메뉴 건너뛰기




Volumn 13, Issue 13, 2012, Pages 1911-1922

Iloperidone, asenapine and lurasidone: A primer on their current status

Author keywords

Antipsychotic drugs; Bipolar disorder; Clinical trials; Depression; Receptor pharmacology; Safety and tolerability; Schizophrenia

Indexed keywords

ASENAPINE; CIPROFLOXACIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DILTIAZEM; DRUG METABOLITE; DULOXETINE; FLUOXETINE; FLUVOXAMINE; HALOPERIDOL; ILOPERIDONE; KETOCONAZOLE; LITHIUM; LURASIDONE; NEFAZODONE; NEUROTRANSMITTER RECEPTOR; OLANZAPINE; PAROXETINE; PLACEBO; QUETIAPINE; QUINIDINE; RIFAMPICIN; RISPERIDONE; VALPROIC ACID; VERAPAMIL; ZIPRASIDONE;

EID: 84865318995     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2012.712114     Document Type: Review
Times cited : (34)

References (86)
  • 2
    • 38349057998 scopus 로고    scopus 로고
    • The burden of schizophrenia on caregivers: A review
    • Awad AG, Voruganti LN. The burden of schizophrenia on caregivers: a review. Pharmacoeconomics 2008;26:149-62
    • (2008) Pharmacoeconomics , vol.26 , pp. 149-162
    • Awad, A.G.1    Voruganti, L.N.2
  • 3
    • 0000658675 scopus 로고    scopus 로고
    • Cognitive impairment in schizophrenia
    • O'Carroll R. Cognitive impairment in schizophrenia. Adv Psychiatr Treat 2000;6:161-8
    • (2000) Adv Psychiatr Treat , vol.6 , pp. 161-168
    • O'Carroll, R.1
  • 7
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
    • Kane J, Honigfeld G, Singer J, et al. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988;45:789-96
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3
  • 8
    • 0024468417 scopus 로고
    • Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia
    • Meltzer HY. Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology (Berl) 1989;99(Suppl):S18-27 (Pubitemid 19244134)
    • (1989) Psychopharmacology , vol.99 , Issue.SUPPL.
    • Meltzer, H.Y.1
  • 10
    • 0028785179 scopus 로고
    • New insights into the biology of schizophrenia through the mechanism of action of clozapine
    • Brunello N, Masotto C, Steardo L, et al. New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacology 1995;13:177-213
    • (1995) Neuropsychopharmacology , vol.13 , pp. 177-213
    • Brunello, N.1    Masotto, C.2    Steardo, L.3
  • 11
    • 80054115183 scopus 로고    scopus 로고
    • Clozapine safety, 35 years later
    • Raja M. Clozapine safety, 35 years later. Curr Drug Saf 2011;6:164-84
    • (2011) Curr Drug Saf , vol.6 , pp. 164-184
    • Raja, M.1
  • 12
    • 84862687967 scopus 로고    scopus 로고
    • Cardiovascular side-effects of antipsychotic drugs: The role of the autonomic nervous system
    • Leung JY, Barr AM, Procyshyn RM, et al. Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system. Pharmacol Ther 2012;135:113-22
    • (2012) Pharmacol Ther , vol.135 , pp. 113-122
    • Leung, J.Y.1    Barr, A.M.2    Procyshyn, R.M.3
  • 13
    • 0036180418 scopus 로고    scopus 로고
    • Effects of newer antipsychotics on extrapyramidal function
    • Tarsy D, Baldessarini RJ, Tarazi FI. Effects of newer antipsychotics on extrapyramidal function. CNS Drugs 2002;16:23-45
    • (2002) CNS Drugs , vol.16 , pp. 23-245
    • Tarsy, D.1    Baldessarini, R.J.2    Tarazi, F.I.3
  • 14
    • 84861585734 scopus 로고    scopus 로고
    • Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: A systematic review and meta-analysis
    • Leucht S, Tardy M, Komossa K, et al. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet 2012;379:2063-71
    • (2012) Lancet , vol.379 , pp. 2063-2071
    • Leucht, S.1    Tardy, M.2    Komossa, K.3
  • 15
    • 45849139351 scopus 로고    scopus 로고
    • Antipsychotic induced weight gain in schizophrenia: Mechanisms and management
    • DOI 10.1080/00048670801961123, PII 793109482
    • Rege S. Antipsychotic induced weight gain in schizophrenia: mechanisms and management. Aust NZ J Psychiatry 2008;42:369-81 (Pubitemid 351877210)
    • (2008) Australian and New Zealand Journal of Psychiatry , vol.42 , Issue.5 , pp. 369-381
    • Rege, S.1
  • 16
    • 37249034101 scopus 로고    scopus 로고
    • Atypical antipsychotic-induced metabolic side effects: Insights from receptor-binding profiles
    • DOI 10.1038/sj.mp.4002066, PII 4002066
    • Nasrallah HA. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry 2008;13:27-35 (Pubitemid 350275185)
    • (2008) Molecular Psychiatry , vol.13 , Issue.1 , pp. 27-35
    • Nasrallah, H.A.1
  • 17
    • 57449083235 scopus 로고    scopus 로고
    • The metabolic syndrome and schizophrenia
    • Meyer JM, Stahl SM. The metabolic syndrome and schizophrenia. Acta Psychiatr Scand 2009;119:4-14
    • (2009) Acta Psychiatr Scand , vol.119 , pp. 4-14
    • Meyer, J.M.1    Stahl, S.M.2
  • 18
    • 58849138816 scopus 로고    scopus 로고
    • Which comes first: Atypical antipsychotic treatment or cardiometabolic risk?
    • Stahl SM, Mignon L, Meyer JM. Which comes first: atypical antipsychotic treatment or cardiometabolic risk? Acta Psychiatr Scand 2009;119:171-9
    • (2009) Acta Psychiatr Scand , vol.119 , pp. 171-179
    • Stahl, S.M.1    Mignon, L.2    Meyer, J.M.3
  • 20
    • 33749321169 scopus 로고    scopus 로고
    • Randomized controlled trial of the effect on quality of life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1)
    • DOI 10.1001/archpsyc.63.10.1079
    • Jones PB, Barnes TR, Davies L, et al. Randomized controlled trial of the effect on quality of life of second-vs first-generation antipsychotic drugs in schizophrenia: cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Arch Gen Psychiatry 2006;63:1079-87 (Pubitemid 44498387)
    • (2006) Archives of General Psychiatry , vol.63 , Issue.10 , pp. 1079-1087
    • Jones, P.B.1    Barnes, T.R.E.2    Davies, L.3    Dunn, G.4    Lloyd, H.5    Hayhurst, K.P.6    Murray, R.M.7    Markwick, A.8    Lewis, S.W.9
  • 22
    • 0034711425 scopus 로고    scopus 로고
    • Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds
    • Richelson E, Souder T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci 2000;68:29-39
    • (2000) Life Sci , vol.68 , pp. 29-39
    • Richelson, E.1    Souder, T.2
  • 23
    • 0035673012 scopus 로고    scopus 로고
    • Extended radioligand binding profile of iloperidone: A broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders
    • DOI 10.1016/S0893-133X(01)00285-8, PII S0893133X01002858
    • Kalkman HO, Subramanian N, Hoyer D. Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology 2001;25:904-14 (Pubitemid 34031895)
    • (2001) Neuropsychopharmacology , vol.25 , Issue.6 , pp. 904-914
    • Kalkman, H.O.1    Subramanian, N.2    Hoyer, D.3
  • 24
    • 33747053349 scopus 로고    scopus 로고
    • Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
    • DOI 10.1016/j.neuropharm.2006.04.004, PII S0028390806000955
    • Barr AM, Powell SB, Markou A, et al. Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology 2006;51:457-65 (Pubitemid 44215953)
    • (2006) Neuropharmacology , vol.51 , Issue.3 , pp. 457-465
    • Barr, A.M.1    Powell, S.B.2    Markou, A.3    Geyer, M.A.4
  • 25
    • 67649216860 scopus 로고    scopus 로고
    • Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia
    • Volpi S, Potkin SG, Malhotra AK, et al. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. J Clin Psychiatry 2009;70(6):801-9
    • (2009) J Clin Psychiatry , vol.70 , Issue.6 , pp. 801-809
    • Volpi, S.1    Potkin, S.G.2    Malhotra, A.K.3
  • 26
    • 58649100010 scopus 로고    scopus 로고
    • Asenapine: A novel psychopharmacologic agent with a unique human receptor signature
    • Shahid M, Walker GB, Zorn SH, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol 2009;23:65-73
    • (2009) J Psychopharmacol , vol.23 , pp. 65-73
    • Shahid, M.1    Walker, G.B.2    Zorn, S.H.3
  • 27
    • 58949100862 scopus 로고    scopus 로고
    • Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, alpha2-adrenergic and D2 receptors in the rat brain
    • Ghanbari R, El Mansari M, Shahid M, et al. Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, alpha2-adrenergic and D2 receptors in the rat brain. Eur Neuropsychopharmacol 2009;19:177-87
    • (2009) Eur Neuropsychopharmacol , vol.19 , pp. 177-187
    • Ghanbari, R.1    El Mansari, M.2    Shahid, M.3
  • 29
    • 70349652500 scopus 로고    scopus 로고
    • Asenapine effects in animal models of psychosis and cognitive function
    • Marston HM, Young JW, Martin FD. Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacology (Berl) 2009;206:699-714
    • (2009) Psychopharmacology (Berl) , vol.206 , pp. 699-714
    • Marston, H.M.1    Young, J.W.2    Martin, F.D.3
  • 30
    • 79953671335 scopus 로고    scopus 로고
    • Asenapine improves phencyclidine-induced object recognition deficits in the rat: Evidence for engagement of a dopamine D1 receptor mechanism
    • Snigdha S, Idris N, Grayson B, et al. Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism. Psychopharmacology (Berl) 2011;214:843-53
    • (2011) Psychopharmacology (Berl) , vol.214 , pp. 843-853
    • Snigdha, S.1    Idris, N.2    Grayson, B.3
  • 31
    • 84856089041 scopus 로고    scopus 로고
    • Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration
    • Elsworth JD, Groman SM, Jentsch JD, et al. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology 2012;62:1442-52
    • (2012) Neuropharmacology , vol.62 , pp. 1442-1452
    • Elsworth, J.D.1    Groman, S.M.2    Jentsch, J.D.3
  • 32
    • 67349146428 scopus 로고    scopus 로고
    • Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms
    • Frånberg O, Marcus MM, Ivanov V, et al. Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms. Psychopharmacology (Berl) 2009;204:251-64
    • (2009) Psychopharmacology (Berl) , vol.204 , pp. 251-264
    • Frånberg, O.1    Marcus, M.M.2    Ivanov, V.3
  • 33
    • 53949102049 scopus 로고    scopus 로고
    • Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus
    • Huang M, Li Z, Dai J, et al. Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus. Neuropsychopharmacology 2008;33:2934-45
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2934-2945
    • Huang, M.1    Li, Z.2    Dai, J.3
  • 34
    • 43049098484 scopus 로고    scopus 로고
    • Differential regional and dose-related effects of asenapine on dopamine receptor subtypes
    • Tarazi FI, Moran-Gates T, Wong EH, et al. Differential regional and dose-related effects of asenapine on dopamine receptor subtypes. Psychopharmacology (Berl) 2008;198:103-11
    • (2008) Psychopharmacology (Berl) , vol.198 , pp. 103-111
    • Tarazi, F.I.1    Moran-Gates, T.2    Wong, E.H.3
  • 35
    • 66049107219 scopus 로고    scopus 로고
    • Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain
    • Tarazi FI, Choi YK, Gardner M, et al. Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain. Synapse 2009;63:413-20
    • (2009) Synapse , vol.63 , pp. 413-420
    • Tarazi, F.I.1    Choi, Y.K.2    Gardner, M.3
  • 36
    • 77953076000 scopus 로고    scopus 로고
    • Asenapine induces differential regional effects on serotonin receptor subtypes
    • Tarazi FI, Moran-Gates T, Wong EH, et al. Asenapine induces differential regional effects on serotonin receptor subtypes. J Psychopharmacol 2010;24:341-8
    • (2010) J Psychopharmacol , vol.24 , pp. 341-348
    • Tarazi, F.I.1    Moran-Gates, T.2    Wong, E.H.3
  • 37
    • 77953539184 scopus 로고    scopus 로고
    • Repeated effects of asenapine on adrenergic and cholinergic muscarinic receptors
    • Choi YK, Wong EH, Henry B, et al. Repeated effects of asenapine on adrenergic and cholinergic muscarinic receptors. Int J Neuropsychopharmacol 2010;13:405-10
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 405-410
    • Choi, Y.K.1    Wong, E.H.2    Henry, B.3
  • 38
    • 77953753014 scopus 로고    scopus 로고
    • Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity
    • Ishibashi T, Horisawa T, Tokuda K, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther 2010;334:171-81
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 171-181
    • Ishibashi, T.1    Horisawa, T.2    Tokuda, K.3
  • 39
    • 38949090435 scopus 로고    scopus 로고
    • Iloperidone: A new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market?
    • DOI 10.1517/13543784.17.1.61
    • Albers LJ, Musenga A, Raggi MA. Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? Expert Opin Investig Drugs 2008;17:61-75 (Pubitemid 351578211)
    • (2008) Expert Opinion on Investigational Drugs , vol.17 , Issue.1 , pp. 61-75
    • Albers, L.J.1    Musenga, A.2    Raggi, M.A.3
  • 40
    • 0033646827 scopus 로고    scopus 로고
    • An assessment of iloperidone for the treatment of schizophrenia
    • Jain KK. An assessment of iloperidone for the treatment of schizophrenia. Expert Opin Investig Drugs 2000;9:2935-43
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2935-2943
    • Jain, K.K.1
  • 41
    • 0036199878 scopus 로고    scopus 로고
    • Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone
    • DOI 10.1016/S0278-5846(01)00307-4, PII S0278584601003074
    • Subramanian N, Kalkman HO. Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:553-60 (Pubitemid 34252950)
    • (2002) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.26 , Issue.3 , pp. 553-560
    • Subramanian, N.1    Kalkman, H.O.2
  • 43
    • 84872674315 scopus 로고    scopus 로고
    • Iloperidone Is Well Tolerated by Subjects with Renal or Hepatic Impairment in Single-dose Clinical Pharmacokinetic Studies
    • 27 May 2007; San Diego, CA
    • Sedek G, Wolfgang CD. Iloperidone is well tolerated by subjects with renal or hepatic impairment in single-dose clinical pharmacokinetic studies. Presented at American Psychiatric Association Annual Meeting; 27 May 2007; San Diego, CA
    • Presented at American Psychiatric Association Annual Meeting
    • Sedek, G.1    Wolfgang, C.D.2
  • 45
    • 77949379494 scopus 로고    scopus 로고
    • Asenapine maleate: A new drug for the treatment of schizophrenia and bipolar mania
    • Tarazi FI, Shahid M. Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania. Drugs Today 2009;45:865-76
    • (2009) Drugs Today , vol.45 , pp. 865-876
    • Tarazi, F.I.1    Shahid, M.2
  • 47
    • 84865334315 scopus 로고    scopus 로고
    • Asenapine Pharmacokinetics: Influence of Hepatic and Renal Impairment [abstract NR4-081]
    • 3-8 May, Washington DC
    • Peeters PAM, Bockbrader H, Spaans E, et al. Asenapine pharmacokinetics: influence of hepatic and renal impairment [abstract NR4-081]. 161st Amer Psychiatric Assoc; 3-8 May, Washington DC; 2008
    • (2008) 161st Amer Psychiatric Assoc
    • Peeters, P.A.M.1    Bockbrader, H.2    Spaans, E.3
  • 53
    • 67749095284 scopus 로고    scopus 로고
    • Iloperidone for schizophrenia: A review of the efficacy and safety profile for this newly commercialized second-generation antipsychotic
    • Citrome L. Iloperidone for schizophrenia: a review of the efficacy and safety profile for this newly commercialized second-generation antipsychotic. Int J Clin Pract 2009;63:1237-48
    • (2009) Int J Clin Pract , vol.63 , pp. 1237-1248
    • Citrome, L.1
  • 56
    • 40849089245 scopus 로고    scopus 로고
    • Efficacy of iloperidone in the treatment of schizophrenia: Initial phase 3 studies
    • Potkin SG, Litman RE, Torres R, et al. Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies. J Clin Psychopharmacol 2008;28(2 Suppl 1):S4-11
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.2 SUPPL. 1
    • Potkin, S.G.1    Litman, R.E.2    Torres, R.3
  • 57
    • 40849111788 scopus 로고    scopus 로고
    • Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia
    • DOI 10.1097/JCP.0b013e318169d4ce, PII 0000471420080400100004
    • Cutler AJ, Kalali AH, Weiden PJ, et al. Four-week, double-blind, placebo-and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. J Clin Psychopharmacol 2008;28(2 Suppl 1):S20-8 (Pubitemid 351397673)
    • (2008) Journal of Clinical Psychopharmacology , vol.28 , Issue.7 SUPPL. 1
    • Cutler, A.J.1    Kalali, A.H.2    Weiden, P.J.3    Hamilton, J.4    Wolfgang, C.D.5
  • 58
    • 84856324879 scopus 로고    scopus 로고
    • Efficacy of iloperidone in the short-term treatment of schizophrenia: A post hoc analysis of pooled patient data from four phase III, placebo-and active-controlled trials
    • Citrome L, Meng X, Hochfeld M, et al. Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo-and active-controlled trials. Hum Psychopharmacol 2012;27:24-32
    • (2012) Hum Psychopharmacol , vol.27 , pp. 24-32
    • Citrome, L.1    Meng, X.2    Hochfeld, M.3
  • 59
    • 40849114977 scopus 로고    scopus 로고
    • Long-term efficacy and safety of iloperidone: Results from 3 clinical trials for the treatment of schizophrenia
    • DOI 10.1097/JCP.0b013e318169cca7, PII 0000471420080400100005
    • Kane JM, Lauriello J, Laska E, et al. Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia. J Clin Psychopharmacol 2008;28(2 Suppl 1):S29-35 (Pubitemid 351397674)
    • (2008) Journal of Clinical Psychopharmacology , vol.28 , Issue.7 SUPPL. 1
    • Kane, J.M.1    Lauriello, J.2    Laska, E.3    Di Marino, M.4    Wolfgang, C.D.5
  • 60
    • 35948982974 scopus 로고    scopus 로고
    • Efficacy and tolerability of asenapine in acute schizophrenia: A placebo- and risperidone-controlled trial
    • Potkin SG, Cohen M, Panagides J. Efficacy and tolerability of asenapine in acute schizophrenia: a placebo-and risperidone-controlled trial. J Clin Psychiatry 2007;68:1492-500 (Pubitemid 350073395)
    • (2007) Journal of Clinical Psychiatry , vol.68 , Issue.10 , pp. 1492-1500
    • Potkin, S.G.1    Cohen, M.2    Panagides, J.3
  • 61
    • 84872647689 scopus 로고    scopus 로고
    • Efficacy and Safety of Asenapine in Patients with Acute Schizophrenia [abstract 290]
    • 7-10 October; Charleston, SC
    • Kane JM, Zhao J, Cohen M, et al. Efficacy and safety of asenapine in patients with acute schizophrenia [abstract 290]. 23rd Amer Psychiatric Nurses Assoc; 7-10 October; Charleston, SC; 2009
    • (2009) 23rd Amer Psychiatric Nurses Assoc
    • Kane, J.M.1    Zhao, J.2    Cohen, M.3
  • 62
    • 77949421187 scopus 로고    scopus 로고
    • Double-blind Placebo-controlled Trial of Asenapine in Prevention of Relapse after Long-term Treatment of Schizophrenia [abstract P.3.c.057]
    • 12-16 September; Istanbul, Turkey
    • Mackle M, Snow-Adami L, Zhao J, et al. Double-blind placebo-controlled trial of asenapine in prevention of relapse after long-term treatment of schizophrenia [abstract P.3.c.057]. 22nd Cong Eur Coll Neuropsychopharmacol; 12-16 September; Istanbul, Turkey; 2009
    • (2009) 22nd Cong Eur Coll Neuropsychopharmacol
    • MacKle, M.1    Snow-Adami, L.2    Zhao, J.3
  • 63
    • 84855339931 scopus 로고    scopus 로고
    • Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia
    • Buchanan RW, Panagides J, Zhao J, et al. Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia. J Clin Psychopharmacol 2012;32:36-45
    • (2012) J Clin Psychopharmacol , vol.32 , pp. 36-45
    • Buchanan, R.W.1    Panagides, J.2    Zhao, J.3
  • 64
    • 84872650573 scopus 로고    scopus 로고
    • Treatment of Mania in Bipolar i Disorder: Placebo-and Olanzapine-controlled Trials of Asenapine [abstract P2.e.012]
    • 13-17 October; Vienna, Austria
    • McIntyre RS, Alphs L, Cohen M, et al. Treatment of mania in bipolar I disorder: placebo-and olanzapine-controlled trials of asenapine [abstract P2.e.012]. 20th Congr Eur Coll Neuropsychopharmacol; 13-17 October; Vienna, Austria; 2007
    • (2007) 20th Congr Eur Coll Neuropsychopharmacol
    • McIntyre, R.S.1    Alphs, L.2    Cohen, M.3
  • 65
    • 65249127351 scopus 로고    scopus 로고
    • Asenapine in acute mania: A randomized, double-blind, placebo-and olanzapine-controlled trial (ARES 7501004)
    • McIntyre RS, Panagides J, Alphs L, et al. Asenapine in acute mania: a randomized, double-blind, placebo-and olanzapine-controlled trial (ARES 7501004). Biol Psychiatry 2007;61(S 8):S222-3
    • (2007) Biol Psychiatry , vol.61 , Issue.S8
    • McIntyre, R.S.1    Panagides, J.2    Alphs, L.3
  • 66
    • 70350540771 scopus 로고    scopus 로고
    • A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states
    • McIntyre RS, Cohen M, Zhao J, et al. A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states. Bipolar Disord 2009;11:673-86
    • (2009) Bipolar Disord , vol.11 , pp. 673-686
    • McIntyre, R.S.1    Cohen, M.2    Zhao, J.3
  • 67
    • 84855345812 scopus 로고    scopus 로고
    • Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: Results of a 12-week core study and 40-week extension
    • Szegedi A, Calabrese JR, Stet L, et al. Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension. J Clin Psychopharmacol 2012;32:46-55
    • (2012) J Clin Psychopharmacol , vol.32 , pp. 46-55
    • Szegedi, A.1    Calabrese, J.R.2    Stet, L.3
  • 68
    • 78751501996 scopus 로고    scopus 로고
    • Efficacy of lurasidone (SM-13496) in the treatment of schizophrenia: Results of two phase 2, placebo-conrolled studies
    • Ogasa M, Boylan M, Phillips D, et al. Efficacy of lurasidone (SM-13496) in the treatment of schizophrenia: results of two phase 2, placebo-conrolled studies. Eur Neuropsychopharmacol 2005;15:S522-3
    • (2005) Eur Neuropsychopharmacol , vol.15
    • Ogasa, M.1    Boylan, M.2    Phillips, D.3
  • 69
    • 78751484133 scopus 로고    scopus 로고
    • Efficacy of lurasidone in schizophrenia: Results of a phase 2, placebo-controlled study
    • Phillips D, Ogasa M, Severs J, et al. Efficacy of lurasidone in schizophrenia: results of a phase 2, placebo-controlled study. Schizophr Bull 2007;33:572-3
    • (2007) Schizophr Bull , vol.33 , pp. 572-573
    • Phillips, D.1    Ogasa, M.2    Severs, J.3
  • 70
    • 78751554762 scopus 로고    scopus 로고
    • Efficacy of lurasidone in schizophrenia: Summary of results from the clinical development program
    • Loebel A, Cucchiaro J, Ogasa M. Efficacy of lurasidone in schizophrenia: summary of results from the clinical development program. Int J Neuropsychopharmacol 2010;13(Suppl 1):217
    • (2010) Int J Neuropsychopharmacol , vol.13 , Issue.SUPPL. 1 , pp. 217
    • Loebel, A.1    Cucchiaro, J.2    Ogasa, M.3
  • 71
    • 80052477010 scopus 로고    scopus 로고
    • Lurasidone in the treatment of schizophrenia: A randomized, double-blind, placebo-and olanzapine-controlled Study
    • Meltzer HY, Cucchiaro J, Silva R, et al. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo-and olanzapine-controlled Study. Am J Psychiatry 2011;168:957-67
    • (2011) Am J Psychiatry , vol.168 , pp. 957-967
    • Meltzer, H.Y.1    Cucchiaro, J.2    Silva, R.3
  • 72
    • 84872659928 scopus 로고    scopus 로고
    • Lurasidone in the Treatment of Acute Schizophrenia: Results of the Double-blind Placebo-controlled 6-week Pearl 3 Trial [abstract No NR6-38]
    • 14-18 May 2011; Honolulu, HA
    • Loebel A, Cucchiaro J, Sarma K, et al. Lurasidone in the treatment of acute schizophrenia: Results of the double-blind, placebo-controlled, 6-week, Pearl 3 trial [abstract no NR6-38]. 164th Annual Meeting of the American Psychiatric Association; 14-18 May 2011; Honolulu, HA
    • 164th Annual Meeting of the American Psychiatric Association
    • Loebel, A.1    Cucchiaro, J.2    Sarma, K.3
  • 73
    • 40849102838 scopus 로고    scopus 로고
    • Safety profile of iloperidone: A pooled analysis of 6-week acute-phase pivotal trials
    • DOI 10.1097/JCP.0b013e3181694f5a, PII 0000471420080400100003
    • Weiden PJ, Cutler AJ, Polymeropoulos MH, Wolfgang CD. Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. J Clin Psychopharmacol 2008;28(2 Suppl 1):S12-19 (Pubitemid 351397672)
    • (2008) Journal of Clinical Psychopharmacology , vol.28 , Issue.7 SUPPL. 1
    • Weiden, P.J.1    Cutler, A.J.2    Polymeropoulos, M.H.3    Wolfgang, C.D.4
  • 74
    • 67649222011 scopus 로고    scopus 로고
    • Lurasidone in the treatment of acute schizophrenia: A double-blind, placebo-controlled trial
    • Nakamura M, Ogasa M, Guarino J, et al. Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial. J Clin Psychiatry 2009;70:829-36
    • (2009) J Clin Psychiatry , vol.70 , pp. 829-836
    • Nakamura, M.1    Ogasa, M.2    Guarino, J.3
  • 75
    • 70350424361 scopus 로고    scopus 로고
    • Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine, quetiapine, or placebo administration on QTc prolongation
    • Chapel S, Hutmatcher M, Haig G, et al. Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine, quetiapine, or placebo administration on QTc prolongation. J Clin Psychopharmacol 2009;49:1297-308
    • (2009) J Clin Psychopharmacol , vol.49 , pp. 1297-1308
    • Chapel, S.1    Hutmatcher, M.2    Haig, G.3
  • 76
    • 78650662417 scopus 로고    scopus 로고
    • Lurasidone for schizophrenia: A review of the efficacy and safety profile for this newly approved second-generation antipsychotic
    • Citrome L. Lurasidone for schizophrenia: a review of the efficacy and safety profile for this newly approved second-generation antipsychotic. Int J Clin Pract 2011;65:189-210
    • (2011) Int J Clin Pract , vol.65 , pp. 189-210
    • Citrome, L.1
  • 77
    • 84884613805 scopus 로고    scopus 로고
    • Effectiveness of Lurasidone Vs. Quetiapine XR for Relapse Prevention in Schizophrenia: A 12-month Double-blind Study [abstract No NR6-36]
    • 5-9 May 2012; Philadelphia, PA
    • Loebel A, Cucchiaro J, Xu J, et al. Effectiveness of lurasidone vs. quetiapine XR for relapse prevention in schizophrenia: A 12-month, double-blind study [abstract no NR6-36]. 165th Annual Meeting of the American Psychiatric Association; 5-9 May 2012; Philadelphia, PA
    • 165th Annual Meeting of the American Psychiatric Association
    • Loebel, A.1    Cucchiaro, J.2    Xu, J.3
  • 78
    • 33645230435 scopus 로고    scopus 로고
    • Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: Focus on novel therapeutic strategies
    • Millan MJ. Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 2005;60:441-60
    • (2005) Therapie , vol.60 , pp. 441-460
    • Millan, M.J.1
  • 79
    • 79954597841 scopus 로고    scopus 로고
    • Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy
    • Mnie-Filali O, Faure C, Lambás-Señas L, et al. Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy. Neuropsychopharmacology 2011;36:1275-88
    • (2011) Neuropsychopharmacology , vol.36 , pp. 1275-1288
    • Mnie-Filali, O.1    Faure, C.2    Lambás-Señas, L.3
  • 80
    • 84872652868 scopus 로고    scopus 로고
    • Lurasidone Monotherapy for the Treatment of Bipolar i Depression: Results of A 6-week Double-blind Placebo-controlled Study [abstract No NR4-58]
    • 5-9 May 2012; Philadelphia, PA
    • Loebel A, Cucchiaro J, Silva R, et al. Lurasidone monotherapy for the treatment of bipolar I depression: Results of a 6-week, double-blind, placebo-controlled study [abstract no NR4-58]. 165th Annual Meeting of the American Psychiatric Association; 5-9 May 2012; Philadelphia, PA
    • 165th Annual Meeting of the American Psychiatric Association
    • Loebel, A.1    Cucchiaro, J.2    Silva, R.3
  • 81
    • 80052931210 scopus 로고    scopus 로고
    • Agomelatine for the treatment of major depressive disorder
    • Carney RM, Shelton RC. Agomelatine for the treatment of major depressive disorder. Expert Opin Pharmacother 2011;12:2411-19
    • (2011) Expert Opin Pharmacother , vol.12 , pp. 2411-2419
    • Carney, R.M.1    Shelton, R.C.2
  • 83
    • 65049083026 scopus 로고    scopus 로고
    • 5-HT1A receptor function in major depressive disorder
    • Savitz J, Lucki I, Drevets WC. 5-HT1A receptor function in major depressive disorder. Prog Neurobiol 2009;88:17-31
    • (2009) Prog Neurobiol , vol.88 , pp. 17-31
    • Savitz, J.1    Lucki, I.2    Drevets, W.C.3
  • 84
    • 74949137041 scopus 로고    scopus 로고
    • Therapeutic options for treatment-resistant depression
    • Shelton RC, Osuntokun O, Heinloth AN, et al. Therapeutic options for treatment-resistant depression. CNS Drugs 2010;24:131-61
    • (2010) CNS Drugs , vol.24 , pp. 131-161
    • Shelton, R.C.1    Osuntokun, O.2    Heinloth, A.N.3
  • 86
    • 62449321971 scopus 로고    scopus 로고
    • Selective histamine H1 antagonism: Novel hypnotic and pharmacologic actions challenge classical notions of antihistamines
    • 1969-1983
    • Stahl SM. Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr 2008;13:1027-38:1969-1983
    • (2008) CNS Spectr , vol.13 , pp. 1027-1038
    • Stahl, S.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.