The delivered dose: Applying particokinetics to in vitro investigations of nanoparticle internalization by macrophages

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 259-266

  Ahmad Khanbeigi, Raha ^a   Kumar, Abhinav ^a   Sadouki, Fethi ^a   Lorenz, Chris ^a   Forbes, Ben ^a   Dailey, Lea Ann ^a,b   Collins, Helen ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Diffusion; J774A.1 macrophages; Particokinetics; Phagocytosis; Polystyrene nanoparticles; Sedimentation

Indexed keywords

CELL CULTURE MEDIA; CELL MONOLAYERS; CYTOCHALASIN D; DOSE CORRECTION; DRUG CARRIER; DRUG DELIVERY SYSTEM; EXPERIMENTAL CONDITIONS; EXPOSURE CONDITIONS; IN-SILICO; IN-VITRO; LOW DENSITY; MACROPHAGE-LIKE CELLS; PARTICLE CONTENT; PARTICLE MASS; PARTICLE SEDIMENTATION; PARTICLE UPTAKES; PARTICOKINETICS; PHAGOCYTOSIS; POLYSTYRENE BEADS; POLYSTYRENE NANOPARTICLES; SURFACE AREA;

ANTIGEN-ANTIBODY REACTIONS; BIOLOGICAL MATERIALS; CELL CULTURE; DIFFUSION; DOSIMETRY; DRUG DELIVERY; EXPERIMENTS; FLUORESCENCE SPECTROSCOPY; MACROPHAGES; MONOLAYERS; NANOPARTICLES; PARTICLE SIZE; POLYSTYRENES; SEDIMENTATION; SEDIMENTS;

DRUG DOSAGE;

NANOPARTICLE; POLYSTYRENE;

ANIMAL EXPERIMENT; ARTICLE; CELL INTERACTION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOSIMETRY; FLUORESCENCE SPECTROSCOPY; IN VITRO STUDY; INTERNALIZATION; MACROPHAGE; MOUSE; NONHUMAN; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; MACROPHAGES; MICE; MICROSPHERES; MODELS, BIOLOGICAL; NANOPARTICLES; PARTICLE SIZE; PHAGOCYTOSIS; POLYSTYRENES;

EID: 84865310538     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.019     Document Type: Article

References (41)

1. E. Novik, T.J. Maguire, P. Chao, K.C. Cheng, and M.L. Yarmush A microfluidic hepatic coculture platform for cell-based drug metabolism studies Biochem. Pharmacol. 79 2010 1036 1044
2. A.P. Li In vitro evaluation of human xenobiotic toxicity: scientific concepts and the novel integrated discrete multiple cell co-culture (IdMOC) technology ALTEX 25 2008 43 49
3. T.T. Goodman, C.P. Ng, and S.H. Pun 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers Bioconjug. Chem. 19 2008 1951 1959
4. B. Halliwell Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett. 540 2003 3 6
5. B. Zheng, L. Tan, X. Mo, W. Yu, Y. Wang, L.T. Kellogg, R.E. Welsch, P.T.C. So, and H. Yu Predicting in vivo anti-hepatic fibrotic drug efficacy based on in vitro high-content analysis PLoS One 6 2011 e26230
6. R.N. Grass, L.K. Limbach, E.K. Athanassiou, and W.J. Stark Exposure of aerosols and nanoparticle dispersions to in vitro cell cultures: a review on the dose relevance of size, mass, surface and concentration J. Aerosol Sci. 41 2010 1123 1142
7. L.K. Limbach, Y. Li, R.N. Grass, T.J. Brunner, M.A. Hintermann, M. Muller, D. Gunther, and W.J. Stark Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration and diffusion at low concentrations Environ. Sci. Technol. 39 2005 9370 9376
8. J.G. Teeguarden, P.M. Hinderliter, G. Orr, B.D. Thrall, and J.G. Pounds Particokinetics In vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments Toxicol. Sci. 95 2007 300 312
9. P.M. Hinderliter, K.R. Minard, G. Orr, W.B. Chrisler, B.D. Thrall, J.G. Pounds, and J.G. Teeguarden ISDD: a computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies Part. Fibre Toxicol. 7 2010 36 56
10. R.J. Hunter Foundations of Colloid Science 2001 Oxford University Press New York
11. M. Smoluchowski Drei Vorträge über Diffusion, Brownsche Molekularbewegung und Koagulation von Kolloidteilchen Phys. Z. 17 1916 557 599
12. M. Mason, and W. Weaver The settling of small particles in a fluid Phys. Rev. 23 1924 412 426
13. M.C. Sterling, J.S. Bonner, A.N. Ernest, C.A. Page, and R.L. Autenrieth Application of fractal flocculation and vertical transport model to aquatic sol-sediment systems Water Res. 39 2005 1818 1830
14. T.G. Iversen, T. Skotland, and K. Sandvig Endocytosis and intracellular transport of nanoparticles: present knowledge and need for future studies Nano Today 6 2011 176 185
15. A.G. Ayuyan, and F.S. Cohen Raft composition at physiological temperature and pH in the absence of detergents Biophys. J. 94 2008 2654 2666
16. S.M. Hussain, K.L. Hess, J.M. Gearhart, K.T. Geiss, and J.J. Schlager In vitro toxicity of nanoparticles in BRL 3A rat liver cells Toxicol. In Vitro 19 2005 975 983
17. D.W. Goddette, and C. Frieden Actin polymerization. The mechanism of action of cytochalasin D J. Biol. Chem. 261 1986 15974 15980
18. G. Maiorano, S. Sabella, B. Sorce, V. Brunetti, A.M. Malvindi, R. Cingolani, and P.P. Pompa Effects of Cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response ACS Nano 4 2010 7481 7491
19. P.H. Cooper, P. Mayer, and M. Baggiolini Stimulation of phagocytosis in bone marrow-derived macrophages by bacterial lipopolysaccharide: correlation with biochemical and functional parameters J. Immunol. 133 1984 913 922
20. Invitrogen DMEM certificate of analysis (product #: 1196044; lot: 989006) http://tools.invitrogen.com/Content/SFS/COAPDFs/2011/989006-11960.pdf [accessed 01 May 2012]
21. Invitrogen fetal bovine serum (catalogue # 10437028) product specification http://tools.invitrogen.com/content/sfs/brochures/B-12637-r1-EU- 0804-FBS.pdf [accessed on 01 May 2012]
22. Y. Tabata, and Y. Ikada Effect of size and surface charge of polymer microspheres on their phagocytosis by macrophages Biomaterials 9 1988 356 362
23. M. Koval, K. Preiter, C. Adles, P.D. Stahl, and T.H. Steinberg Size of IgG-opsonized particles determines macrophage response during internalization Exp. Cell Res. 242 1998 265 273
24. M. Al Kobiasi, B.Y. Chua, D. Tonkin, D.C. Jackson, and D.E. Mainwaring Control of size dispersity of chitosan biopolymer microparticles and nanoparticles to influence vaccine trafficking and cell uptake J. Biomed. Mater. Res A 2012 10.1002/jbm.a.34153 published online March 2012
25. R.W. Niven Delivery of biotherapeutics by inhalation aerosol Crit. Rev. Ther. Drug Carrier Syst. 12 1995 151 231
26. D.A. Edwards, J. Hanes, G. Caponetti, J. Hrkach, A. Ben-Jebria, M.L. Eskew, J. Mintezes, D. Deaver, N. Lotan, and R. Langer Large porous particles for pulmonary drug delivery Science 276 1997 1868 1871
27. S. Azarmi, W.H. Roa, and R. Löbenberg Targeted delivery of nanoparticles for the treatment of lung diseases Adv. Drug Deliv. Rev. 60 2008 863 875
28. M. Geiser, M. Casaulta, B. Kupferschmid, H. Schulz, M. Semmler-Behnke, and W. Kreyling The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles Am. J. Respir. Cell Mol. Biol. 38 2008 371 376
29. M. Geiser Update on macrophage clearance of inhaled micro- and nanoparticles J. Aerosol Med. Pulm. Drug Deliv. 23 2010 207 217
30. F. Alexis, E. Pridgen, L.K. Molnar, and O.C. Farokhzad Factors affecting the clearance and biodistribution of polymeric nanoparticles Mol. Pharm. 5 2008 505 515
31. A. Aderem, and D.M. Underhill Mechanisms of phagocytosis in macrophages Annu. Rev. Immunol. 17 1999 593 623
32. P. Camner, M. Lundborg, L. Låstbom, P. Gerde, N. Gross, and C. Jarstrand Experimental and calculated parameters on particle phagocytosis J. Appl. Physiol. 92 2002 2608 2616
33. L. Kong, and B.X. Ge MyD88-independent activation of novel actin-Cdc42/Rac pathway is required for Toll-like receptor stimulated phagocytosis Cell Res. 18 2008 745 755
34. V. Rabolli, L.C.J. Thomassen, F. Uwambayinema, J.A. Martens, and D. Lison The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation Toxicol. Lett. 206 2011 197 203
35. H. Kato, M. Suzuki, K. Fujita, M. Horie, S. Endoh, Y. Yoshida, H. Iwahashi, K. Takahashi, A. Nakamura, and S. Kinugasa Reliable size determination of nanoparticles using dynamic light scattering method for in vitro toxicology assessment Toxicol. In Vitro 23 2009 927 934
36. D. Yarar, C.M. Waterman-Storer, and S.L. Schmid A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis Mol. Biol. Cell 16 2005 964 975
37. H.T. McMahon, and E. Boucrot Molecular mechanism and physiological functions of clathrin-mediated endocytosis Nat. Rev. Mol. Cell Biol. 12 2011 517 533
38. S. Mayor, and R.E. Pagano Pathways of clathrin-independent endocytosis Nat. Rev. Mol. Cell Biol. 8 2007 603 611
39. S. Kumari, M.G. Swetha, and S. Mayor Endocytosis unplugged: multiple ways to enter the cell Cell Res. 20 2010 256 275
40. A.I. Ivanov Pharmacological inhibition of endocytic pathways: is it specific enough to be useful? Meth. Mol. Biol. 444 2008 15 33
41. J.J. Gu, Y.F. Yu, E.P. Li, S.H. Ng, P.H. Yap, X.Q. Zhou, T.H. Cheng, and A.Q. Liu Real-time Measurement of Cellular Refractive Index and Thickness Using Cell Culture Chip Twelfth International Conference of Miniaturized Systems for Chemistry and Life Sciences, San Diego, CA 2008