydroxyphenyl)glyceric acid]: a new biologically active polymer from two comfrey species Symphytum asperum and S. caucasicum (Boraginaceae). Russ. J. Bioorg. Chem. 28, 362-330.
    • (2002) Russ. J. Bioorg. Chem. , vol.28 , pp. 362-330
    • Barbakadze, V.1
  • 17
    • 0039012041 scopus 로고    scopus 로고
    • Structure of a new anticomplementary dihydroxycinnamate-derived polymer from Symphytum asperum (Boraginaceae)
    • Barbakadze,V. et al. (2000) Structure of a new anticomplementary dihydroxycinnamate-derived polymer from Symphytum asperum (Boraginaceae). Mendeleev Communications, 10, 148-149.
    • (2000) Mendeleev Communications , vol.10 , pp. 148-149
    • Barbakadze, V.1
  • 18
    • 77955143084 scopus 로고    scopus 로고
    • Enantioselective synthesis and antioxidant activity of 3-(3 4-dihydroxyphenyl)-glyceric acid-basic monomeric moiety of a biologically active polyether from Symphytum asperum and S. caucasicum
    • Merlani,M. et al. (2010) Enantioselective synthesis and antioxidant activity of 3-(3,4-dihydroxyphenyl)-glyceric acid-basic monomeric moiety of a biologically active polyether from Symphytum asperum and S. caucasicum. Chirality, 22, 717-725.
    • (2010) Chirality , vol.22 , pp. 717-725
    • Merlani, M.1
  • 19
    • 68149099008 scopus 로고    scopus 로고
    • Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice
    • Kaur,M. et al. (2009) Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice. Pharm. Res., 26, 2133-2140.
    • (2009) Pharm. Res. , vol.26 , pp. 2133-2140
    • Kaur, M.1
  • 20
    • 55949101361 scopus 로고    scopus 로고
    • Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells
    • Kaur,M. et al. (2008) Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. Nutr. Cancer, 60 Suppl 1, 2-11.
    • (2008) Nutr. Cancer , vol.60 , Issue.SUPPL. 1 , pp. 2-11
    • Kaur, M.1
  • 21
    • 5344230113 scopus 로고    scopus 로고
    • Trefoil factor 3 overexpression in prostatic carcinoma: prognostic importance using tissue microarrays
    • Faith,D.A. et al. (2004) Trefoil factor 3 overexpression in prostatic carcinoma: prognostic importance using tissue microarrays. Prostate, 61, 215-227.
    • (2004) Prostate , vol.61 , pp. 215-227
    • Faith, D.A.1
  • 22
    • 11144222544 scopus 로고    scopus 로고
    • Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance
    • Singh,R.P. et al. (2004) Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance. Clin. Cancer Res., 10, 8641-8647.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 8641-8647
    • Singh, R.P.1
  • 23
    • 24944505715 scopus 로고    scopus 로고
    • Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin
    • Gu,M. et al. (2005) Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis, 26, 1404-1413.
    • (2005) Carcinogenesis , vol.26 , pp. 1404-1413
    • Gu, M.1
  • 24
    • 34250310422 scopus 로고    scopus 로고
    • A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells
    • Li,T.H. et al. (2007) A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells. Nucleic Acids Res., 35, 2767-2776.
    • (2007) Nucleic Acids Res , vol.35 , pp. 2767-2776
    • Li, T.H.1
  • 25
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal,B.B. et al. (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol., 71, 1397-1421.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1
  • 26
    • 77957598340 scopus 로고    scopus 로고
    • Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer
    • Deep, G. et al. (2010) Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev., 29, 447-463.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 447-463
    • Deep, G.1
  • 27
    • 77956016499 scopus 로고    scopus 로고
    • Cancer prevention with natural compounds
    • Gullett,N.P. et al. (2010) Cancer prevention with natural compounds. Semin. Oncol., 37, 258-281.
    • (2010) Semin. Oncol. , vol.37 , pp. 258-281
    • Gullett, N.P.1
  • 28
    • 52049109838 scopus 로고    scopus 로고
    • Natural products in drug discovery
    • Harvey,A.L. (2008) Natural products in drug discovery. Drug Discov. Today, 13, 894-901.
    • (2008) Drug Discov. Today , vol.13 , pp. 894-901
    • Harvey, A.L.1
  • 29
    • 5144224381 scopus 로고    scopus 로고
    • A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer
    • Singh,R.P. et al. (2004) A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutat. Res., 555, 21-32.
    • (2004) Mutat. Res. , vol.555 , pp. 21-32
    • Singh, R.P.1
  • 30
    • 27144476777 scopus 로고    scopus 로고
    • Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study
    • Predel,H.G. et al. (2005) Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study. Phytomedicine, 12, 707-714.
    • (2005) Phytomedicine , vol.12 , pp. 707-714
    • Predel, H.G.1
  • 31
    • 33751270698 scopus 로고    scopus 로고
    • Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression
    • Cheng,H. et al. (2006) Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression. Cancer Res., 66, 10613-10620.
    • (2006) Cancer Res , vol.66 , pp. 10613-10620
    • Cheng, H.1
  • 32
    • 85047697645 scopus 로고    scopus 로고
    • Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor
    • Eder,I.E. et al. (2002) Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor. Cancer Gene Ther., 9, 117-125.
    • (2002) Cancer Gene Ther , vol.9 , pp. 117-125
    • Eder, I.E.1
  • 33
    • 0142125911 scopus 로고    scopus 로고
    • Hsp90 as a therapeutic target in prostate cancer
    • Solit,D.B. et al. (2003) Hsp90 as a therapeutic target in prostate cancer. Semin. Oncol., 30, 709-716.
    • (2003) Semin. Oncol. , vol.30 , pp. 709-716
    • Solit, D.B.1
  • 34
    • 0036091221 scopus 로고    scopus 로고
    • 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
    • Solit,D.B. et al. (2002) 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin. Cancer Res., 8, 986-993.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 986-993
    • Solit, D.B.1
  • 35
    • 0036170838 scopus 로고    scopus 로고
    • Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells
    • Zegarra-Moro,O.L. et al. (2002) Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res., 62, 1008-1013.
    • (2002) Cancer Res , vol.62 , pp. 1008-1013
    • Zegarra-Moro, O.L.1
  • 36
    • 4944246790 scopus 로고    scopus 로고
    • Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer
    • Scher,H.I. et al. (2004) Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer. Endocr. Relat. Cancer, 11, 459-476.
    • (2004) Endocr. Relat. Cancer , vol.11 , pp. 459-476
    • Scher, H.I.1
  • 37
    • 23144434218 scopus 로고    scopus 로고
    • Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells
    • Hååg,P. et al. (2005) Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. J. Steroid Biochem. Mol. Biol., 96, 251-258.
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.96 , pp. 251-258
    • Hååg, P.1
  • 38
    • 0032493489 scopus 로고    scopus 로고
    • Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells
    • Knudsen,K.E. et al. (1998) Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells. J. Biol. Chem., 273, 20213-20222.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20213-20222
    • Knudsen, K.E.1
  • 39
    • 0344034639 scopus 로고    scopus 로고
    • Effects of blocking androgen receptor expression with specific hammerhead ribozyme on in vitro growth of prostate cancer cell line
    • Tong,Q. et al. (2003) Effects of blocking androgen receptor expression with specific hammerhead ribozyme on in vitro growth of prostate cancer cell line. Chin. Med. J., 116, 1515-1518.
    • (2003) Chin. Med. J. , vol.116 , pp. 1515-1518
    • Tong, Q.1
  • 40
    • 0033520806 scopus 로고    scopus 로고
    • Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence
    • Agus,D.B. et al. (1999) Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence. J. Natl. Cancer Inst., 91, 1869-1876.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1869-1876
    • Agus, D.B.1
  • 41
    • 0035887451 scopus 로고    scopus 로고
    • Overexpressed androgen receptor linked to p21WAF1 silencing may be responsible for androgen independence and resistance to apoptosis of a prostate cancer cell line
    • Wang,L.G. et al. (2001) Overexpressed androgen receptor linked to p21WAF1 silencing may be responsible for androgen independence and resistance to apoptosis of a prostate cancer cell line. Cancer Res., 61, 7544-7551.
    • (2001) Cancer Res , vol.61 , pp. 7544-7551
    • Wang, L.G.1
  • 42
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman,B.J. et al. (2001) The development of androgen-independent prostate cancer. Nat. Rev. Cancer, 1, 34-45.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1
  • 43
    • 0015781790 scopus 로고
    • Deletion of cells by apoptosis during castration-induced involution of the rat prostate
    • Kerr,J.F. et al. (1973) Deletion of cells by apoptosis during castration-induced involution of the rat prostate. Virchows Arch. B. Cell Pathol., 13, 87-102.
    • (1973) Virchows Arch. B. Cell Pathol. , vol.13 , pp. 87-102
    • Kerr, J.F.1


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