Classical swine fever virus NS5A regulates viral RNA replication through binding to NS5B and 3'UTR

Virology

Volumn 432, Issue 2, 2012, Pages 376-388

  Chen, Yan ^a   Xiao, Jun ^a   Xiao, Jing ^b   Sheng, Chun ^a   Wang, Jing ^a   Jia, Lin ^a   Zhi, Yimiao ^a   Li, Guangyuan ^a   Chen, Jun ^a   Xiao, Ming ^a  

^a SHANGHAI NORMAL UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Classical swine fever virus; NS5A; NS5A NS5B interaction; NS5B; Viral replication

Indexed keywords

AMINO ACID; NONSTRUCTURAL PROTEIN 5A; NONSTRUCTURAL PROTEIN 5B; VIRUS RNA;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PESTIVIRUS; PESTIVIRUS INFECTION; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM; RNA REPLICATION; VIRUS REPLICATION;

3' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CLASSICAL SWINE FEVER VIRUS; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, VIRAL; IMMUNOPRECIPITATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

BORNA DISEASE VIRUS; BOVINE VIRAL DIARRHEA VIRUS 1; CLASSICAL SWINE FEVER VIRUS; HEPATITIS C VIRUS;

EID: 84865292048     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2012.04.014     Document Type: Article

References (36)

1. Appel N., Herian U., Bartenschlager R. Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructuralprotein 5A. J. Virol. 2005, 79:896-909.
2. Becher P., Thiel H.J. Genus pestivirus (Flaviviridae). The Springer Index of Viruses 2002, 327-331. Springer-Verlag, Heidelberg, Germany. C.A. Tidona, G. Darai (Eds.).
3. Cuthbert J.A. Hepatitis C: progress and problems. Clin. Microbiol. Rev. 1994, 7:505-532.
4. Fletcher S.P., Jackson R.J. Pestivirus internal ribosome entry site (IRES) structure and function: elements in the 5' untranslated region important for IRES function. J. Virol. 2002, 76:5024-5033.
5. Gong Y., Trowbridge R., Macnaughton T.B., Westaway E.G., Shannon A.D., Gowans E.J. Characterization of RNA synthesis during a one-step growth curve and of the replication mechanism of bovine viral diarrhea virus. J. Gen. Virol. 1996, 77:2729-2736.
6. Gosert R., Egger D., Lohmann V., Bartenschlager R., Blum H.E., Bienz K., Moradpour D. Identification of the hepatitis C virus RNA replication complex in huh-7 cells harboring subgenomic replicons. J. Virol. 2003, 77:5487-5492.
7. Grassmann C.W., Isken O., Tautz N., Behrens S.E. Genetic analysis of the pestivirus nonstructural coding region: defects in the NS5A unit can be complemented in trans. J. Virol. 2001, 75:7791-7802.
8. He Y., Yan W., Coito C., Li Y., Gale M., Katze M.G. The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins. J. Gen. Virol. 2003, 84:535-543.
9. Heinz F.X., Collett M.S., Purcell R.H., Gould E.A., Howard C.R., Houghton M., Moormann R.J.M., Rice C.M., Thiel H.-J. Family Flaviviridae. Virus Taxonomy: Seventh Report of the International Committee on Taxonomy of Viruses 2000, 859-878. Academic Press, Inc., San Diego, Calif. C.M. Fauquet, M.H.V. van Regenmortel, D.H.L. Bishop, E.B. Carstens, M.K. Estes, S.M. Lemon, J. Maniloff, M.A. Mayo, D.J. McGeoch, C.R. Pringle, R.B. Wickner (Eds.).
10. Huang L., Hwang J., Sharma S.D., Hargittai M.R.S., Chen Y., Arnold J.J., Raney K.D., Cameron C.E. Hepatitis C virus non-structural protein 5A (NS5A) is a RNA-binding protein. J. Biol. Chem. 2005, 280:36417-36428.
11. Isken O., Grassmann C.W., Sarisky R.T., Kann M., Zhang S., Grosse F., Kao P.N., Behrens S.E. Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus. EMBO J. 2003, 22:5655-5665.
12. Isken O., Grassmann C.W., Yu H., Behrens S.E. Complex signals in the genomic 3' nontranslated region of bovine viral diarrhea virus coordinate translation and replication of the viral RNA. RNA 2004, 10:1637-1652.
13. Kalliampakou K.I., Kalamvoki M., Mavromara P. Hepatitis C virus (HCV) NS5A protein downregulates HCV IRES-dependent translation. J. Gen. Virol. 2005, 86:1015-1025.
14. Masaki T., Suzuki R., Murakami K., Aizaki H., Ishii K., Murayama A., Date T., Matsuura Y., Miyamura T., Wakita T., Suzuki T. Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles. J. Virol. 2008, 82:7964-7976.
15. Moennig V., Plagemann P.G.W. The pestiviruses. Adv. Virus Res. 1992, 41:53-98.
16. Pankraz A., Thiel H.J., Becher P. Essential and nonessential elements in the 3' nontranslated region of bovine viral diarrhea virus. J. Virol. 2005, 79:9119-9127.
17. Quezada E.M., Kane C.M. The hepatitis c virus NS5A stimulates NS5B during in vitro RNA synthesis in a template specific manner. Open Biochem. J. 2009, 39-48.
18. Reed K.E., Gorbalenya A.E., Rice C.M. The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases. J. Virol. 1998, 72:6199-6206.
19. Sheng C., Chen Y., Xiao J., Xiao J., Wang J., Li G., Chen J., Xiao M. Classical swine fever virus NS5A protein interacts with 3'-untranslated region and regulates viral RNA synthesis. Virus Res. 2012, 163:636-643.
20. Sheng C., Zhua Z., Yua J., Wan L., Wang Y., Chen J., Gu F., Xiao M. Characterization of NS3, NS5A and NS5B of classical swine fever virus through mutation and complementation analysis. Vet. Microbiol. 2010, 140:72-80.
21. Shirota Y., Luo H., Qin W., Kaneko S., Yamashita T., Kobayashi K., Murakami S. Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity. J. Biol. Chem. 2002, 277:11149-11155.
22. Steffen S., Thiel H.J., Behrens S.E. The RNA-dependent RNA polymerase of different members of the family Flaviviridae exhibits similar properties in vitro. J. Gen. Virol. 1999, 80:2583-2590.
23. Tellinghuisen T.L., Foss K.L., Treadaway J.C., Rice C.M. Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein. J. Virol. 2008, 82:1073-1083.
24. Tellinghuisen T.L., Gorbalenya Marcotrigiano J., Rice, C.M.A.E. The NS5A protein of hepatitis C virus is a zinc metalloprotein. J. Biol. Chem. 2004, 279:48576-48587.
25. Tellinghuisen T.L., Marcotrigiano J., Rice C.M. Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature 2005, 435:374-379.
26. Tellinghuisen T.L., Paulson M.S., Rice C.M. The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein. J. Virol. 2006, 80:7450-7458.
27. Wang Y., Xiao M., Chen Jun., Zhang W., Luo J., Bao K., Nie M., Chen J., Li Bo. Mutational analysis of the GDD sequence motif of classical swine fever virus RNA-dependent RNA polymerases. Virus Genes 2007, 34:63-65.
28. Wang Y., Zhu Z., Wang P., Yu J., Wan L., Chen J., Xiao M. Characterisation of interaction between NS3 and NS5B protein of classical swine fever virus by deletion of terminal sequences of NS5B. Virus Res. 2011, 156:98-106.
29. Wu S.C., Chang S.C., Wu H.Y., Liao P.J., Chang M.-F. Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway. J. Biol. Chem. 2008, 283:29396-29404.
30. Xiao M., Bai Y., Xu H., Geng X., Chen J., Wang Y., Chen J., Li B. Effect of NS3 and NS5B protein on classical swine fever virus IRES-mediated translation and its host cellular translation. J. Gen. Virol. 2008, 89:994-999.
31. Xiao M., Chen J., Li B. RNA-dependent RNA polymerase activity of classical swine fever virus NS5B protein expressed in natural host cells. Acta Virologica 2003, 47:17-26.
32. Xiao M., Gao J., Wang W., Wang Y., Chen J., Chen J., Li B. Specific interaction between the classical swine fever virus NS5B protein and the viral genome. Eur. J. Biochem. 2004, 271:3888-3896.
33. Xiao M., Li H., Wang Y., Wang X., Wang W., Peng J., Chen J., Li B. Characterization of the N-terminal domain of classical swine fever virus RNA-dependent RNA polymeras. J. Gen. Virol. 2006, 87:347-356.
34. Xiao M., Wang Y., Zhu Z., Yu J., Wan L., Chen J. Influence of NS5A protein of classical swine fever virus on CSFV internal ribosome entry site-dependent translation. J. Gen. Virol. 2009, 90:2923-2928.
35. Xiao M., Wang Y., Zhu Z., Zhao W., Ding C., Yu J., Chen J. Influence of the 5'-proximal elements of the 5'-untranslated region of classical swine fever virus on translation and replication. J. Gen. Virol. 2011, 92:1087-1096.
36. Zhu Z., Wang Y., Yu J., Wan L., Chen J., Xiao M. Classical swine fever virus NS3 is an IRES-binding protein. Virus Res. 2010, 153:106-112.