Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats

Asian Pacific Journal of Cancer Prevention

Volumn 7, Issue 4, 2006, Pages 599-603

  Sakano, Katsuhisa ^a   Takahashi, Mami ^a   Kitano, Mitsuaki ^b   Sugimura, Takashi ^a   Wakabayashi, Keiji ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KANEKA CORPORATION   (Japan)

Author keywords

Azoxymethane aberrant crypt foci coq 10 colon chemoprevention

Indexed keywords

AZOXYMETHANE; DRUG DERIVATIVE; UBIDECARENONE; UBIQUINONE; VITAMIN;

ANIMAL; ARTICLE; COLON; DRUG EFFECT; FISCHER 344 RAT; MALE; PATHOLOGY; PRECANCER; RAT;

ANIMALS; AZOXYMETHANE; COLON; MALE; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; UBIQUINONE; VITAMINS;

EID: 33947502835     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bird RP (1987). Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett, 37, 147-51.
2. Bjelakovic G, Nikolova D, Simonetti RG, et al. (2004). Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet, 364, 1219-28.
3. Bonakdar RA, Guarneri E (2005). Coenzyme Q10. Am Fam Physician, 72, 1065-70.
4. Borek C (2004). Dietary antioxidants and human cancer. Integr Cancer Ther, 3, 333-41.
5. Caderni G, Femia AP, Giannini A, et al. (2003). Identification of mucin-depleted foci in the unsectioned colon of azoxymethanetreated rats: correlation with carcinogenesis. Cancer Res, 63, 2388-92.
6. Caderni G, Giannini A, Lancioni L, et al. (1995). Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis. Br J Cancer, 71, 763-9.
7. Crane FL (2001). Biochemical functions of coenzyme Q10. J Am Coll Nutr, 20, 591-8.
8. Exon JH, South EH, Taruscio TG, et al. (2004). Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats. Nutr Cancer, 49, 72-80.
9. Folkers K, Morita M, McRee J Jr (1993). The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun, 193, 88-92.
10. Folkers K, Osterborg A, Nylander M, et al. (1997). Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem Biophys Res Commun, 234, 296-9.
11. Folkers K, Shizukuishi S, Takemura K (1982). Increase in levels of IgG in serum of patients treated with coenzyme Q10. Res Commun Chem Pathol Pharmacol, 38, 335-8.
12. Frei B, Kim MC, Ames BN (1990). Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A, 87, 4879-83.
13. Halliwell, B (1999). Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanisms and the effects of nutrition. Mutat Res, 443, 37-52.
14. Jemal A, Murray T, Samuels A, et al. (2003). Cancer statistics, 2003. CA Cancer J Clin, 53, 5-26.
15. Jenab M, Chen J, Thompson LU (2001). Sialomucin production in aberrant crypt foci relates to degree of dysplasia and rate of cell proliferation. Cancer Lett, 165, 19-25.
16. Kawamori T, Tanaka T, Hara A, et al. (1995). Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Cancer Res, 55, 1277-82.
17. Khanzode SS, Muddeshwar MG, Khanzode SD, et al. (2004). Antioxidant enzymes and lipid peroxidation in different stages of breast cancer. Free Radic Res, 38, 81-5.
18. Lenaz G, Cavazzoni M, Genova ML, et al. (1998). Oxidative stress, antioxidant defences and aging. Biofactors, 8, 195-204.
19. Lenaz G, Fato R, Castelluccio C, et al. (1993). The function of coenzyme Q in mitochondria. Clin Invest, 71, S66-70.
20. Lockwood K, Moesgaard S, Yamamoto T, et al. (1995). Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun, 212, 172-7.
21. Mayne ST (2003). Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J Nutr, 133 suppl, S933-40.
22. McLellan EA, Bird RP (1988). Aberrant crypts: potential preneoplastic lesions in the murine colon. Cancer Res, 48, 6187-92.
23. Mori H, Hata K, Yamada Y, et al. (2005). Significance and role of early-lesions in experimental colorectal carcinogenesis. Chem Biol Interact, 155, 1-9.
24. Ochiai M, Watanabe M, Nakanishi M, et al. (2005). Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats.Cancer Lett, 220, 67-74.
25. Omenn GS, Goodman GE, Thornquist MD, et al. (1996). Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med, 334, 1150-5.
26. Overvad K, Diamant B, Holm L, et al. (1999). Coenzyme Q10 in health and disease. Eur J Clin Nutr, 53, 764-70.
27. Paulsen JE, Loberg EM, Olstorn HB, et al. (2005) Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat. Cancer Res, 65, 121-9.
28. Pretlow TP, Barrow BJ, Ashton WS, et al. (1991). Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res, 51, 1564-7.
29. Raju J, Swamy MV, Cooma I, et al. (2005). Low doses of betacarotene and lutein inhibit AOM-induced rat colonic ACF formation but high doses augment ACF incidence. Int J Cancer, 113, 798-802.
30. Schwartz JL (1996). The dual roles of nutrients as antioxidants and prooxidants: their effects on tumor cell growth. J Nutr, 126, 1221S-7S.
31. Stanner SA, Hughes J, Kelly CN, et al. (2004). A review of the epidemiological evidence for the 'antioxidant hypothesis'. Public Health Nutr, 7, 407-22.
32. Suzuki H, Yamamoto J, Iwata Y, et al. (1986). Effects of immunostimulation with OK432, coenzyme Q10, or levamisole on dimethylhydrazine-induced colonic carcinogenesis in rats. Jpn J Surg, 16, 152-5.
33. Terry P, Giovannucci E, Michels KB, et al. (2001). Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst, 93, 525-33.
34. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med, 330, 1029-35.
35. Tran MT, Mitchell TM, Kennedy DT, et al. (2001). Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy, 21, 797-806.
36. Uchida K, Kado S, Onoue M, et al. (1997). Relationship between the nature of mucus and crypt multiplicity in aberrant crypt foci in the rat colon. Jpn J Cancer Res, 88, 807-14.
37. Yamada Y, Yoshimi N, Hirose Y, et al. (2000). Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res, 60, 3323-7.