In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 364-372

  Abbah, Sunny Akogwu ^a   Liu, Jing ^a   Lam, Raymond W M ^a   Goh, James C H ^b   Wong, Hee Kit ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Controlled release; Core shell structure; Polyelectrolyte complexes; Recombinant human bone morphogenetic protein 2 (rhBMP 2); Spinal fusion

Indexed keywords

CONTROLLED RELEASE; CORE SHELL STRUCTURE; POLYELECTROLYTE COMPLEXES; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (RHBMP-2); SPINAL FUSION;

AMINO ACIDS; BIOMECHANICS; BONE; LOADING; POLYELECTROLYTES; POLYSACCHARIDES; TISSUE ENGINEERING;

SHELLS (STRUCTURES);

ALGINIC ACID; POLYELECTROLYTE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; DRUG ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINE FUSION; TISSUE ENGINEERING;

ALGINATES; ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL LINE; CELL SURVIVAL; DEAE-DEXTRAN; DRUG CARRIERS; GLUCURONIC ACID; HEPARIN; HEXURONIC ACIDS; MALE; MICE; MICROSPHERES; OSTEOGENESIS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SPINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 84865324991     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.027     Document Type: Article

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