Preparation and evaluation of itraconazole dihydrochloride for the solubility and dissolution rate enhancement

International Journal of Pharmaceutics

Volumn 367, Issue 1-2, 2009, Pages 109-114

  Tao, Tao ^a   Zhao, Yan ^a   Wu, Jinjin ^a   Zhou, Beiyi ^b  

^a Shanghai Institute of Pharmaceutical Industry   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Dissolution rate; Itraconazole; Itraconazole dihydrochloride; Nanocrystals; Solubility

Indexed keywords

ACETONE; BETA CYCLODEXTRIN; HYDROCHLORIC ACID; ITRACONAZOLE; NANOPARTICLE; SODIUM CHLORIDE;

ARTICLE; ASSAY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CAPSULE; DRUG FORMULATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ECONOMICS; ENVIRONMENT; FEASIBILITY STUDY; GAS; HUMAN; INFRARED SPECTROSCOPY; LIGHT SCATTERING; LIQUID; MORPHOLOGY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; X RAY DIFFRACTION;

ADJUVANTS, PHARMACEUTIC; ANTIFUNGAL AGENTS; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DRUG COMPOUNDING; DRUG STABILITY; ITRACONAZOLE; MICROSCOPY, ELECTRON, SCANNING; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 58249102205     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.09.034     Document Type: Article

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