A new cocrystal and salts of itraconazole: Comparison of solid-state properties, stability and dissolution behavior

International Journal of Pharmaceutics

Volumn 436, Issue 1-2, 2012, Pages 403-409

  Shevchenko, Anna ^a,b   Bimbo, Luis M ^a   Miroshnyk, Inna ^a   Haarala, Jorma ^b   Jelínková, Kristýna ^a   Syrjänen, Kaisa ^b   Van Veen, Bert ^b   Kiesvaara, Juha ^b   Santos, Hélder A ^a   Yliruusi, Jouko ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Research and Development   (Finland)

Author keywords

Cocrystal; Dissolution; Hygroscopicity; Phase transition; Preformulation; Salt; Thermodynamic stability

Indexed keywords

DIHYDROCHLORIDE; HYDROCHLORIC SALT; ITRACONAZOLE; MALONIC ACID; SODIUM CHLORIDE; TRIHYDROCHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG FORMULATION; DRUG STRUCTURE; HUMIDITY; MOISTURE; PRIORITY JOURNAL; SOLID STATE; THERMODYNAMICS; THERMOGRAPHY; THERMOGRAVIMETRY; WETTABILITY; X RAY DIFFRACTION;

ANTIFUNGAL AGENTS; CHLORIDES; CRYSTALLIZATION; DRUG STABILITY; ITRACONAZOLE; MALONATES; POWDER DIFFRACTION; SALTS; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84865291348     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.06.045     Document Type: Article

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