Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of β-O-linked& beta;-N-acetylglucosaminidase

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28882-28897

  Macauley, Matthew S ^a   Chan, Jefferson ^a   Zandberg, Wesley F ^a   He, Yuan ^b   Whitworth, Garrett E ^a   Stubbs, Keith A ^c   Yuzwa, Scott A ^a   Bennet, Andrew J ^a   Varki, Ajit ^d   Davies, Gideon J ^b   Vocadlo, David J ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE POCKET; BIOSYNTHETIC PATHWAY; ENZYMATIC ACTIVITIES; HUMAN GUTS; METABOLIC PATHWAYS; MOLECULAR BASIS; N-ACETYLGLUCOSAMINE; N-ACETYLGLUCOSAMINIDASE; NUCLEOCYTOPLASMIC PROTEINS; O-LINKED; SALVAGE PATHWAY; STRUCTURAL STUDIES; THREONINE RESIDUES; TIME FRAME;

AMINO ACIDS; ENZYME ACTIVITY; MACHINERY; PROTEINS; SUBSTRATES; SUGARS;

METABOLISM;

AMINOSUGAR; BETA O LINKED BETA N ACETYLGLUCOSAMINIDASE; BETA O LINKED N GLYCOLYLGLUCOSAMINE; HEXOSAMINE; N ACETYL BETA GLUCOSAMINIDASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ARTICLE; BINDING SITE; CARBOHYDRATE ANALYSIS; CARBOHYDRATE METABOLISM; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; GLYCOSYLATION; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN PROCESSING;

ACETYLGLUCOSAMINIDASE; AMINO SUGARS; BACTERIA; BACTERIAL PROTEINS; CELL LINE; HUMANS; INTESTINES; SYMBIOSIS; URIDINE DIPHOSPHATE SUGARS;

EID: 84865216714     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.363721     Document Type: Article

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