Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships

Journal of the American Chemical Society

Volumn 131, Issue 37, 2009, Pages 13415-13422

  Greig, Ian R ^a,b   Macauley, Matthew S ^a   Williams, Ian H ^b   Vocadlo, David J ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b University of Bath Claverton Down   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDO GROUPS; CATALYTIC NUCLEOPHILES; EFFICIENT CATALYSTS; ENERGY RELATIONSHIPS; GLYCOSIDE HYDROLASES; LEAVING GROUPS; LINEAR FREE ENERGY RELATIONSHIPS; N-ACETYLGLUCOSAMINE; NUCLEOPHILIC STRENGTH; O-LINKED; OXOCARBENIUM; POST-TRANSLATIONAL MODIFICATIONS; RATE DETERMINING STEP; SMALL MOLECULES; SUBSTRATE STRUCTURE; THREONINE RESIDUES; TRANSITION STATE; TRANSITION STATE STRUCTURE;

AMINO ACIDS; CATALYSIS; ENZYMES; FREE ENERGY; GLUCOSE; PLANTS (BOTANY); SUGAR (SUCROSE);

SUBSTRATES;

ACETAMIDE; ACETYLGLUCOSAMINIDASE; GLYCOSIDASE; N ACETYLGLUCOSAMINE; NUCLEOPHILE;

ARTICLE; CATALYSIS; CATALYST; CROSS LINKING; ENERGY; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; FREE ENERGY RELATIONSHIP; GLYCOSIDATION; HYDROLYSIS; KINETICS; MOLECULAR PROBE; PHASE TRANSITION; REGULATORY MECHANISM; STEADY STATE; STEREOCHEMISTRY;

ACETYLGLUCOSAMINE; BETA-N-ACETYLHEXOSAMINIDASES; BIOCATALYSIS; GLYCOSIDES; HUMANS; HYDROLYSIS; ISOTOPES; KINETICS; LINEAR MODELS; SOLVENTS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 70349388222     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja904506u     Document Type: Article

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