Crystallographic Evidence for Substrate-assisted Catalysis in a Bacterial β-Hexosaminidase

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10330-10337

  Mark, Brian L ^a   Vocadlo, David J ^b   Knapp, Spencer ^c   Triggs Raine, Barbara L ^d   Withers, Stephen G ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c RUTGERS UNIVERSITY   (United States)

^d UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYSIS; CRYSTAL STRUCTURE; ENZYMES; X RAYS;

DIFFERENCE FOURIER ANALYSIS;

CRYSTALLOGRAPHY;

ASPARTIC ACID; BETA N ACETYLHEXOSAMINIDASE; GLYCOSIDASE; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; TYROSINE; HYBRID PROTEIN; THIAZOLE DERIVATIVE; TRYPTOPHAN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME DEFICIENCY; FOURIER ANALYSIS; GANGLIOSIDOSIS; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES PLICATUS; TAY SACHS DISEASE; X RAY CRYSTALLOGRAPHY; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRON; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; INFRARED SPECTROSCOPY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES PLICATUS;

ACETYLGLUCOSAMINE; ASPARTIC ACID; BETA-N-ACETYLHEXOSAMINIDASE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; ESCHERICHIA COLI; GANGLIOSIDOSES; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STREPTOMYCES; THIAZOLES; TRYPTOPHAN;

EID: 0035971079     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011067200     Document Type: Article

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