PIM-1 kinase expression in adipocytic neoplasms: Diagnostic and biological implications

International Journal of Experimental Pathology

Volumn 91, Issue 1, 2010, Pages 34-43

  Nga, Min En ^a   Swe, Nu Nu Ma ^a   Chen, Kang Ting ^a   Shen, Liang ^a   Lilly, Michael B ^b   Chan, Siew Pang ^c   Salto Tellez, Manuel ^a   Das, Kakoli ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c TAN TOCK SENG HOSPITAL   (Singapore)

Author keywords

Adipocytic neoplasms; Immunohistochemistry; Myxoid liposarcoma; PIM 1; Sarcomas; Tissue microarray

Indexed keywords

EOSIN; HEMATOXYLIN; LIPID; PROTEIN; PROTEIN KINASE PIM 1;

ANGIOLIPOMA; ARTICLE; BENIGN TUMOR; CELL VACUOLE; CHONDROSARCOMA; CHORDOMA; CYTOPLASM; DERMATOFIBROMA; DISEASE MARKER; GENE EXPRESSION; HIBERNOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPOBLASTOMA; LIPOMA; LIPOSARCOMA; MYXOMA; MYXOSARCOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; TECHNOLOGY; TISSUE MICROARRAY; TISSUE SECTION;

ADIPOCYTES; CELL DIFFERENTIATION; DIAGNOSIS, DIFFERENTIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASMS, ADIPOSE TISSUE; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; PROTO-ONCOGENE PROTEINS C-PIM-1; RNA, MESSENGER; SARCOMA; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; VACUOLES;

EID: 74549183449     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2009.00673.x     Document Type: Article

References (40)

1. 112 gatekeeper site. FEBS Lett. 571, 43 49.
2. Amson R., Sigaux F., Przedborski S. et al. (1989) The human proto-oncogene product p33 pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc. Natl. Acad. Sci. USA 86, 8857 8861.
3. Antonescu C.R. (2006) The role of genetic testing in soft tissue sarcoma. Histopathology 48, 13 21.
4. Antonescu C.R., Tschernyavsky S.J., Decuseara R. et al. (2001) Prognostic impact of p53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinico-pathologic study of 82 cases. Clin. Cancer Res. 7, 3977 3987.
5. Bachmann M., Hennemann H., Xing P.X., Hoffmann I., Moroy T. (2004) The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (CTAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J. Biol. Chem. 279, 48319 48328.
6. Baird K., Davis S., Antonescu C.R. et al. (2005) Gene expression profiling of human sarcomas: insights into sarcoma biology. Cancer Res. 65, 9226 9235.
7. Berns A., Breuer M., Verbeek S. et al. (1989) Transgenic mice as a means to study synergism between oncogenes. Int. J. Cancer 4, 22 25.
8. Borden E.C., Baker L.H., Bell R.S. et al. (2003) Soft tissue sarcomas of the adults: state of the translational science. Clin. Cancer Res. 9, 1941 1956.
9. Chen X.P., Losman J.A., Cowan S. et al. (2002) Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc. Natl. Acad. Sci. USA 99, 2175 2180.
10. Cibull T.L., Jones T.D., Li L. et al. (2006) Overexpression of PIM-1 during progression of prostatic adenocarcinoma. J. Clin. Pathol. 59, 285 288.
11. Coindre J.M. (2003) Immunohistochemistry in the diagnosis of soft tissue tumours. Histopathology 43, 1 16.
12. Coindre J.M., Terrier P., Bui N.B. et al. (1996) Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J. Clin. Oncol. 14, 869 877.
13. Coindre J.M., Pelmus M., Hostein I. et al. (2003) Should molecular testing be required for diagnosing synovial sarcoma: a prospective study of 204 cases. Cancer 98, 2700 2707.
14. Cormier J.N. Pollock R.E. (2004) Soft tissue tumours. CA Cancer J. Clin. 54, 94 109.
15. Cuypers H.T., Selten G., Quint W. et al. (1986) Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell 37, 141 150.
16. Dreyfus F., Sola B., Fichelson S. et al. (1990) Rearrangements of the Pim-1, c-myc and p53 genes in Friend helper virus-induced mouse erythroleukemias. Leukemia 4, 590 594.
17. Folpe A.L., Goldblum J.R., Rubin B.P. et al. (2005) Morphologic and immunophenotypic diversity in Ewing family tumours: a study of 66 genetically confirmed cases. Am. J. Surg. Pathol. 29, 1025 1033.
18. Gapter L.A., Magnuson N.S., Ng K.Y. et al. (2006) Pim-1 kinase expression during murine mammary development. Biochem. Biophys. Res. Commun. 345, 989 997.
19. Ginsberg J.P., de Alava E., Ladanyi M. et al. (1999) EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. J. Clin. Oncol. 17, 1809 1814.
20. Goffman T., Tochner Z., Glatstein E. (1991) Primary treatment of large and massive adult sarcomas with iododeoxyuridine and aggressive hyperfractionated irradiation. Cancer 67, 572 576.
21. Kelly K.M., Womer R.B., Sorensen P.H. et al. (1997) Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. J. Clin. Oncol. 15, 1831 1836.
22. Koike N., Maita H., Taira T., Ariga H., Iguchi-Ariga S.M. (2000) Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1 (1). FEBS Lett. 467, 17 21.
23. Kumar A., Mandiyan V., Suzuki Y. et al. (2005) Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J. Mol. Biol. 348, 183 193.
24. van Lohuizen M., Verbeek S., Krimpenfort P. et al. (1989) Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc murine leukemia virus-induced tumours. Cell 56, 673 682.
25. Mochizuki T., Kitanaka C., Noguchi K., Muramatsu T., Asai A., Kuchino Y. (1999) Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1- mediated activation of the c-Myc signaling pathway. J. Biol. Chem. 274, 18659 18666.
26. Pasqualucci L., Neumeister P., Goossens T. et al. (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412, 341 346.
27. Salto-Tellez M., Lee S.C., Chiu L.L. et al. (2004) Microsatellite instability in colorectal cancer - considerations for molecular diagnosis and high-throughput screening of archival tissues. Clin. Chem. 50, 1082 1086.
28. Salto-Tellez M., Nga M.E., Han H.C. et al. (2007) Molecular information arrays characterizes the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours. Br. J. Cancer 98, 776 782.
29. Sandberg A.A. Bridge J.A. (2002) Updates on the cytogenetics and molecular genetics of bone and soft tissue tumours: synovial sarcoma. Cancer Genet. Cytogenet. 133, 1 23.
30. Shah N., Pang B., Yeoh K.G. et al. (2008) Potential roles for the Pim-1 kinase in human cancer - a molecular and therapeutic appraisal. Eur. J. Cancer 44, 2144 2151.
31. Verbeek S., van Lohuizen M., van der Valk M. et al. (1991) Mice bearing the Eμ-myc and Eμ-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol. Cell. Biol. 11, 1176 1179.
32. Wang Z., Bhattacharya N., Weaver M. et al. (2001) A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumourigenesis. J. Vet. Sci. 2, 167 179.
33. Wang Z., Bhattacharya N., Mixter P.F., Wei W., Sedivy J., Magnuson N.S. (2002) Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochim. Biophys. Acta 1593, 45 55.
34. Weiss S.W. Goldblum J.R. (2007) Immunohistochemistry for analysis of soft tissue tumours. In : Weiss Enzinger and Weiss's Soft Tissue Tumours, pp. 129 174 (eds A.L. Folpe, A.M. Gown 5th edn, Philadelphia, PA : Mosby Elsevier.
35. West R.B. van de Rijn M. (2006) The role of microarray technologies in the study of soft tissue tumours. Histopathology 48, 22 31.
36. Xia S.J. Barr F.G. (2005) Chromosome translocations in sarcomas and the emergence of oncogenic transcription factors. Eur. J. Cancer 41, 2513 2527.
37. Xie Y., Xu K., Dai B. et al. (2006) The 44 kDa PIM-1 kinase directly interacts with tyrosine kinase EtklBMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. Oncogene 25, 70 78.
38. Xu Y., Zhang T., Tang H. et al. (2005) Overexpression of Pim-1 is a potential biomarker in prostate carcinoma. J. Surg. Oncol. 92, 326 330.
39. Yan B., Zemskova M., Holder S. et al. (2003) The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J. Biol. Chem. 278, 45358 45367.
40. Zippo A., De Robertis A., Bardelli M., Galvagni F., Oliviero S. (2004) Identification of Flk-1 target genes in vasculogenesis: PIM1 is required for endothelial and mural cell differentiation in vitro. Blood 103, 4536 4544.