In vitro characterization and in vivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles

International Journal of Pharmaceutics

Volumn 396, Issue 1-2, 2010, Pages 194-203

  Dhana lekshmi, U M ^a   Poovi, G ^a   Kishore, Narra ^a   Reddy, P Neelakanta ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Anti diabetic; Nanoparticles; PMMA; Repaglinide

Indexed keywords

NANOPARTICLE; POLY(METHYL METHACRYLATE); REPAGLINIDE; SOLVENT; ANTIDIABETIC AGENT; CARBAMIC ACID DERIVATIVE; DRUG CARRIER; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DIFFUSION; DRUG FORMULATION; DRUG RELEASE; EVAPORATION; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; TOXICITY TESTING; ANIMAL; CHEMICAL MODEL; CHEMISTRY; DELAYED RELEASE FORMULATION; KINETICS; METHODOLOGY; NANOTECHNOLOGY; PHARMACEUTICS; SOLUBILITY; WISTAR RAT; X RAY DIFFRACTION;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CARBAMATES; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; HYPOGLYCEMIC AGENTS; KINETICS; MALE; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; PIPERIDINES; POLYMETHYL METHACRYLATE; RATS; RATS, WISTAR; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; THERMOGRAVIMETRY; X-RAY DIFFRACTION;

EID: 77955058134     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.06.023     Document Type: Article

References (42)

1. Ajit P.R., Sanamesh A.P., Anagha A.B., Shivaraj B.H., Tejraj M.A. Preparation and evaluation of cellulose acetate butyrate and poly (ethylene oxide) blend microspheres for gastro retentive floating delivery of repaglinide. J. Appl. Polym. Sci. 2007, 105:2764-2771.
2. Akashi M., Furuya K., Iwata M., Onishi H., Machida Y., Shirotake S. Trial for transdermal administration of sulphonylureas. Yakugaku Zassi 1997, 12:1022-1027.
3. Avinash B., Steven J.S., Karen I. Controlling the in- vitro release profiles for a system of haloperidol-loaded PLGA nanoparticles. Int. J. Pharm. 2007, 87-92.
4. Bala I., Hariharan S., Kumar M.N. PLGA nanoparticles in drug delivery the state of art. Crit. Rev. Ther. Drug Carrier Syst. 2004, 21:387-482.
5. Chaiwat N., Qinmin P., Garry L.R., Suda K. Synthesis of poly (methyl methacrylate) nanoparticles initiated by 2,20-azoisobutyronitrile via differential micro emulsion polymerization. Macromol. Rapid Commun. 2007, 28:1029-1033.
6. Chorny M., Fishbein I., Danenberg H.D., Golomb G. Liphophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J. Control. Release 2002, 83:389-400.
7. Costa P., Lobo J.M.S. Modelling and comparison of dissolution profiles. Euro. J. Pharm. Sci. 2001, 13:123-133.
8. Culy C.R., Jarvis B. Repaglinide: a review of its therapeutic use in type II diabetes mellitus. Drugs 2001, 61:1625-1660.
9. Davis S.N., Granner D.K. Insulin oral hypoglycemic agents and the pharmacology of the endocrine pancreas. Goodman and Gillman. The pharmacological basis of therapeutics 2001, 1704-1705. McGraw-Hill Medical Publishing Division, USA. J.G. Hardman, L.E. Limbrid (Eds.).
10. Donaldson K., Li X.Y., Mac N.W. Ultrafine (nanometer) particle mediated lung injury. J. Aerosol Sci. 1998, 29:553-560.
11. Dongming P., Huang K., Liu Y., Lin S. Preparation of novel polymeric microspheres for controlled release of finasteride. Int. J. Pharm. 2007, 342:82-86.
12. Douglas S.J., Davis S.S., Illum L. Nanoparticles in drug delivery. CRC Crit. Rev. Ther. Drug Carrier Syst. 1987, 3:233-261.
13. Duane, Birnbaum, Jacqueline, Peppas L.B. Optimization of preparation techniques for poly (lactic acid-co-glycolic acid) nanoparticles. J. Nanoparticle Res. 2000, 2:173-181.
14. Fassihi R.A., Ritschel W.A. Multiple layer, direct compression controlled release system: invitro and invivo evaluation. J. Pharm Sci. 1993, 82:750-754.
15. Finsy R., Dejaeger N., Sneyers R., Gelade E. Particle sizing by photon correlation spectroscopy. Part. Part. Syst. Char. 1992, 9:125-137.
16. Garcia M.F., Maria J.A., Dolores T. Design and characterization of a new drug nano carrier made from solid lipid mixtures. J. Colloid Interface Sci. 2005, 285:590-598.
17. Gelperina S.E., Khalansky A., Smirnova Z.S., Bobruskin A.I., Severin S.E. Toxicological studies of doxorubicin bound to polysorbate 80-coated poly (butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma. Toxicol. Lett. 2002, 126:131-141.
18. Govender T., Stolnik S., Martin C.G., Illum L., Stanley S.D. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J. Control. Release 1999, 57:171-185.
19. Grell W., Hurnaus R., Griss G. Repaglinide and related hypoglycemic benzoic acid derivatives. J. Med. Chem. 1998, 41:5219-5246.
20. Guyot M., Fawaz F. Nifedipine loaded polymeric microspheres: preparation and physical characterization. Int. J. Pharm. 1998, 175:61-74.
21. Hamid A.Merchant, Harris M.Shoaib, Jaweria Tazeen, Rabia Yousuf Once daily formulation and in vitro evaluation of cefopodoxime using hydroxy propyl methyl cellulose - a technical note. AAPS PharmSciTech. 2006, article. 78.
22. Hillye J.F., Abrecht R.M. Gastro intestinal per sorption & tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 2001, 90:1927-1936.
23. Hodges G.M., Carr E.A., Hazzard R.A., Roilly O., Carr K.E A commentary on morphological and quantitative aspects of micro particle translocation across the gastro intestinal mucosa. J. Drug Targeting 1995, 3:57-60.
24. Hoet M., Chen Z., Xing G., Yuan H., Chen C., Zhao F., Zhang C., Zhao Y. Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles. Toxicol. Lett. 2007, 175:102-110.
25. Jalehvarshosaz Use of hydrophilic natural gums in formulation of sustained release matrix tablets of Tramadol hydrochloride. AAPS PharmSciTech. 2006, 7:E1-E7.
26. Lam C.W., James J.T., Mc Cluskey R., Hunter R.L. Pulmonary toxicity of single-wall carbon nanotubes in mice, 7 and 90 days after intratracheal instillation. Toxicol. Sci. 2004, 77:126-134.
27. 2, propylene oxide and maleic anhydride. Polymer 2006, 47:8453-8461.
28. Majid Kazemian A., Paramanik D., Varma S., Gosavi S.W., Kulkarni S.K. Formation of gold nanoparticles in polymethylmethacrylate by UV irradiation. J. Phys. D: Appl. Phys. 2007, 40:3771-3779.
29. Nagappa A.N. Novel strategies for the therapeutic management of type II diabetes. Health Adm. 2008, 1-2:58-68.
30. Neelam Seedhar, Mamta Kanojia Co-solvent solubilisation of some poorly soluble anti diabetic drugs. Pharm. Dev. Technol. 2009, 14:185-192.
31. Niwa T., Takeuchi H., Hino N., Kunou Y. Preparation of biodegradable nanospheres of water soluble and insoluble drugs with dl-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. J. Control. Release 1993, 25:89-98.
32. Oberdorster E., Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005, 113:823-839.
33. Patrick, Donnell, James, Mc Ginity Preparation of microspheres by the solvent evaporation technique. Adv. Drug Deliv. Rev. 1997, 28:25-42.
34. Piao F., Yokoyama K., Ma N., Yamauchi T. Sub acute toxic effects of zinc on various tissues and organs of rats. Toxicol. Lett. 2003, 145:28-35.
35. Piao F.W., Zhu W. Effect of lead on thyroid function and morphology in pregnant rats. C. J. Ind. Hyg. Occp. Dis. 1991, 9:210-215.
36. Reddy K.R., Mutalik S., Reddy S. Once daily sustained release matrix tablets of nicorandil:formulation and invitro evaluation. AAPS PharmSciTech. 2003, 4:61.
37. Sood A., Pachangnula R. Drug release evaluation of dilitizem CR prepartions. Int. J. Pharm. 1998, 175:95-107.
38. Soppimath K.S., Kulkarni A.R., Aminabhavi T.M. Development of hollow microspheres as floating controlled-release systems for cardiovascular drugs: Preparation and release characteristics. Drug Dev. Ind. Pharm. 2001, 27:507.
39. Sunil K.J., Awasthi A.M., Jain N.K., Agarwal G.P. Calcium silicate based microspheres of repaglinide for gastro retentive floating drug delivery: preparation and in vitro characterization. J. Control. Release 2005, 107:300-309.
40. Sunil K.J., Agarwal G.P., Jain N.K. Porous carrier based floating granular delivery system of repaglinide. Drug Dev. Ind. Pharm. 2007, 33:381-391.
41. Wiesner M.R., Lowry G.V., Alvarez P., Dionysiou D., Biswas P. Assessing the risks of manufactured nanomaterials. ES&T 2006, 40:4336-4345.
42. Zhao Y.L., Meng H., Chen Z., Zhao F., Chai Z.F. Dependence of nanotoxicity on nanoscale characteristics and strategies for reducing and eliminating nanotoxicity. Nanotoxicology 2007, 265-280. American Scientific Publishers, California. Y.L. Zhao, H.S. Nalwa (Eds.).