A [polycation:heparin] complex releases growth factors with enhanced bioactivity

Journal of Controlled Release

Volumn 150, Issue 2, 2011, Pages 157-163

  Chu, Hunghao ^a   Johnson, Noah Ray ^a   Mason, Neale Scott ^b   Wang, Yadong ^a  

^a MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Controlled release; Delivery vehicle; Growth factors; Heparin; Self assembly

Indexed keywords

CELL FUNCTIONS; CONTROLLED DELIVERY; CONTROLLED RELEASE; DELIVERY VEHICLE; GROWTH FACTOR; GROWTH FACTOR DELIVERY; GROWTH FACTORS; HEPARIN; HEPARIN BINDING; HIGH EFFICIENCY; MATRIX; POLYCATIONS; REGENERATIVE MEDICINE; SELF RENEWAL;

ETHYLENE; PEPTIDES; POLYSACCHARIDES; SELF ASSEMBLY; VEHICLES;

BIOACTIVITY;

FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; HEPARIN; NERVE GROWTH FACTOR; POLY(ETHYLENE ARGININYLASPARTATE DIGLYCERIDE); POLYCATION; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG PROTEIN BINDING; DRUG RELEASE; DRUG SYNTHESIS; PRIORITY JOURNAL; ZETA POTENTIAL;

ANIMALS; ARGININE; ASPARTIC ACID; AZO COMPOUNDS; BENZENESULFONATES; BIOLOGICAL AVAILABILITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; EPOXY RESINS; FIBROBLAST GROWTH FACTOR 2; HEPARIN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGHT; METHYLENE BLUE; MICROSCOPY, ELECTRON, SCANNING; NERVE GROWTH FACTOR; NEURONS; PARTICLE SIZE; PC12 CELLS; POLYAMINES; POLYETHYLENES; RATS; SCATTERING, RADIATION; STATIC ELECTRICITY;

EID: 79952993890     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.11.025     Document Type: Article

References (30)

1. J. Taipale, and J. KeskiOja Growth factors in the extracellular matrix FASEB J. 11 1997 51 59 (Pubitemid 27076324)
2. L. Macri, D. Silverstein, and R.A.F. Clark Growth factor binding to the pericellular matrix and its importance in tissue engineering Adv. Drug Deliv. Rev. 59 2007 1366 1381 (Pubitemid 350090013)
3. L. Uebersax, H.P. Merkle, and L. Meinel Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems Tissue Eng. B Rev. 15 2009 263 289
4. J.M. Whitelock, A.D. Murdoch, R.V. Iozzo, and P.A. Underwood The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases J. Biol. Chem. 271 1996 10079 10086 (Pubitemid 26131567)
5. R. Raman, V. Sasisekharan, and R. Sasisekharan Structural insights into biological roles of protein-glycosaminoglycan interactions Chem. Biol. 12 2005 267 277 (Pubitemid 40406273)
6. J.T. Gallagher, and J.E. Turnbull Heparin-sulfate in the binding and activation of basic fibroblast growth-factor Glycobiology 2 1992 523 528 (Pubitemid 23004382)
7. J.M. Whitelock, J. Melrose, and R.V. Iozzo Diverse cell signaling events modulated by perlecan Biochemistry 47 2008 11174 11183
8. O. Saksela, D. Moscatelli, A. Sommer, and D. Rifkin Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation J. Cell Biol. 107 1988 743 751
9. J. Kreuger, D. Spillmann, J.P. Li, and U. Lindahl Interactions between heparan sulfate and proteins: the concept of specificity J. Cell Biol. 174 2006 323 327 (Pubitemid 44156762)
10. B. Gorsi, and S.E. Stringer Tinkering with heparan sulfate sulfation to steer development Trends Cell Biol. 17 2007 173 177 (Pubitemid 46507809)
11. I. Capila, and R.J. Linhardt Heparin-protein interactions Angew. Chem. Int. Ed. 41 2002 391 412
12. J. de Jong, R. Wevers, C. Laarakkers, and B. Poorthuis Dimethylmethylene blue-based spectrophotometry of glycosaminoglycans in untreated urine: a rapid screening procedure for mucopolysaccharidoses Clin. Chem. 35 1989 1472 1477 (Pubitemid 19187848)
13. C. DeBlois, M.-F. Côté, and C.J. Doillon Heparin-fibroblast growth factor fibrin complex: in vitro and in vivo applications to collagen-based materials Biomaterials 15 1994 665 672
14. A. Drogoz, L. David, C. Rochas, A. Domard, and T. Delair Polyelectrolyte complexes from polysaccharides: formation and stoichiometry monitoring Langmuir 23 2007 10950 10958 (Pubitemid 350069311)
15. P.-R. Chen, M.-H. Chen, F.-H. Lin, and W.-Y. Su Release characteristics and bioactivity of gelatin-tricalcium phosphate membranes covalently immobilized with nerve growth factors Biomaterials 26 2005 6579 6587 (Pubitemid 41024931)
16. M.K. Lee, and A.D. Lander Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: development of a sensitive electrophoretic approach Proc. Natl Acad. Sci. USA 88 1991 2768 2772 (Pubitemid 21916500)
17. S.E. Sakiyama-Elbert, and J.A. Hubbell Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix J. Control. Release 69 2000 149 158
18. D. Drubin, S. Feinstein, E. Shooter, and M. Kirschner Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors J. Cell Biol. 101 1985 1799 1807 (Pubitemid 16192153)
19. E.A. Silva, and D.J. Mooney Effects of VEGF temporal and spatial presentation on angiogenesis Biomaterials 31 2010 1235 1241
20. S.M. Jay, B.R. Shepherd, J.W. Andrejecsk, T.R. Kyriakides, J.S. Pober, and W.M. Saltzman Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization Biomaterials 31 2010 3054 3062
21. M.D. Wood, G.H. Borschel, and S.E. Sakiyama-Elbert Controlled release of glial-derived neurotrophic factor from fibrin matrices containing an affinity-based delivery system J. Biomed. Mater. Res. A 89A 2009 909 918
22. C.E. Kang, C.H. Tator, and M.S. Shoichet Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system J. Control. Release 144 2010 25 31
23. X.Q. Wang, E. Wenk, X.H. Zhang, L. Meinel, G. Vunjak-Novakovic, and D.L. Kaplan Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering J. Control. Release 134 2009 81 90
24. L.D. Solorio, A.S. Fu, R. Hernandez-Irizarry, and E. Alsberg Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-beta 1 from incorporated polymer microspheres J. Biomed. Mater. Res. A 92A 2010 1139 1144
25. E. Wenk, A.R. Murphy, D.L. Kaplan, L. Meinel, H.P. Merkle, and L. Uebersax The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration Biomaterials 31 2010 1403 1413
26. G. Tae, M. Scatena, P.S. Stayton, and A.S. Hoffman PEG-cross-linked heparin is an affinity hydrogel for sustained release of vascular endothelial growth factor J. Biomater. Sci. Polym. Ed. 17 2006 187 197 (Pubitemid 44069724)
27. A. Nilasaroya, L.A. Poole-Warren, J.M. Whitelock, and P. Jo Martens Structural and functional characterisation of poly(vinyl alcohol) and heparin hydrogels Biomaterials 29 2008 4658 4664
28. B.L. Seal, and A. Panitch Physical polymer matrices based on affinity interactions between peptides and polysaccharides Biomacromolecules 4 2003 1572 1582 (Pubitemid 37455568)
29. K. Rajangam, H.A. Behanna, M.J. Hui, X. Han, J.F. Hulvat, J.W. Lomasney, and S.I. Stupp Heparin binding nanostructures to promote growth of blood vessels Nano Lett. 6 2006 2086 2090 (Pubitemid 44555259)
30. P.J. Johnson, S.R. Parker, and S.E. Sakiyama-Elbert Controlled release of neurotrophin-3 from fibrin-based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury Biotechnol. Bioeng. 104 2009 1207 1214