Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis

Pancreatology

Volumn 11, Issue 4, 2011, Pages 445-452

  Azab, Basem ^a   Jaglall, Neil ^a   Atallah, Jean Paul ^a   Lamet, Ari ^a   Raja Surya, Venkat ^a   Farah, Bachir ^a   Lesser, Martin ^b   Widmann, Warren D ^a,c  

^a STATEN ISLAND UNIVERSITY HOSPITAL   (United States)

^b DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Acute pancreatitis; Neutrophil lymphocyte ratio; Scoring risk system; Severity

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CALCIUM; CREATININE; GLUCOSE;

ACUTE PANCREATITIS; ADULT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CALCIUM BLOOD LEVEL; CREATININE BLOOD LEVEL; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HUMAN; HUMAN CELL; INTENSIVE CARE UNIT; LENGTH OF STAY; LEUKOCYTE COUNT; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NEUTROPHIL; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; UREA NITROGEN BLOOD LEVEL;

EID: 80054869025     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000331494     Document Type: Article

References (37)

1. Neoptolemos JP, Raraty M, Finch M, Sutton R: Acute pancreatitis: the substantial human and financial costs. Gut 1998; 42: 886-891. (Pubitemid 28277235)
2. Vege SS YD, Chari ST: pancreatitis; in Talley NJ, Locke GR, Saito YA (eds): GI Epidemiology, ed 1. Malden, Blackwell Publishing, 2007, p 221.
3. Russo MW, Wei JT, Thiny MT, Gangarosa LM, Brown A, Ringel Y, Shaheen NJ, Sandler RS: Digestive and liver diseases statistics, 2004. Gastroenterology 2004; 126: 1448-1453. (Pubitemid 38552807)
4. Sandler RS, Everhart JE, Donowitz M, Adams E, Cronin K, Goodman C, Gemmen E, Shah S, Avdic A, Rubin R: The burden of selected digestive diseases in the United States. Gastroenterology 2002; 122: 1500-1511. (Pubitemid 34465190)
5. Steinberg WM: Predictors of severity of acute pancreatitis. Gastroenterol Clin North Am 1990; 19: 849-861.
6. Lankisch PG, Schirren CA, Kunze E: Undetected fatal acute pancreatitis: why is the disease so frequently overlooked? Am J Gastroenterol 1991; 86: 322-326.
7. Windsor JA: Search for prognostic markers for acute pancreatitis. Lancet 2000; 355: 1924-1925. (Pubitemid 30326090)
8. Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH: Acute pancreatitis: value of CT in establishing prognosis. Radiology 1990; 174: 331-336. (Pubitemid 20038583)
9. Chatzicostas C, Roussomoustakaki M, Vardas E, Romanos J, Kouroumalis EA: Balthazar computed tomography severity index is superior to Ranson criteria and APACHE II and III scoring systems in predicting acute pancreatitis outcome. J Clin Gastroenterol 2003; 36: 253-260. (Pubitemid 36232638)
10. Garcea G, Jackson B, Pattenden CJ, Sutton CD, Neal CP, Dennison AR, Berry DP: Early warning scores predict outcome in acute pancreatitis. J Gastrointest Surg 2006; 10: 1008-1015. (Pubitemid 44037482)
11. Blamey SL, Imrie CW, O'Neill J, Gilmour WH, Carter DC: Prognostic factors in acute pancreatitis. Gut 1984; 25: 1340-1346. (Pubitemid 15180519)
12. Corfield AP, Cooper MJ, Williamson RC, Mayer AD, McMahon MJ, Dickson AP, Shearer MG, Imrie CW: Prediction of severity in acute pancreatitis: prospective comparison of three prognostic indices. Lancet 1985; 2: 403-407. (Pubitemid 15231247)
13. Dominguez-Munoz JE, Carballo F, Garcia MJ, de Diego JM, Campos R, Yangüela J, de la Morena J: Evaluation of the clinical usefulness of APACHE II and SAPS systems in the initial prognostic classification of acute pancreatitis: a multicenter study. Pancreas 1993; 8: 682-686. (Pubitemid 23319156)
14. Ranson JH: Etiological and prognostic factors in human acute pancreatitis: a review. Am J Gastroenterol 1982; 77: 633-638. (Pubitemid 12061420)
15. Wilson C, Heath DI, Imrie CW: Prediction of outcome in acute pancreatitis: a comparative study of APACHE II, clinical assessment and multiple factor scoring systems. Br J Surg 1990; 77: 1260-1264.
16. Malfertheiner P, Dominguez-Munoz JE: Prognostic factors in acute pancreatitis. Int J Pancreatol 1993; 14: 1-8. (Pubitemid 23252128)
17. Triantopoulou C, Lytras D, Maniatis P, Chrysovergis D, Manes K, Siafas I, Papailiou J, Dervenis C: Computed tomography versus Acute Physiology and Chronic Health Evaluation II score in predicting severity of acute pancreatitis: a prospective, comparative study with statistical evaluation. Pancreas 2007; 35: 238-242. (Pubitemid 47482516)
18. Garcea G, Gouda M, Hebbes C, Ong SL, Neal CP, Dennison AR, Berry DP: Predictors of severity and survival in acute pancreatitis: validation of the efficacy of early warning scores. Pancreas 2008; 37:e54-e61.
19. Gravante G, Garcea G, Ong SL, Metcalfe MS, Berry DP, Lloyd DM, Dennison AR: Prediction of mortality in acute pancreatitis: a systematic review of the published evidence. Pancreatology 2009; 9: 601-614.
20. Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, Jeffrey RR, Buchan KG, El-Shafei H, Hillis GS: Preoperative neutrophil- lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J 2007; 154: 995-1002. (Pubitemid 47632493)
21. Gillum RF, Mussolino ME, Madans JH: Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol 2005; 15: 266-271. (Pubitemid 40386500)
22. Halazun KJ, Hardy MA, Rana AA, Woodland DC 4th, Luyten EJ, Mahadev S, Witkowski P, Siegel AB, Brown RS Jr, Emond JC: Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg 2009; 250: 141-151.
23. Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E: Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 2009; 137: 425-428.
24. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS: Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008; 102: 653-657.
25. Zahorec R: Ratio of neutrophil to lymphocyte counts - rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102: 5-14.
26. Goodman DA, Goodman CB, Monk JS: Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis. Am Surg 1995; 61: 257-259.
27. Subbe CP, Kruger M, Rutherford P, Gemmel L: Validation of a modified early warning score in medical admissions. QJM 2001; 94: 521-526. (Pubitemid 32998342)
28. Garrey W: Variation in white blood cell counts. Physiol Rev 1935; 15: 597-638.
29. Skubitz K: Neutrophilic leukocytes; in Greer J, Wintrobe MM (eds): Wintrobe's Clinical Hematology, ed 12. Philadelphia, Wolters Kluwer/Lippincott Williams & Wilkins Health, 2009, pp 170-193.
30. Wittel UA, Rau B, Gansauge F, Gansauge S, Nussler AK, Beger HG, Poch B: Influence of PMN leukocyte-mediated pancreatic damage on the systemic immune response in severe acute pancreatitis in rats. Dig Dis Sci 2004; 49: 1348-1357. (Pubitemid 39178110)
31. Pavlov P, Uchikov P, Murdzheva M, Tuleva S, Tsvetkova T: Main lymphocyte populations and their subpopulations in patients with acute pancreatitis studied in the course of disease (in Bulgarian). Khirurgiia (Sofiia) 2001; 57: 4-11.
32. Pezzilli R, Billi P, Beltrandi E, Casadei Maldini M, Mancini R: Impaired lymphocyte proliferation in human acute pancreatitis. Digestion 1997; 58: 431-436. (Pubitemid 27445610)
33. Pezzilli R, Billi P, Beltrandi E, Maldini M, Mancini R, Morselli Labate AM, Miglioli M: Circulating lymphocyte subsets in human acute pancreatitis. Pancreas 1995; 11: 95-100.
34. Pezzilli R, Maldini M, Morselli-Labate AM, Barakat B, Romboli E, Beltrandi E, Migliori M, Tomassetti P, Corinaldesi R: Early activation of peripheral lymphocytes in human acute pancreatitis. J Clin Gastroenterol 2003; 36: 360-363. (Pubitemid 36331621)
35. Takeyama Y, Takas K, Ueda T, Hori Y, Goshima M, Kuroda Y: Peripheral lymphocyte reduction in severe acute pancreatitis is caused by apoptotic cell death. J Gastrointest Surg 2000; 4: 379-387.
36. Bain BJ: Ethnic and sex differences in the total and differential white cell count and platelet count. J Clin Pathol 1996; 49: 664-666. (Pubitemid 26264395)
37. Lichtman MA: Cellular deformability during maturation of the myeloblast. Possible role in marrow egress. N Engl J Med 1970; 283: 943-948.