The evaluation of neutrophil-lymphocyte ratio in Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 34, Issue 2, 2012, Pages 69-74

  Kuyumcu, Mehmet Emin ^a   Yesil, Yusuf ^a   Oztürk, Zeynel Abidin ^b   Kizilarslanoǧlu, Cemal ^a   Etgül, Sezgin ^a   Halil, Meltem ^a   Ulger, Zekeriya ^a   Cankurtaran, Mustafa ^a   Aroǧul, Servet ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

Alzheimer's disease; Biomarkers; Dementia; Inflammation; Inflammatory markers

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; CALCIUM; CREATININE; TRIACYLGLYCEROL;

AGED; ALZHEIMER DISEASE; ARTICLE; BODY MASS; COGNITION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; HYPERTENSION; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; NERVOUS SYSTEM INFLAMMATION; NEUTROPHIL; NEUTROPHIL LYMPHOCYTE RATIO; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; ROC CURVE;

EID: 84865281097     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000341583     Document Type: Article

References (38)

1. Broussard GJ, Mytar J, Li RC, Klapste in GJ: The role of inflammatory processes in Alzheimer's disease. Inflammopharmacology 2012;20:109-126.
2. Querfurth HW, LaFerla FM: Alzheimer's disease. N Engl J Med 2010;362:329-344.
3. Yesil Y, Kuyumcu ME, Cankurtaran M, Uz B, Kara A, Kilic MK, Halil M, Ulger Z, Yavuz BB, Haznedaroǧlu IC, Ariogul S: Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD). Arch Gerontol Geriatr 2011, E-pub ahead of print.
4. Kuyumcu ME, Yesil Y, Ozturk ZA, Halil M, Ulger Z, Yavuz BB, Cankurtaran M, C?nar E, Ar?oǧul S: Alzheimer's disease is associated with a low prevalence of hypertension. Dement Geriatr Cogn Disord 2012;33:6-10.
5. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM: Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 2007;3:186-191.
6. Khansari PS, Sperlagh B: Inflammation in neurological and psychiatric diseases. Inflammopharmacology 2012;20:103-107.
7. Lee KS, Chung JH, Choi TK, Suh SY, Oh BH, Hong CH: Peripheral cytokines and chemokines in Alzheimer's disease. Dement Geriatr Cogn Disord 2009;28:281-287.
8. Azab B, Jaglall N, Atallah JP, Lamet A, Raja- Surya V, Farah B, Lesser M, Widmann WD: Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis. Pancreatology 2011;11:445-452.
9. Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL: Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006;97: 993-996.
10. Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M: The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007;73: 215-220.
11. Cho H, Hur HW, Kim SW, Kim SH, Kim JH, Kim YT, Lee K: Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother 2009;58:15-23.
12. Gomez D, Farid S, Malik HZ, Young AL, Toogood GJ, Lodge JP, Prasad KR: Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 2008;32:1757-1762.
13. Folstein MF, Folstein SE, McHugh PR: 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
14. Stahelin HB, Monsch AU, Spiegel R: Early diagnosis of dementia via a two-step screening and diagnostic procedure. Int Psychogeriatr 1997;9(suppl 1):123-130.
15. Rabe-Jab?ońska J, Bieńkiewicz W: Anxiety disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association: diagnostic and statistical manual of mental disorders (DMS-IV - options book) (in Polish). Psychiatr Pol 1994;28:255-268.
16. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
17. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140: 566-572.
18. Casserly I, Topol E: Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet 2004;363:1139-1146.
19. Yu D, Corbett B, Yan Y, Zhang GX, Reinhart P, Cho SJ, Chin J: Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 2012, E-pub ahead of print.
20. Matsumoto Y, Yanase D, Noguchi-Shinohara M, Ono K, Yoshita M, Yamada M: Cerebrospinal fluid/serum IgG index is correlated with medial temporal lobe atrophy in Alzheimer's disease. Dement Geriatr Cogn Disord 2008;25:144-147.
21. Lue LF, Rydel R, Brigham EF, Yang LB, Hampel H, Murphy GM, Brachova L, Yan SD,Walker DG, Shen Y, Rogers J: Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 2001;35:72-79.
22. Richartz E, Batra A, Simon P, Wormstall H, Bartels M, Buchkremer G, Schott K: Diminished production of proinflammatory cytokines in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2005;19: 184-188.
23. Sun YX, Minthon L, Wallmark A, Warkentin S, Blennow K, Janciauskiene S: Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2003;16:136-144.
24. El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD: Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 2007;13:432-438.
25. Walker DG, Lue LF, Beach TG: Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia. Neurobiol Aging 2001;22:957-966.
26. Block ML, Zecca L, Hong JS: Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 2007;8: 57-69.
27. Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W: Astrocytes are important mediators of aβ-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death Dis 2011;2:e167.
28. Jana A, Pahan K: Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease. J Neurosci 2010;30:12676-12689.
29. Hashioka S, Klegeris A, Schwab C, McGeer PL: Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells. Neurobiol Aging 2009;30:1924-1935.
30. Simonian NA, Coyle JT: Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 1996;36:83-106.
31. Granic I, Dolga AM, Nijholt IM, van Dijk G, Eisel UL: Inflammation and NF-kappaB in Alzheimer's disease and diabetes. J Alzheimers Dis 2009;16:809-821.
32. Uthamalingam S, Patvardhan EA, Subramanian S, Ahmed W, Martin W, Daley M, Capodilupo R: Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol 2011;107:433-438.
33. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS: Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102: 653-657.
34. Kishi Y, Kopetz S, Chun YS, Palavecino M, Abdalla EK, Vauthey JN: Blood neutrophilto- lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol 2009;16:614-622.
35. Sato H, Tsubosa Y, Kawano T: Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer. World J Surg 2012;36:617-622.
36. Azab B, Zaher M, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, Gobunsuy R, Jadonath S, Baldari D, McCord D, Lafferty J: Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106:470-476.
37. Baldus S, Heeschen C, Meinertz T, Zeiher AM, Eiserich JP, Munzel T, Simoons ML, Hamm CW, Investigators C: Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 2003;108:1440-1445.
38. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ: Early inflammation and dementia: a 25-year follow-up of the Honolulu- Asia Aging Study. Ann Neurol 2002;52: 168-174.