Blood flow and associated pathophysiology of uterine cervix cancers: Characterisation and relevance for localised hyperthermia

International Journal of Hyperthermia

Volumn 28, Issue 6, 2012, Pages 518-527

  Vaupel, Peter W ^a   Kelleher, Debra K ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Blood flow; Cervical cancer; Hypoxia; Interstitial hypertension; Oxygenation status

Indexed keywords

GLUCOSE; LACTIC ACID;

ACIDOSIS; ARTICLE; CANCER CELL; HEAT SENSITIVITY; HEATING; HUMAN; HYPERTHERMIC THERAPY; HYPOXIA; PATHOPHYSIOLOGY; TISSUE OXYGENATION; TISSUE PRESSURE; TUMOR BLOOD FLOW; TUMOR MICROENVIRONMENT; UTERINE CERVIX CANCER;

ANIMALS; ANOXIA; CERVIX UTERI; FEMALE; GLUCOSE; HUMANS; HYPERTHERMIA, INDUCED; LACTIC ACID; UTERINE CERVICAL NEOPLASMS;

EID: 84865333847     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.3109/02656736.2012.699134     Document Type: Article

References (76)

1. Horsman MR. Tissue physiology and the response to heat. Int J Hyperthermia 2006;22:197-203. (Pubitemid 43878679)
2. Vaupel PW, Kelleher DK. Pathophysiological and vascular characteristics of tumours and their importance for hyperthermia: Heterogeneity is the key issue. Int J Hyperthermia 2010;26:211-223.
3. Vaupel P, Horsman MR. Tumour perfusion and associated physiology: Characterization and significance for hyperthermia. Int J Hyperthermia 2010;26:209-210.
4. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 1989;49:6449-6465. (Pubitemid 20008770)
5. Hokland SL, Nielsen T, Busk M, Horsman MR. Imaging tumour physiology and vasculature to predict and assess response to heat. Int J Hyperthermia 2010;26:264-272.
6. Lewis BV. Uterine blood flow. Review. Obstet Gyn Survey 1969;24:1211-1233.
7. Molls M, Feldmann HJ. Clinical investigations of blood flow in malignant tumors of the pelvis and the abdomen in patients undergoing thermoradiotherapy. Funktionsanalyse biolog Systeme 1991;20:143-153.
8. Lyng H, Vorren AO, Sundfor K, Taksdal I, Lien HH, Kaalhus O, et al. Intra- and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy. Int J Cancer 2001;96:182-190. (Pubitemid 32520673)
9. Haider MA, Milosevic M, Fyles A, Sitartchouk I, Yeung I, Henderson E, et al. Assessment of the tumor microenvironment in cervix cancer using dynamic contrast enhanced CT, interstitial fluid pressure and oxygen measurements. Int J Radiat Oncol Biol Phys 2005;62:1100-1107. (Pubitemid 40884424)
10. Shibuya K, Tsushima Y, Horisoko E, Noda S, Taketomi- Takahashi A, Ohno T, et al. Blood flow change quantification in cervical cancer before and during radiation therapy using perfusion CT. J Radiat Res 2011;52:804-811.
11. Lüdemann L, Sreenivasa G, Amthauer H, Michel R, Gellermann J, Wust P. Use of H2 15O-PET for investigating perfusion changes in pelvic tumors due to regional hyperthermia. Int J Hyperthermia 2009;25:299-308.
12. Hawighorst H, Knapstein PG, Weikel W, Knopp MV, Zuna I, Knof A, et al. Angiogenesis of uterine cervical carcinoma: Characterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement. Cancer Res 1997;57: 4777-4786. (Pubitemid 27468984)
13. Hawighorst H, Knapstein PG, Knopp MV, Weikel W, Brix G, Zuna I, et al. Uterine cervical carcinoma: Comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival. Cancer Res 1998;58:3598-3602. (Pubitemid 28376557)
14. Ott OJ, Issels RD, Wessalowski R. Hyperthermia in Oncology - Principles and Therapeutic Outlook. Bremen, London, Boston: Uni-Med Science, 2010.
15. Bayer C, Shi K, Astner ST, Maftei C-A, Vaupel P. Acute versus chronic hypoxia: Why a simplified classification is simply not enough. Int J Radiat Oncol Biol Phys 2011;80:965-968.
16. Vaupel P, Harrison L. Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response. Oncologist 2004;9S5:4-9. (Pubitemid 39658340)
17. Höckel M, Vaupel P. Tumor hypoxia: Definitions and current clinical, biologic and molecular aspects. J Natl Cancer Inst 2001;93:266-276. (Pubitemid 32219813)
18. Vaupel P, Mayer A. Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev 2007;26:225-239. (Pubitemid 47101660)
19. Höckel M, Knoop C, Schlenger K, Vorndran B, Baussmann E, Mitze M, et al. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 1993;26:45-50. (Pubitemid 23063609)
20. Höckel M, Schlenger K, Aral B, Mitze M, Schäffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56:4509-4515. (Pubitemid 26330463)
21. Kolstad P. Vascularization, Oxygen Tension, and Radiocurability in Cancer of the Cervix. Oslo: Universitetsvorlaget, 1964.
22. Kolstad P. Intercapillary distance, oxygen tension and local recurrence in cervix cancer. Scand J Clin Lab Invest Suppl 1968;106:145-157.
23. Bergsjö P, Evans JC. Oxygen tension of cervical carcinoma during the early phase of external irradiation. I. Measurements with a Clark micro electrode. Scand J Clin Lab Invest Suppl 1969;106:159-166.
24. Bergsjö P, Evans JC. Oxygen tension of cervical carcinoma during the early phase of external irradiation. II. Measurements with bare platinum micro electrodes. Scand J Clin Lab Invest 1971;27:71-82.
25. Kallinowski F, Zander R, Hoeckel M, Vaupel P. Tumor tissue oxygenation as evaluated by computerized-pO2-histography. Int J Radiat Oncol Biol Phys 1990;19:953-961. (Pubitemid 20345165)
26. Höckel M, Schlenger K, Knoop C, Vaupel P. Oxygenation of carcinomas of the uterine cervix: Evaluation of computerized O2 tension measurements. Cancer Res 1991;51:6098-6102.
27. Vaupel P, Höckel M, Mayer A. Detection and characterization of tumor hypoxia using pO2 histography. Antioxid Redox Signal 2007;9:1221-1235. (Pubitemid 47080831)
28. Lim K, Chan P, Dinniwell R, Fyles A, Haider M, Cho Y-B, et al. Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: Radiobiologic modeling and correlation with tumor hypoxia. Int J Radiat Oncol Biol Phys 2008;70:126-133. (Pubitemid 350251038)
29. Nakano T, Suzuki Y, Ohno T, Kato S, Suzuki M, Morita S, et al. Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia. Clin Cancer Res 2006;12:2185-2190.
30. Sakata K, Someya M, Nagakura H, Nakata K, Oouchi A, Hareyama M, et al. A clinical study of hypoxia using endogenous hypoxic markers and polarographic oxygen electrodes. Strahlenther Onkol 2006;182:511-517. (Pubitemid 44316239)
31. Hoeckel M, Kahn T, Einenkel J, Manthey N, Braumann U-D, Hildebrandt G, et al. Local spread of cervical cancer revisited: A clinical and pathological pattern analysis. Gynecol Oncol 2010;117:401-408.
32. Höckel M, Schlenger K, Höckel S, Aral B, Schäffer U, Vaupel P. Tumor hypoxia in pelvic recurrences of cervical cancer. Int J Cancer 1998;79:365-369. (Pubitemid 28359734)
33. Holland JP, Lewis JS, Dehdashti F. Assessing tumor hypoxia by positron emission tomography with Cu-ATSM. J Nucl Med Mol Imaging 2009;53:193-200.
34. Mees G, Dierckx R, Vangestel C, van de Wiele C. Molecular imaging of hypoxia with radiolabelled agents. Eur J Nucl Med Mol Imaging 2009;36:1674-1686.
35. Dewhirst MW, Thrall DE, Palmer G, Schroeder T, Vujaskovic Z, Charles HC, et al. Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy. Int J Hyperthermia 2010;26:283-293.
36. Padhani AR, Krohn KA, Lewis JS, Alber M. Imaging oxygenation of human tumours. Eur Radiol 2007;17: 861-872. (Pubitemid 46772763)
37. Chitneni SK, Palmer GM, Zalutsky MR, Dewhirst MW. Molecular imaging of hypoxia. J Nucl Med 2011;52: 165-168.
38. Dehdashti F, Grigsby PW, Lewis JS, Laforest R, Siegel BA, Welch MJ. Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med 2008;49:201-205. (Pubitemid 351225657)
39. Lewis JS, Laforest R, Dehdashti F, Grigsby PW, Welch MJ, Siegel BA. An imaging comparison of 64Cu-ATSM and 60CU-ATSM in cancer of the uterine cervix. J Nucl Med 2008;49:1177-1182. (Pubitemid 351948028)
40. Nordsmark M, Loncaster J, Aquino-Parsons C, Chou S-C, Gebski V, West C, et al. The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: A prospective international multi-center study. Radiother Oncol 2006;80:123-131. (Pubitemid 44314011)
41. Jankovic B, Aquino-Parsons C, Raleigh JA, Stanbridge EJ, Durand RE, Banath JP, et al. Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix. Cytometry Part B (Clinical Cytometry) 2006;70B: 45-55.
42. Harima Y, Togashi A, Horikoshi K, Imamura M, Sougawa M, Sawada S, et al. Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis. Int J Radiat Oncol Biol Phys 2004;60:237-248. (Pubitemid 39165491)
43. Guyton AC, Hall JE. Textbook of Medical Physiology, 11th edn. Philadelphia: Elsevier; 2006.
44. Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, et al. Interstitial hypertension in head and neck tumors in patients: Correlation with tumor size. Cancer Res 1992;52:1993-1995.
45. Milosevic MF, Fyles AW, Wong R, Pintilie M, Kavanagh M-C, Levin W, et al. Interstitial fluid pressure in cervical carcinoma: Within tumor heterogeneity, and relation to oxygen tension. Cancer 1998;82:2418-2426. (Pubitemid 28283449)
46. Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK. Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response. Cancer Res 1991;51: 6695-6698.
47. Milosevic M, Fyles A, Hedley D, Pintilie M, Levin W, Manchul L, et al. Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res 2001;61:6400-6405. (Pubitemid 32783245)
48. Fyles A, Milosevic M, Pintilie M, Syed A, Levin W, Manchul L, et al. Long-term performance of interstitial fluid pressure and hypoxia as prognostic factors in cervix cancer. Radiother Oncol 2006;80:132-137. (Pubitemid 44314013)
49. Yeo S-G, Kim J-S, Cho M-J, Kim K-H, Kim J-S. Interstitial fluid pressure as a prognostic factor in cervical cancer following radiation therapy. Clin Cancer Res 2009;15: 6201-6207.
50. Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, et al. Interstitial fluid pressure in solid tumors following hyperthermia: Possible correlation with therapeutic response. Cancer Res 1992;52:487-490.
51. Hauck ML, Coffin DO, Dodge RK, Dewhirst MW, Mitchell JB, Zalusky MR. A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft does not affect tumour interstitial fluid pressure. Int J Hyperthermia 1997;13:307-316. (Pubitemid 27296609)
52. Gerweck LE. Modifiers of thermal effects: Environmental factors. In: Urano M, Douple E, editors. Hyperthermia and Oncology. Volume 1. Utrecht: VSP; 1988. pp. 83-98.
53. Vaupel P, Okunieff P, Neuringer LJ. In vivo 31P-NMR spectroscopy of murine tumours before and after localized hyperthermia. Int J Hyperthermia 1990;6:15-31. (Pubitemid 20082649)
54. Vaupel P, Kelleher DK. Metabolic status and reaction to heat of normal and tumor tissue. In: Seegenschmiedt MH, Fessenden P, and Vernon CC, editors. Thermoradiotherapy and Thermochemotherapy. Vol. 1. Berlin, Heidelberg, New York: Springer; 1995. pp. 157-176.
55. Song CW. Effect of local hyperthermia on blood flow and microenvironment. Cancer Res 1984;44:4721s-4730s. (Pubitemid 14000088)
56. Lora-Michiels M, Yu D, Sanders L, Poulson JM, Azuma C, Case B, et al. Extracellular pH and 31P magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clin Cancer Res 2006;12:5733-5740. (Pubitemid 44629603)
57. Mueller-Klieser W, Vaupel P, Streffer C. Energy status of malignant tumors in patients and experimental animals. In: Molls M and Vaupel P, editors. Blood perfusion and microenvironment of human tumors. Berlin, Heidelberg, New York: Springer; 2000. pp. 121-132.
58. Kidd EA, Grigsby PW. Intratumoral metabolic heterogeneity of cervical cancer. Clin Cancer Res 2008;14:5236-5241.
59. Schaefer C, Mayer W-K, Krü ger W, Vaupel P. Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon local hyperthermia and/or hyperglycaemia. J Cancer Res Clin Oncol 1993;119:599-608. (Pubitemid 23221036)
60. Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 2008;118:3930-3942.
61. Schwickert G, Walenta S, Sundfor K, Rofstad EK, Mueller- Klieser W. Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 1995;55:4757-4759.
62. Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000;60:916-921. (Pubitemid 30129526)
63. Walenta S, Mueller-Klieser WF. Lactate: Mirror and motor of tumor malignancy. Semin Radiat Oncol 2004;14:267-274. (Pubitemid 38903231)
64. Vaupel P. Physiological properties of malignant tumours. NMR Biomed 1992;5:220-225.
65. Vaupel P. Pathophysiology of solid tumors. In: Molls M, Vaupel P, Nieder C, and Anscher MS, editors. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. Berlin, Heidelberg, New York: Springer; 2009. pp. 51-92.
66. Vaupel P, Kelleher DK, Engel T. Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour. Br J Cancer 1994;69:46-49. (Pubitemid 24021821)
67. Gerweck LE, Urano M, Koutcher J, Fellenz MP, Kahn J. Relationship between energy status, hypoxic cell fraction, and hyperthermic sensitivity in a murine fibrosarcoma. Radiat Res 1989;117:448-458,76.
68. Gerweck LE, Dahlberg WK, Epstein LF, Shimm D. Influence of nutrient and energy deprivation on cellular response to single and fractionated heat treatments. Radiat Res 1984;99:573-581. (Pubitemid 14031871)
69. Ohtsubo T, Saito H, Tanaka N, Kano E. Application of the ATP-bioluminescence assay to thermosensitivity testing for head and neck cancer. Eur Arch Oto-Rhino-Laryngol 1996;253:278-282. (Pubitemid 26164439)
70. Koutcher JA, Barnett D, Kornblith AB, Cowburn D, Brady TJ, Gerweck LE. Relationship of changes in pH and energy status to hypoxic cell fraction and hyperthermia sensitivity. Int J Radiat Oncol Biol Phys 1990;18:1429-1435. (Pubitemid 20234156)
71. Vaupel P. Pathophysiological mechanisms of hyperthermia in cancer therapy. In: Gautherie M, editor. Biological Basis of Oncologic Thermotherapy. Berlin, Heidelberg, New York: Springer; 1990. pp. 73-134.
72. Prescott DM, Charles HC, Sostman HD, Dodge RK, Thrall DE, Page RL, et al. Therapy monitoring in human and canine soft-tissue sarcomas using magnetic resonance imaging and spectroscopy. Int J Radiat Oncol Biol Phys 1994;28:415-423. (Pubitemid 24020526)
73. Sijens PE, Bovee WMMJ, Koole P, Schipper J. Phosphorus NMR study of the response of a murine tumour to hyperthermia as a function of treatment time and temperature. Int J Hyperthermia 1989;5:351-357. (Pubitemid 19091241)
74. Dewhirst MW, Poulson JM, Yu D, Sanders L, Lora- Michiels M, Vujaskovic Z, et al. Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy. Int J Radiat Oncol Biol Phys 2005;61:480-491. (Pubitemid 40164445)
75. van der Zee J, Gonzàlez Gonzàlez D, van Rhoon GC, van Dijk JDP, van Putten WLJ, Hart AAM. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: A prospective, randomised, multicentre trial. Lancet 2000;355:1119-1125. (Pubitemid 30172932)
76. Franckena M, Stalpers LJ, Koper PC, Wiggenraad RG, Hoogenraad WJ, van Dijk JD, et al. Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: An update of the Dutch Deep Hyperthermia Trial. Int J Radiat Oncol Biol Phys 2008;70:1176-1182. (Pubitemid 351296102)