Asenapine effects in animal models of psychosis and cognitive function

Psychopharmacology

Volumn 206, Issue 4, 2009, Pages 699-714

  Marston, Hugh M ^a   Young, Jared W ^b   Martin, Frederic D C ^a   Serpa, Kevin A ^c   Moore, Christopher L ^c   Wong, Erik H F ^c   Gold, Lisa ^c   Meltzer, Leonard T ^c   Azar, Marc R ^d   Geyer, Mark A ^b   Shahid, Mohammed ^a  

^a Schering Plough Research Institute   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PFIZER INC   (United States)

^d Behavioral Pharma Inc   (United States)

Author keywords

Amphetamine; Antipsychotic; Apomorphine; Asenapine; Attention; Delayed non match to place; Five choice serial reaction; Locomotor activity; Prepulse inhibition; Short term spatial memory

Indexed keywords

AMPHETAMINE; ASENAPINE; OLANZAPINE; RISPERIDONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; HABITUATION; LOCOMOTION; MALE; MOTOR PERFORMANCE; NONHUMAN; PREDICTION; PREPULSE INHIBITION; PRIORITY JOURNAL; PSYCHOSIS; RAT; SHORT TERM MEMORY; SPATIAL MEMORY; STARTLE REFLEX; TASK PERFORMANCE;

AMPHETAMINE; ANIMALS; ANTIPSYCHOTIC AGENTS; APOMORPHINE; ATTENTION; BENZODIAZEPINES; COGNITION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MALE; PSYCHOTIC DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; RISPERIDONE;

EID: 70349652500     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1570-z     Document Type: Article

References (54)

1. Z Abdul-Monim GP Reynolds JC Neill 2003 The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat J Psychopharmacol 17 57 65 12680740 10.1177/0269881103017001700 1:CAS:528:DC%2BD3sXjtVSjtbk%3D (Pubitemid 36373141)
2. Z Abdul-Monim GP Reynolds JC Neill 2006 The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm Behav Brain Res 169 263 273 16500717 10.1016/j.bbr.2006.01.019 1:CAS:528:DC%2BD28XivVCls7w%3D
3. J Addington D Addington L Gasbarre 2001 Neurocognitive and social functioning in schizophrenia and other diagnoses Schizophr Res 48 367 368 11295389 10.1016/S0920-9964(00)00103-1 1:STN:280:DC%2BD3MvgvFymtg%3D%3D (Pubitemid 32274333)
4. N Amitai A Markou 2009 Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration Psychopharmacology (Berl) 202 275 286 10.1007/s00213-008-1246-0 1:CAS:528:DC%2BD1MXht1ehsLw%3D
5. N Amitai S Semenova A Markou 2007 Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats Psychopharmacology (Berl) 193 521 537 10.1007/s00213-007- 0808-x 1:CAS:528:DC%2BD2sXotVWmtbk%3D (Pubitemid 47094377)
6. J Arnt 1995 Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine Eur J Pharmacol 283 55 62 7498321 10.1016/0014-2999(95)00292-S 1:CAS:528:DyaK2MXnvFWiu7c%3D
7. J Arnt T Skarsfeldt 1998 Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence Neuropsychopharmacology 18 63 101 9430133 10.1016/S0893-133X(97)00112-7 1:CAS:528:DyaK1cXht1GhsQ%3D%3D (Pubitemid 28026679)
8. AL Auclair MS Kleven J Besnard R Depoortere A Newman-Tancredi 2006 Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade Neuropsychopharmacology 31 1900 1909 16421514 10.1038/sj.npp.1301015 1:CAS:528:DC%2BD28XotFKlurY%3D (Pubitemid 44246336)
9. JM Birrell VJ Brown 2000 Medial frontal cortex mediates perceptual attentional set shifting in the rat J Neurosci 20 4320 4324 10818167 1:CAS:528:DC%2BD3cXjsFeksr0%3D
10. MJ Cuesta V Peralta A Zarzuela 2001 Effects of olanzapine and other antipsychotics on cognitive function in chronic schizophrenia: a longitudinal study Schizophr Res 48 17 28 11278151 10.1016/S0920-9964(00)00112-2 1:STN:280:DC%2BD3M7ovF2mtQ%3D%3D (Pubitemid 32241180)
11. M Didriksen 1995 Effects of antipsychotics on cognitive behaviour in rats using the delayed non-match to position paradigm Eur J Pharmacol 281 241 250 8521906 10.1016/0014-2999(95)00242-D 1:CAS:528:DyaK2MXnsFWnsL8%3D
12. M Didriksen T Skarsfeldt J Arnt 2007 Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics Psychopharmacology (Berl) 193 225 233 10.1007/s00213-007-0774-3 1:CAS:528:DC%2BD2sXntFGqtLw%3D (Pubitemid 47025022)
13. DJ Feldman RA Frank JH Kehne R Flannery D Brown S Soni G Byrd S Shah 1997 Mixed D2/5-HT2 antagonism differentially affects apomorphine- and amphetamine-induced stereotyped behavior Pharmacol Biochem Behav 58 565 572 9300620 10.1016/S0091-3057(97)00292-X 1:CAS:528:DyaK2sXlvVGgtLc%3D (Pubitemid 27394313)
14. Fleming K, Potkin SG, Binneman B, Keller DS, Alphs L, Panagides J (2007) Asenapine improves cognitive function in acute schizophrenia: a placebo- and risperidone-controlled trial. Paper presented at: 160th Annual Meeting of the American Psychiatric Association, May 19-24, 2007; San Diego, CA
15. O Franberg C Wiker MM Marcus A Konradsson K Jardemark B Schilstrom M Shahid EH Wong TH Svensson 2008 Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia Psychopharmacology (Berl) 196 417 429 10.1007/s00213-007-0973-y 1:CAS:528:DC%2BD1cXht1Knsbw%3D (Pubitemid 351200428)
16. MA Geyer B Ellenbroek 2003 Animal behavior models of the mechanisms underlying antipsychotic atypicality Prog Neuropsychopharmacol Biol Psychiatry 27 1071 1079 14642967 10.1016/j.pnpbp.2003.09.003 1:CAS:528:DC%2BD3sXpt1Sgt7c%3D (Pubitemid 37464953)
17. MA Geyer K Krebs-Thomson DL Braff NR Swerdlow 2001 Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review Psychopharmacology (Berl) 156 117 154 10.1007/s002130100811 1:CAS:528:DC%2BD3MXmtlCqtLY%3D (Pubitemid 32702206)
18. B Grayson NF Idris JC Neill 2007 Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat Behav Brain Res 184 31 38 17675172 10.1016/j.bbr.2007.06.012 1:CAS:528:DC%2BD2sXhtVOgtrjL (Pubitemid 47404650)
19. JJ Hagan DN Jones 2005 Predicting drug efficacy for cognitive deficits in schizophrenia Schizophr Bull 31 830 853 16177277 10.1093/schbul/sbi058 (Pubitemid 41437777)
20. PD Hatcher VJ Brown DS Tait S Bate P Overend JJ Hagan DN Jones 2005 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats Psychopharmacology (Berl) 181 253 259 10.1007/s00213-005-2261-z 1:CAS:528:DC%2BD2MXhtFCrtL3L (Pubitemid 41492195)
21. WD Hirst TO Stean DC Rogers D Sunter P Pugh SF Moss SM Bromidge G Riley DR Smith S Bartlett CA Heidbreder AR Atkins LP Lacroix LA Dawson AG Foley CM Regan N Upton 2006 SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models Eur J Pharmacol 553 109 119 17069795 10.1016/j.ejphar.2006. 09.049 1:CAS:528:DC%2BD28Xht1Ciu7nO (Pubitemid 44779592)
22. M Huang Z Li J Dai M Shahid EH Wong HY Meltzer 2008 Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus Neuropsychopharmacology 33 2934 2945 18418367 10.1038/npp.2008.20 1:CAS:528:DC%2BD1cXht1Cms7fP
23. NF Idris P Repeto JC Neill CH Large 2005 Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat Psychopharmacology (Berl) 179 336 348 10.1007/s00213-004-2058-5 1:CAS:528:DC%2BD2MXjtV2hsro%3D
24. Institute of Laboratory Animal Resources (1996) Guide for the care and use of laboratory animals-ILAR, National Research Council. National Academy Press, Washington, DC
25. JD Jentsch M Shahid EHF Wong RH Roth 2006 Asenapine improves cognitve function in monkeys repeatedly exposed to the psychotomimetic drug phencyclidine Biol Psychiatry 59 471
26. S Kapur D Mamo 2003 Half a century of antipsychotics and still a central role for dopamine D2 receptors Prog Neuropsychopharmacol Biol Psychiatry 27 1081 1090 14642968 10.1016/j.pnpbp.2003.09.004 1:CAS:528:DC%2BD3sXpt1SgtL4%3D (Pubitemid 37464954)
27. ED Levin NC Christopher 2006 Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 30 223 229 16356617 10.1016/j.pnpbp.2005. 10.018 1:CAS:528:DC%2BD28XhvVWlu7c%3D (Pubitemid 43288062)
28. JA Lieberman TS Stroup JP McEvoy MS Swartz RA Rosenheck DO Perkins RS Keefe SM Davis CE Davis BD Lebowitz J Severe JK Hsiao Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators 2005 Effectiveness of antipsychotic drugs in patients with chronic schizophrenia N Engl J Med 353 1209 1223 16172203 10.1056/NEJMoa051688 1:CAS:528:DC%2BD2MXhtVeltL%2FN (Pubitemid 41345943)
29. RS Mansbach MA Geyer DL Braff 1988 Dopaminergic stimulation disrupts sensorimotor gating in the rat Psychopharmacology (Berl) 94 507 514 10.1007/BF00212846 1:CAS:528:DyaL1cXktVCktbs%3D
30. 2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat Int J Neuropsychopharmacol 8 315 327 15857571 10.1017/S1461145705005328 1:CAS:528:DC%2BD2MXlsFams70%3D (Pubitemid 41002487)
31. R McIntyre R Hirschfeld J Calabrese A Szegedi 2008 Asenapine in bipolar disorder: an overview of the clinical trials in the Olympia program Int J Neuropsychopharmacol 11 suppl 1 183
32. DD Miller 2004 Atypical antipsychotics: sleep, sedation, and efficacy Prim Care Companion J Clin Psychiat 6 3 7 10.4088/PCC.v06n0101
33. S Nakai T Hirose T Mori A Stark H Araki T Kikuchi 2008 The effect of aripiprazole on prepulse inhibition of the startle response in normal and hyperdopaminergic states in rats Int J Neurosci 118 39 57 18041605 10.1080/00207450601041989 1:CAS:528:DC%2BD2sXhtlGhsr%2FI (Pubitemid 350175300)
34. JC Neill M Shahid EHF Wong NF Idris 2006 Comparison of the efficacy of asenapine, risperidone, and olanzapine to improve a reversal learning deficit in the rat Schizophr Res 81 s105 s106
35. JC Neill M Shahid B Grayson HM Marston S Snigdha 2008 Asenapine improves a subchronic phencyclidine-induced deficit in object recognition memory in the rat Biol Psychol 63 75S 76S
36. RE Nordquist C Risterucci JL Moreau M von Kienlin B Kunnecke M Maco C Freichel C Riemer W Spooren 2008 Effects of aripiprazole/OPC-14597 on motor activity, pharmacological models of psychosis, and brain activity in rats Neuropharmacology 54 405 416 18054053 10.1016/j.neuropharm.2007.10.010 1:CAS:528:DC%2BD1cXpt1Kgug%3D%3D
37. SG Potkin M Cohen J Panagides 2007 Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial J Clin Psychiatry 68 1492 1500 17960962 10.4088/JCP.v68n1004 1:CAS:528: DC%2BD2sXhtlCqtr%2FK
38. D Quarta CG Naylor HV Morris S Patel RF Genn IP Stolerman 2007 Different effects of ionotropic and metabotropic glutamate receptor antagonists on attention and the attentional properties of nicotine Neuropharmacology 53 421 430 17631918 10.1016/j.neuropharm.2007.05.023 1:CAS:528:DC%2BD2sXovFers7g%3D (Pubitemid 47212250)
39. G Remington 2003 Understanding antipsychotic "atypicality": a clinical and pharmacological moving target J Psychiatry Neurosci 28 275 284 12921222
40. H Rosengarten D Quartermain 2002 The effect of chronic treatment with typical and atypical antipsychotics on working memory and jaw movements in three- and eighteen-month-old rats Prog Neuropsychopharmacol Biol Psychiatry 26 1047 1054 12452525 10.1016/S0278-5846(02)00221-X 1:CAS:528:DC%2BD38XntVWqurc%3D (Pubitemid 35256096)
41. A Schotte PF Janssen W Gommeren WH Luyten P Van Gompel AS Lesage K De Loore JE Leysen 1996 Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding Psychopharmacology (Berl) 124 57 73 10.1007/BF02245606 1:CAS:528:DyaK28XjsFGktLk%3D (Pubitemid 26112775)
42. M Shahid G Walker S Zorn E Wong 2009 Asenapine: a novel psychopharmacologic agent with a unique human receptor signature J Psychopharmacol 23 65 73 18308814 10.1177/0269881107082944 1:CAS:528: DC%2BD1MXisVClu7Y%3D
43. T Sharma L Antonova 2003 Cognitive function in schizophrenia. Deficits, functional consequences, and future treatment Psychiatr Clin North Am 26 25 40 12683258 10.1016/S0193-953X(02)00084-9 (Pubitemid 36384346)
44. AD Smith DL Smith MJ Zigmond M Amalric GF Koob 2000 Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm Psychopharmacology (Berl) 148 355 360 10.1007/s002130050063 1:CAS:528:DC%2BD3cXislSktbg%3D
45. IA Sukhotina OA Dravolina Y Novitskaya EE Zvartau W Danysz AY Bespalov 2008 Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats Psychopharmacology (Berl) 196 211 220 10.1007/s00213-007- 0953-2 1:CAS:528:DC%2BD1cXpsF2ktg%3D%3D
46. NR Swerdlow GB Varty MA Geyer 1998 Discrepant findings of clozapine effects on prepulse inhibition of startle: is it the route or the rat? Neuropsychopharmacology 18 50 56 9408918 10.1016/S0893-133X(97)00110-3 1:CAS:528:DyaK2sXnvV2msbo%3D (Pubitemid 28116373)
47. DS Tait HM Marston M Shahid VJ Brown 2009 Asenapine restores cognitive flexibility in rats with medial prefrontal cortex lesions Psychopharmacology (Berl) 202 295 306 10.1007/s00213-008-1364-8 1:CAS:528:DC%2BD1cXht1GlsbnJ
48. FI Tarazi T Moran-Gates EH Wong B Henry M Shahid 2008 Differential regional and dose-related effects of asenapine on dopamine receptor subtypes Psychopharmacology (Berl) 198 103 111 10.1007/s00213-008-1098-7 1:CAS:528:DC%2BD1cXlt1CrtLY%3D
49. JP Terranova C Chabot MC Barnouin G Perrault R Depoortere G Griebel B Scatton 2005 SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit Psychopharmacology (Berl) 181 134 144 10.1007/s00213-005-2268-5 1:CAS:528:DC%2BD2MXhtFWmt7vI (Pubitemid 41440924)
50. AV Terry Jr WD Hill V Parikh JL Waller DR Evans SP Mahadik 2003 Differential effects of haloperidol, risperidone, and clozapine exposure on cholinergic markers and spatial learning performance in rats Neuropsychopharmacology 28 300 309 12589383 10.1038/sj.npp.1300039 1:CAS:528:DC%2BD3sXhtFGhtr0%3D
51. GB Varty MA Geyer 1998 Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats Behav Neurosci 112 1450 1457 9926827 10.1037/0735-7044. 112.6.1450 1:STN:280:DyaK1M7isVSitQ%3D%3D (Pubitemid 29052632)
52. GB Varty GA Higgins 1995 Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs Psychopharmacology (Berl) 122 15 26 10.1007/BF02246437 1:CAS:528:DyaK2MXpvVChtLs%3D
53. CP Ward JR Harsh KM York KL Stewart JG McCoy 2004 Modafinil facilitates performance on a delayed nonmatching to position swim task in rats Pharmacol Biochem Behav 78 735 741 15301929 10.1016/j.pbb.2004.05.005 1:CAS:528: DC%2BD2cXmsVGgtLY%3D (Pubitemid 39037733)
54. MC Wolff JD Leander 2003 Comparison of the effects of antipsychotics on a delayed radial maze task in the rat Psychopharmacology (Berl) 168 410 416 10.1007/s00213-003-1449-3 1:CAS:528:DC%2BD3sXmtVWguro%3D (Pubitemid 36994024)